Studies on the Identification of Variants in Ribosomal RNA Genes in Maternal Diabetic Families: A Combined Approach Involving Nucleotide Sequence Analysis and Bioinformatics
Studies on the Identification of Variants in Ribosomal RNA Genes in Maternal Diabetic Families: A Combined Approach Involving Nucleotide Sequence Analysis and Bioinformatics
Sajid ul Ghafoor1*, Aziz-ud-Din1*, Khushi Muhammad1, Inamullah1 and Abid ul Ghafoor2
Fig. 1.
Pedigree of diabetic family from Swat Khyber Pakhtunkhwa Pakistan.
Fig. 2.
MT-RNR2 gene alteration status at genomic position m.1811. Samples A1, B1, B3, B4, B7, B8, and B10 of a Diabetic Family from Swat Khyber Pakhtunkhwa Pakistan. A>G Variation was highlighted with a vertical arrow at “1811”.
Fig. 3.
Reference and altered 16S rRNA at position 141A>G. A>G variation was highlighted with a vertical arrow at “141”.
Fig. 4.
RNA Fold structure of 16S rRNA molecule and impact of a single 141A>G variation.
(a) Reference structure; (b) Altered structure. The red encircled area specifies the structural variation.
Fig. 5.
Zoomed superimposed 3D structures of whole 16S rRNA specifying position 141A>G.
(a) Superimposed chains reference yellow and altered blue. (b) Zoomed 141A>G with distance i.e., 86.004Å.
August 2025
Pakistan J. Zool., Vol. 57, Iss. 4, pp. 1503-2002
