Effect of different concentrations of ethanolic extract of Acacia modesta on carrageenan induced arthritis at different days, body weight, gross microscopic evaluation of rat paw and histopathology of rat paw where in case of 1; CFA induced arthritis and body weight, A showing carrageenan induced arthritis at different days and B showing treatment group where E-OM with 750mg/kg dose showed an increase in body weight at 28 day as compared with arthritic group. In case of 2; gross microscopic evaluation of rat paw. A showing bone erosion B is showing pannus formation C is showing vascular degenerative changes in case of 3; histological appearance of pannus formation, bone erosion and vascular degenerated changes (A-F). All histopathological parameters i.e. bone erosion, pannus formation and vascular degenerative changes were also reduced in arthritic rats as compared to Piroxicam. Gross microscopic rat paw evaluation at end of CFA model depicts severe edema in arthritic rats, less pannus formation and bone erosion in rats treated with E-AM. ***, **, * showing P≤0.05, P≤ 0.01, P≤ 0.001.