SARS-CoV-2 Delta Variant Does Not Sustain Replication in Companion Dogs: Insights from an Experimental Infection Model
SARS-CoV-2 Delta Variant Does Not Sustain Replication in Companion Dogs: Insights from an Experimental Infection Model
Lespek Kutumbetov1, Balzhan Myrzakhmetova1, Ainur Nurpeisova1, Zhandos Abay1*, Sandugash Sadikaliyeva1,2, Kamshat Shorayeva1, Kuanysh Jekebekov1, Yeraly Shayakhmetov1, Elina Kalimolda1, Alisher Omurtay1, Syrym Kopeyev1, Gulnur Nakhanova1, Bolat Yespembetov1, Asankadyr Zhunushov2, Hansang Yoo3, Sergazy Nurabayev1, Berik Khairullin4, Aslan Kerimbayev1, Markhabat Kassenov1, Kunsulu Zakarya1
Study design and timeline of the SARS-CoV-2 Delta strain challenge study in dogs.
Body weight and temperature changes in dogs post-infection with SARS-CoV-2. Data represent mean ± SEM (n=5 per group). CG: control group; EG: experimental group.
Lung histology on day 7 post-infection. (A) Atelectasis; (B) Alveolar emphysema. Hematoxylin and eosin (H and E) stain. Magnification ×40.
Chronic obstructive centrilobular emphysema. Thinning and lysis of alveolar septal elastic fibers; hyperelastosis of endplates (indicated by arrows). H and E stain. Magnification ×40.
Pulmonary vasculature showing congestion. H and E stain. Magnification ×40.
Lung histology on day 21 post-infection. (A) Dilated bronchus with epithelial proliferation; (B) Hemorrhagic inflammation. H and E stain. Magnification ×40.
Lung histology in a control dog. (A) Normal expanded alveolar spaces; (B) Cross-section of a bronchus without pathology. H and E stain. Magnification ×40.
