Histopathological Changes Affected by Oral Administration of Diclofenac Sodium in the Bone Marrow of Male Albino Rats (Rattus rattus)
Histopathological Changes Affected by Oral Administration of Diclofenac Sodium in the Bone Marrow of Male Albino Rats (Rattus rattus)
Wurood Hassan Hadi, Ali Hasan Abood*, Ameer Ali Shakir Imarah
ABSTRACT
Diclofenac is a remedy nonsteroidal anti-inflammatory drug (NSAID); that is used for treating the manifestations of rheumatoid arthritis and is being deliberate for forbidding of some types of skin cancer. It plugs releasing substances that cause inflammation and pain. It may also prevent the outgrowth of new blood vessels that tumors need to get bigger. Diclofenac is most potent, so a little amount of diclofenac is needed to relieve pain. Diclofenac is commonly used for arthritis-related joint pain. Twenty white rats were used, the group was divided into four subgroups, each containing five rats for thirty days of oral directing 50, 100 and150 mg/kg daily, with the control group receiving normal physiological saline, the second group given with 50 mg/kg daily of the cure, the third group given with 100 mg/kg daily of the cure, the fourth group was given 150 mg/kg daily of the cure. The rats were slaughtered after the groups received the treatment for one month. in addition to semithin sections for light microscopic examination, followed by statistical studies. This survy, the xeno-biotic is run on the lab-animals top of a period of 15 to 28 days, and the target mainly to pick out short-term toxic effects or injury that might manifest from refined exposure. Duration: Usually scop from 2 to 5 weeks, during the time blood or tissue specimens are taken up to an eye on any changes in physiology or chemical indicator. This allows for the detection of toxic consequence that may come into view only follow up repeated exposure over a short period. (Bemidinezhad, et al. 2023). The study showed that the rat bone marrow was affected adversely via the managing with Diclofenac at 50, 100 and150 mg/kg daily for 30 days in histologic structure and easy to perceive differences were observed after light microscopy was used to examine different sections of bone from control and treated animals. The Diclofenac-treated groups’ bones showed more active haemopoietic tissue (hypercellularity) relative to adipocytes (white spaces). Diclofenac can cause significant but long-term harm. so this attempt was to determine the effect of Diclofenac on many physiological criteria and several histological indicators in the bone marrow of male rats
Novelty Statement | This study reveals that long-term diclofenac sodium manifest may cause bone marrow hypocellularity, reducing hematopoietic cells and potentially leading to pancytopenia, anemia, and increased infection risk—a drug-induced effect not widely recognized before.
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