Genomic Study of Silent Heat: A Novel Mutation in HSD17β1 Gene Muting the Potential of Black Gold of Asia
Genomic Study of Silent Heat: A Novel Mutation in HSD17β1 Gene Muting the Potential of Black Gold of Asia
Basit Imtiaz1, Asif Nadeem2, Huma Mujahid1 and Maryam Javed1*
Base insertion (G) in Exon-2 of HSD17β1 gene in Nili-Ravi buffalo. A, Sequence alignment of Bubalus bubalis (XM_006055742.2) with Nili-Ravi buffalo of Pakistan indicated the insertion of ‘G’ base at position 3491. B, p.3491 indicated the shifting of amino acid sequence of subsequent chain.
Prediction of functional protein association network of HSD17β1 protein in Bubalus bubalis. A, HSD17B1 indicated a complex functional linkage with other members of estradiol 17 beta dehydrogenases. B, shows the details of abbreviations.
HSD17β1 protein. A, 3-D protein model prediction by fold recognition method; B, trans-membrane helix between 113 to 128 residues; C, secondary structure prediction by PSIPRED.
