Effect of Nickel Oxide Nanoparticles on Antioxidant Enzyme System and Hematology of Tilapia
Effect of Nickel Oxide Nanoparticles on Antioxidant Enzyme System and Hematology of Tilapia
Shakeela Manzoor1, Sana Aziz2*, Sajid Abdullah1 and Muhammad Sarfraz Ali3
ABSTRACT
This study evaluated the effects of NiO-NPs on oxidative stress and hematological parameters in tilapia. Fish were exposed to different NiO-NPs concentrations (0.5, 1.0, and 1.5 mg/L) for 14 days. The experiment involved collecting blood samples and various organs such as the gills, liver, kidney, and muscles of fish to evaluate activity of superoxide dismutase (SOD) and catalase (CAT). The results of the study showed that SOD activity increased in the gills, liver, kidney, and muscles of fish at 0.5 mg/L and 1.0 mg/L of NiO-NPs concentration. However, SOD activity decreased after exposure to 1.5 mg/L NiO-NPs, compared to the control group. In gills and muscles, CAT activity significantly increased at 0.5 mg/L and 1.0 mg/L NiO-NPs concentrations, while its activity decreased at 1.5 mg/L NiO-NPs, but no significant (P<0.05) variation trend was observed in the liver and kidneys compared to the control group. Exposure to NiO-NPs also had an adverse effect on hematological parameters such as red blood cells (RBCs), white blood cells (WBCs), and hemoglobin (Hb) of fish. These findings suggest that NiO-NPs can negatively impact fish and aquatic ecosystems.
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