Photomicrographs of a skin biopsy of generalized demodicosis infected dog showing (a) vacuolar degeneration of the epidermal prickle cells (black arrow) and severe dermatitis (red arrow). (b) Demodex mite in the follicle (red arrows). (c) periglandular inflammatory cells infiltration (red arrow) (H & E, X 200 (a & c ), X 400 (b).