Effect of OR on the contents of CRH, ACTH and CORT (A), the pathological changes in hippocampal tissues (magnification: 200×) (B), and the expression levels of proteins (C).

CRH, corticotropin-releasing hormone; ACTH, adrenocorticotrophic hormone; CORT, Corticosterone; BDNF, Brain-derived Neurotrophic Factor; TrkB, Trosine kinase B; CREB, Cyclic adenosine monophosphatec response element binding protein; GR, Glucocorticoid Receptor; MR, Mineralocorticoid Receptor. ##p<0.01, compared with control group; **p<0.01, compared with CUMS group.