Immunohistochemistry section of liver tissue from tetrodotoxin treated group (A) (0.5 µg/kg b.w), (B) (1µg/kg b.w) of male albino rats. (A) moderate immune positive cells for IL1 antibody (arrow) mainly around portal regain and central vein (B) moderate immune positive cells for IL1 antibody (arrow) mainly around portal regain and liver parenchyma. (C) (0.5 µg/kg b.w), (D) (1 µg/kg b.w) (C) scattered immune positive cells for TNFα antibody (arrow) in hepatocyte. (D) weak reactive immune positive cells for TNFα antibody (arrow) in hepatocyte of portal area. (DAB- chromogen, X40).