Histopathological examination of rat kidney tissues by hematoxylin and eosin: a. control rats and b. CSO-administrated rat administrated rats are showing normal histological structure of renal glomeruli (RG) and real tubules (RT). c. DOX-treated rats showed mild focal interstitial inflammatory cells infiltration , diffuse moderate tubular epithelial linings degeneration, necrosis d. DOX-treated rat showing degeneration (arrow), necrosis, few apoptosis (dashed arrow) and desquamation (short arrow) of the renal tubular linings with cast formation (thin arrow)in the tubular lumens. e. CSO/DOX-treated rat mild to moderate degree of necrobiotic changes of the renal tubular epithelium with cast formation in lumen of scattered tubules (arrow) (H&E, X100)