A histopathological slices  in rat  immunized with Con-A at 28 day post immunization. (A) Liver showed perivenular  MNCs infiltration with ductal dilation. (B) Liver showed slight portal MNCs infiltration with ductal dilation. (C) Spleen showed reactive lymphoid hyperplasia with slight splenic vessels congestion. (D) Spleen showed lymphoid hyperplasia with vascular fibromuscular hypertrophy.