AutoDock Vina was used to obtain the berberine molecular docking solution against the p-glycoprotein target berberine (A) in the ligand binding domain of (B) Ligand interaction diagram of the berberine docking pose (dark green conventional hydrogen bond; light green carbon hydrogen bond; dark pink-pi-pi stacked interaction; light pink pi-alkyl interaction; yellow pi-sulfur interaction); (C) berberine in the active sites defined by the hydrophobic surface and surrounding residues which are labelled and represented as thin grey lines). For clarity, hydrogen atoms are not displayed. (D) illustrates the dynamic character of interactions.