The P2Y3 antagonist NF45 has an effect on the mean kindling score of PTZ-kindling animals. (A) Seizure stage for each group. (B) Days of stimulation for each group at various phases. Group I, No treatment; Group II, infused with artificial cerebrospinal fluid; Group III, administered with NF 45; Group IV, administered with PTZ; Group V, administered with PTZ+30nm NF45; Group VI, administered with PTZ+60nm NF45; Group VII, administered with PTZ+90nM NF45; Group VIII, α-β- methylene-ATP+90nM NF45+PTZ.