Association of Interleukins to Rheumatoid Arthritis
Association of Interleukins to Rheumatoid Arthritis
Summia Azam1, Sri Rahayu2, Atira Saba3, Afsana Huseynova Anvar4, Muhammad Irfan1*
A schematic diagram showing different receptors and interleukin families that take part in pathogenesis during rheumatoid arthritis. The interleukin receptors or interleukins that show positive relationship between SNPs/genes and phenotype of disease are shown. On the basis of functional properties, receptor chain similarities and sequence homology interleukins are given to each of the family. Moreover, overlap between such families can exist. In rheumatoid arthritis the Polymorphisms in genes that encodes for interleukins and interleukin receptors are involved. The binding of ligand starts phosphorylation of intracellular cascades and are intervened through different kinases including IRAK (interleukin 1 receptor associated kinase), MAPK (mitogen-activated protein kinase), JAK (Janus kinase), TNF (tumor necrosis factor receptor associated factor) and TRAF. These kinases result in transduction of signals by specific transcription factors [Mainly STAT (signal transducers and activators of transcription), NF-κB (nuclear factor kappa light chain enhancer of activated B cells)]. Several anti-inflammatory and pro inflammatory cytokine genes that are involved in Pathogenesis are stimulated by above mentioned transcription factors. (Modified from Magyari et al., 2014).
