In NCM460 cells, GRh2 accelerates miR-30a-5p; Enhancive miR-30a-5p strengthens GRh2’s repression of inflammation and NF-κB pathway, and elevation of cell advancement. A, The relative miR-30a-5p in cells introduced with GRh2 at a concentration of 0, 10, 20, and 50 μM. B, TNF-α, IL-1β and IL-6 in cells introduced with 50 μM GRh2 and miR-30a-5p/NC mimic/inhibitor. A-B, RT-qPCR detection. C, ELISA detection the concentrations of TNF-α, IL-1β and IL-6 in cell culture medium. D, WB detection of the ratio of NF-κB p-p65 to NF-κB p65 protein. E, CCK-8 method detection of the cell viability. F, Flow cytometry detection of apoptosis. A-F, in NCM460 cells. C-F, behind GRh2 introduction and transfection. # P < 0.05, vs. the blank control in the DSS; *P < 0.05, vs. the NC mimic/inhibitor in the DSS; ^ P < 0.05, vs. the NC-mimic in the miR-30a-5p mimic; & P < 0.05, vs. the NC-inhibitor in the miR-30a-5p inhibitor.