Pedigree and clinical manifestations. A, Pedigree of a consanguineous Pakistani family segregating autosomal dominant form of metaphyseal chondrodysplasia Schmid type. Double lines are indicative of consanguineous union. Clear symbols represent unaffected individuals while filled symbols represent affected individuals. The diagonal line through a symbol is indicative of a deceased family member. B, affected individual IV-13, V-17, IV-1, V-10, V-13, V-12, IV-6 from enrolled family showing disproportionate short stature with bowed legs.