Severe form of LSDV. (A) Diseased calf showed, extreme dyspnea, nasal, ocular discharge, and respiratory manifestations. (B) Nodules present on the muzzle, as well as within the nasal and buccal mucosa. (C) Edema in legs and brisket and infected calf unable to stand. (D, E) The cutaneous lesion coalesced and large area of skin is sloughed creating deep ulcers.