Effect of the P2Y3 antagonist NF45 on learning and memory of PTZ-kindling animals, as assessed on Morris water maze. (A) PTZ impaired learning of rats and NF45 mitigated this damage in PTZ-kindling animals. (B, C) In a dose-dependent manner, NF45 raised the TSTQ and number of crossings in the platform area of PTZ-kindling animals on day 5. For details of groups, see Figure 2.