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Effects of Tetrahydroxystilbene Glucoside on VEGF and MMP-9 Protein Expression in Kidney Tissues of Rats with Diabetic Nephropathy

Effects of Tetrahydroxystilbene Glucoside on VEGF and MMP-9 Protein Expression in Kidney Tissues of Rats with Diabetic Nephropathy

Xiaojing Liu and Zhongxin Li*

Department of Nephrology, Beijing Luhe Hospital, Capital Medical University, No. 82, Xinhua South Road, Tongzhou District, Beijing 101149, China

 
* Corresponding author: fyll30u@163.com

ABSTRACT

The purpose of this study was to investigate intervention effects of tetrahydroxystilbene glucoside (TSG) in diabetic nephropathy (DN) rats and analyze its action on vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP-) 9 protein expression in kidney tissues, in order to reveal the mechanism of TSG. After 12 weeks of administration, compared with those in the DN modeling group, 24 h urine protein, serum creatinine (Scr), blood urea nitrogen (BUN), blood uric acid (UA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) significantly reduced in rats treated with TSG (20 mg/kg) (P<0.05), blood total protein (TP) and albumin (ALB) significantly increased (P<0.05), VEGF expression significantly reduced (P<0.05) and MMP-9 expression significantly increased (P <0.05). The present study results showed that TSG could reduce proteinuria levels, slow down the progression of DN, and have a certain protective effect on the kidney in DN rats; and its mechanism of action might be related to down-regulated VEGF protein expression and up-regulated MMP-9 protein expression in kidney tissues.

 

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Pakistan Journal of Zoology

October

Vol. 54, Iss. 5, Pages 2003-2500

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