Experimental design of all methodological steps of the study. (A) Sample description of experimental groups and exposure to NaCl (0.9%) or AlCl3; (B) after the intrahippocampal injection, rats were submitted to the behavioral tests assessment through Open Field test (OFT), Elevated Plus Maze (EPM), Forced Swimming Test (FST), Y-maze and Morris Water Maze (MWM) test; (C) The animals were euthanized and the hippocampus was taken; (D) Thereafter, oxidative stress markers (lipid peroxidation (LPO), nitric oxide (NO) levels, and superoxide dismutase (SOD) activities) and (E) histology of CA3 area of the hippocampus were evaluated.