Dexmedetomidine Ameliorates Anxiety-Like Behaviors Induced by Sleep Deprivation in Mice
Dexmedetomidine Ameliorates Anxiety-Like Behaviors Induced by Sleep Deprivation in Mice
Hong Liu1, Li Zhang2, Yuan Xing Lu3 and Ling Tang4*
Schematic illustration of experimental design.
Sleep deprivation reduced the body weight of male mice. The body weight is measured every 24 h and expressed as an intervention starting on one day weight changes. The difference was significant (P<0.05) . * P <0.05 compared to normal control. The data represents the mean ± SEM. n = 8/group.
A, Horizontal movement traces in the OFT; B, The volcano figure in the OFT; C, entries in time (n = 8); D, time in center (%) (n = 8); E, total distance (n = 8). The results represent the mean ± standard error of the mean for each group. Values not sharing a common superscript letter differ significantly at p < 0.05. Those with the same letter do not differ significantly (p ≥ 0.05).
Horizontal movement traces in the EPM (A), the volcano figure in the EPM (B), time in open arms (%) (n = 8) (C), open arm entries (n = 8) (D), total arm entries (n = 8) (E). The results represent the mean ± standard error of the mean for each group. Values not sharing a common superscript letter differ significantly at p < 0.05; those with the same letter do not differ significantly (p ≥ 0.05).
DEX reverses SD-induced alterations in hippocampal GABA (A) and NE (B) levels of neurotransmitters. * p < 0.05, compared with control group; * p < 0.05, compared with SD group. Data are expressed as mean ± SEM (n = 8 per group).
