SASA patterns of A, PIK3CA (E545K); B, PIK3CA (Q546K); C, PIK3CA (H1047R); D, PTEN (R130G); E, PTEN (R130Q); F, PTEN (R173C) and G, AKT1 (E17K) showing that variants continuously fluctuate between soluble and non-soluble states leading to change their normal functions.