Effect of Rifampicin on the Adhesion Ability and Biofilm of Mycobacterium tuberculosis in diabetic patients Suffering from Tuberculosis
Effect of Rifampicin on the Adhesion Ability and Biofilm of Mycobacterium tuberculosis in diabetic patients Suffering from Tuberculosis
Xiaohu Fu1*, Guofu Zhao2 and Bin Luo3
ABSTRACT
The objective of this study was to explore the effect of Rifampicin on the Adhesion Ability and Biofilm of Mycobacterium tuberculosis (MT) in diabetic patients with tuberculosis complicated. Seventy patients with type II diabetes and tuberculosis who were admitted to Shangrao Municipal Hospital from June 2019 to June 2020 were randomly divided into a control group (CG, n=35) and an observation group (OG, n=35). The CG was treated with rifampicin capsules, and the OG was treated with rifampicin sterilized powder. The adhesion ability and biofilm formation of MT were analyzed by electron microscope. After eight months of the treatment, the total effective rate of the OG was much higher than that of the CG. Compared with the CG, the probability of gastrointestinal reaction and liver function damage in patients of the OG was significantly lower, and the difference was statistically significant (P<0.05). After the rifampicin intervention, the number of adherent colonies on the interface of the three implants decreased significantly (P<0.05). The biofilm is destroyed in varying degrees under 400 times field of vision. The use of rifampicin for injection in patients with diabetes and tuberculosis can improve the condition of tuberculosis, which has good safety and medical propaganda significance. MT adheres to the surface of implant and forms tuberculosis biofilm, which has certain selectivity and specificity. After the rifampicin intervention, the number of colonies attached to the interface of titanium alloy, CoCrMo, and polyethylene decreased significantly, and the biofilm formed on the surface of polyethylene is damaged with ladder style. It was concluded that the local application of anti-tuberculosis drugs has a great effect.
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