ALAN induced BC: MLT synthesis take place in pineal gland at night, however; ALAN reduced its production which results in abnormal epigenetic changes including DNA methylation and Histone acetylation. The promoter region is unmethylated and acetylated in normal tissue of TSG while it is methylated and deacetylated in cancer tissues. As a result, TSG become inactive and oncogenes become active leading to BC induction.