Atul Sharma, Aruna Chandra Singh, Gautam Bacher, Sunil Bhand

...he consequences of multi drug resistance and potential threat to human health and the environment. With the increasing incidences of antimicrobial contamination, especially in food, dairy products, agriculture and environment, their regular monitoring is on prime interest. Aptamers are synthetic short sequences of single stranded (ss) oligonucleotides (ss-RNA or DNA), which are developed by an in-vitro selection process known as “Systematic Evolution of ...
Junaid Akhtar1,2, Sidrah Saleem1, Naveed Shahzad3, Abdul Waheed1, Iqra Jameel1, Farhan Rasheed4 and Shah Jahan5,*
...ent option against multi-drug resistance GNR infections. However, the emergence of carbapenemases particularly metallo β-lactamases (MBLs) in bacteria have severely mitigated the efficiency of carbapenems. MBLs producing gram-negative bacteria have been reported from various hospital settings, worldwide. However, data is lacking in Pakistan regarding their frequency particularly among GNRs. Therefore, the present study aimed at determining the frequency o...
Sumreen Hayat1,6, Muhammad Hussnain Siddique2, Bilal Aslam1, Habibullah Nadeem2, Asma Ashraf3, Muhammad Saqalein1, Mohsin Khurshid4, Naveed Shahzad5 and Saima Muzammil1,*
.... The studyrevealed multidrug resistance phenotypes among K. pneumoniae isolates with higher prevalence of ESBL producing Klebsiella pneumoniae among the children with urinary tract infections. Based on our findings, it is recommended that the ESBL production should be routinely monitored especially among the K. pneumoniae strains for the effective management and control of such MDR pathogens.
...
Sher Bahadar Khan1,2,*, Zou Geng1, Cheng Yu-ting1, Asad Sultan3, Mumtaz Ali4,5, Irshad Ahmad6 and Rui Zhou1
...valent. Besides multiple drug resistance, they share many traits with the human pathogenic isolates based on virulence gene contents that may pose a potential threat to public health.

...
Shafqat Husnain Khan1, Shah Jahan2, Irshad Ahmad3,4, Sadeeq ur Rahman5,* and Tayyab ur Rehman4,*
...es.
...

Abdul Razzaq1*, Muhammad Islam2, Zahra Islam3, Zahida Fatima1, Munib Hussain4 and Farmanullah5,6 

... most part of the world, drug resistance against anthelmintic is now very common. In this context, various alternative control programs including herbal use against these worms is also an important option. To explore the problem, three available synthetic anthelmintic (Oxfendazole alone, oxfendazole-Levamisole combination and Ivermectin) were administered to natural major nematodes (Haemonchus, Trichuris, Strongyloides and Trichostrongylus) infected sheep and ...
Bo Gao1,2, Fengmei Yang3, Wei Chen2, Xiaojia Song4, Xiaobo Liu5 and Dongmin Li1*
...xpression level of Multi-drug resistance gene (MDR1) in common tumor malignancies, and evaluate the prognostic value of MDR1 expression in common malignancies. mRNA relative expression levels of MDR1 were detected byreal-time quantitative polymerase chain reaction (RT-qPCR) in tumor, adjacent, and non-cancerous tissues. The tumor markers were detected with COBAS 6000. The prognostic value of relative MDR1 expression level in malignant tumors was investigated b...

Olotu Titilayo Mabel*, Adeosun Idowu Jesulayomi, Kaka Mary Oluwatosin and Oladipo Elijah Kolawole 

Maryam Yousaf1, Naveed Shahzad2, Zeeshan Mutahir1 and Moazzam Ali1*
...ys have been linked with drug resistance in various cancers. However, the role of Rab21, an endocytic Rab GTPase, in the emergence of drug resistance is not known. Therefore, we aimed to investigate the role of Rab21 in MRP-1, drug efflux pump, mediated resistance in prostate cancer cells. Drug sensitive (PC-3/Wt) and epirubicin resistant (PC-3/Res) prostate cancer cell lines were used in this study. Our data revealed that P...

Tahseen Ullah* and Noor ul Amin

In Vitro Antibacterial Activity of Medicinal Plant Extracts
...y or antibiotic for multidrug resistance pathogenic plants and human bacterias. 

...
Sher Bahadar Khan1, Mumtaz Ali Khan2,*, Hameed Ullah Khan3, Sher Ali Khan4, Shah Fahad5, Faheem Ahmad Khan6, Irshad Ahmad7, Nighat Nawaz8, Sidra Bibi9 and Muhammad Muneeb10
...e found to have multiple drug resistance. As for as antibiotic resistant genes are concerned, the highest ARG was blaTEM (93%) followed by tetA (82%), sul2 (75%), blaSHV (72%), tetC (71%), strA/strB (50%), sul1 (49%), blaCMY2 and aadA (44%) while the least resistant gene was aadb (9%) followed by sul3 (21%) and aac(3)IV (37%). About 92% isolates were found to have multiple
Ayesha Talib1,2, Khanzadi Nazneen Manzoor1, Wajahat Ali1, Maria Saeed1, Muhammad Asif Gondal1, Malik Badshah3 and Abid Ali Khan1*
Yifan Ni1, Jian Liu1, Fen Wu1, Jianfeng Cai1, Jinzhi Zhang1*, Jianqing Hua2 and Jiping Fu2
Saima Yaqub1, Tahir Yaqub1*, Muhammad Zubair Shabbir2, Asif Nadeem3Aziz-Ul-Rahman1, Muhammad Furqan Shahid1, Zarfishan Tahir4 and Nadia Mukhtar4
Amjad Ali, Kafeel Ahmad*and Shaista Rahat
...9) isolates showed multi drug resistance. The MAR index of 34.22% (n=64) isolates was higher than 0.2. Phenotypic ESBL production was observed in 21.39% (n=40) isolates. Prevalence of blaOXA-10, blaCTX-M, blaTEM and blaSHV was 36.89% (n=69), 20.85% (n=39), 5.34% (n=10) and 3.2% (n=6) respectively. PER-1 gene was not detected. Resistance to antibiotics is increasing in P. aeruginosa which is a matter of concern and needs proper management. Non-selective ...
Asma Chaudhary1, Qurat-ul-Ain Ahmad1, Afia Muhammad Akram1, Sadia Roshan2 and Javed Iqbal Qazi3*
...fish. The emerging multi-drug resistance and related side effects of conventional therapies have caused researchers to explore alternate strategies, such as probiotics employment for disease control in aquaculture.
...
Basharat Ahmed1, Muhammad Hamza Azhar2, Farah R. Shakoori1 and Abdul Rauf Shakoori1,3,*
... ciprofloxacin. Multiple drug resistance was observed in this study ranging from three to eight drugs. 36 % were resistant to three or more antibiotics at 25µg/ml, 34 % were resistant to three or more antibiotics at 50µg/ml, 18 % were resistant to three or more antibiotics at 100µg/ml and 8 % were resistant to three or more antibiotics at 300µg/ml. The most common pattern of antibiotic resistance was Carbenicillin+ampicillin+co-trimoxaz...
Amreen Zahra1, Mushtaq A. Saleem1*, Hasnain Javed2, Muhammad Azmat Ullah Khan3, Muhammad Naveed1 and Abdul Rauf Shakoori4
...sites harboring dominant drug resistance mutations. 3D structure validation demonstrated 87.3% in Gag and 92.5% in Pol in the most favored regions. Dolutegravir, a protease inhibitor, was used for molecular docking to reveal the drug resistance sites among the isolates under investigation. However, strikingly the binding energies resulted were -7.9 kcal/mol for Pol and -5.7 kcal/mol in Gag that predicted that SNPs in the Pol...
Bingjie Zhou1, Hitesh Bhagavanbhai Mangukiya1, Siva Bharath Merugu1, Fakhar-un-Nisa Yunus1, Yuchen Fan1, Zhenghua Wu1,* and Dawei Li1,2,*
...e cancer progression and drug resistance, the abnormal expression of AGR2 is also involved in diseases like asthma and inflammatory bowel disease. Studies on the role of AGR2 in tumor micro-environment can help potential therapeutic development. Here, we report the generation of a fluorescent functional AGR2 fusion protein as a powerful visual tracking tool to trace the external function of AGR2. This bioactive and auto-fluorescent his-tag recombinant AGR2-DsR...

Pakistan Journal of Zoology

December

Vol. 53, Iss. 6, Pages 2001-2521

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