A schematic diagram representing intervention of Alantolactone with EGFR-mediated YAP signaling pathway and stemness properties. In the absence of EGFR ligand (EGF), LATS1/2 is phosphorylated (active). Upon activation, LATS1/2 induces YAP phosphorylation which ultimately results in cytoplasmic retention or degradation of YAP. Upon ligation with growth factor, EGFR become activated leading to MOB1 tyrosine phosphorylation and LATS1/2 dephosphorylation (inactive). Inactivation of LATS1/2 results in translocation of YAP into nucleus where it interacts with TEAD transcriptional factor and induces the expression of various genes associated with stemness properties of cell.