Effects of GBH (25, 50, 75 and 100 mg/kg) administration on anxiety associated behaviors in male rats. (A) Total amount time spent in the center (TCA); (B) Number of returns into center area of the arena in the open-field behavior apparatus (NRC); and (C) Number of total squares (NTS) in the open field test. Results are expressed as mean ± SEM. * p<0.05, ** p<0.01, *** p<0.001.