Effect of pioglitazone on the growth factors of ESC-bearing mice. a.Vascular endothelial growth factor (VEGF), and b. Insulin-like growth factor 1 (IGF1), and c. Epidermal growth factor (EGF). Data are expressed as mean ± SD, one-way ANOVA followed by post hoc test Bonferroni test for ten mice in each group. * Significant from the untreated control group, @ Significant from the cisplatin group, $ Significant from the Pio (LD) group, # Significant from the Pio (HD) group, & Significant from the Cis+ Pio (LD) group, p<0.05.