A histopathological slices  in  rat immunized with mixed Ag. at 28 day post immunization. (A) Liver showed perivascular and periductiolar MNCs infiltration with nuclear pyknosis and  hyper eosinophilic of hepatocyte cytoplasm. (B) Liver showed mild periductal MNCs infiltration with obvious ductal dilation. (C) Spleen showed periarteriolar lymphoid hyperplasia. (D) Spleen showed great lymphoid  hyperplasia with red pulp congestion.