Assessment of wound healing in circular wounds with a 5 cm diameter in various experimental groups of rabbits. treated with (A) Tramadol on 7th day after burn. The diameter was 4.1cm (B) Remifentanil group, had an average diameter of 4.3 cm. (C) Lidocaine group, the average burn diameter was 3.3 cm (D) Remifentanil with epinephrine average burn diameter was 3.1 cm (E) Remifentanil with gel. The average diameter of the burned skin was 3.1 cm.