A, B, C, D shows the liver control group 3 (Cancer alone without treatment) at 5th week of intraperitoneal injection of Polyvinyl pyrrolidone K-30. Hepatic cell degeneration associated with nuclear pyknosis (orange arrow) and cancer cell aggregation (ACs) around the portal area, accompanied by the infiltration of inflammatory cell and congestion (CV: central vein). (A. X 4, B. X10, C.X20, D. X40) (H and E).