(H&E X20), A: showing CG brain, B:  brain of TG showing demyelination (star), chromatolysis of neuron, neuronal edema (yellow arrow) and perivascular edema. C: brain of DAG showing demyelination of brain (star) and perivascular edema (blue arrow), D: brain of BG showing decreased lesion severity, chromatolysis of neuron (red arrow) and congested blood vessels (blue arrow).