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The-Effective-Role-of-Phitofert-®-Supplement-in-Male-Reproductive-Hormones-and-Epididymal-Sperm-Quality-in-Carbon-Tetrachloride-CCL4-Treated-Rats

The-Effective-Role-of-Phitofert-®-Supplement-in-Male-Reproductive-Hormones-and-Epididymal-Sperm-Quality-in-Carbon-Tetrachloride-CCL4-Treated-Rats

Wassan Mhammed Husain1*, Zainab Sattar Ali2 

1College of health & medical technology, Uruk University, Iraq; 2College of Pharmacy-University of Al-Muthana, Iraq.

*Correspondence | Wassan Mhammed Husain, Uruk University, Iraq; Email: Wassan.mh.husain@uruk.edu.iq 

ABSTRACT

The goal of this study was to see if Phitofert ® might help improve sperm function in carbon tetrachloride (CCL4) -treated and healthy adult rats. Twenty-four adult rats were randomly divided into four groups and given the following treatments for 28 days: G1: as a control, the animals were oral administration with DW. G2: healthy rats were given 0.035 mg/kg BW of Phitofert ® every day by gavage. G3: twice a week, they were given 500 mg/kg B.W. of CCL4 mixed with an equivalent volume of olive oil (o.5 ml/kg B.W.). G4: were treated twice a week with 500 mg/kg BW of CCL4 mixed with an equivalent amount of olive oil (o.5 ml/kg BW) and gavaged with (0.035 mg/kg BW) of Phitofert ® daily. In the tenth and twenty-eighth of the experiment, blood samples were taken by heart puncture for serum collection. In comparison to all other groups, the current results reveal a significant (p≤0. 05) decrease in testosterone, somatic testicular index, and sperm quality in the G3 group, nevertheless, there was a significant (P<0.05) increase in LH, FSH, sperm abnormalities percent, and dead sperm percent in the G3 group. The capacity of Phitofert ® to restore all passive effects of CCL4 and increase epididymal sperm quality was demonstrated in G4 groups.

Keywords | CCl4, Phitofert ®, Epididymal sperm, Testicular somatic index, Macca rote 

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Advances in Animal and Veterinary Sciences

February

Vol. 11, Iss. 2, Pages 189-354

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