Exposure of Pregnant Mice to Hexavalent Chromium Causes Fetal Defects
Exposure of Pregnant Mice to Hexavalent Chromium Causes Fetal Defects
Madeeha Arshad1, Naveed Ahmad2,*, Muhammad Khalid3, Asmatullah1, Mohammad Tahir2, Khadija Naveed1 and Asia Iqbal4
Madeeha Arshad1, Naveed Ahmad2,*, Muhammad Khalid3, Asmatullah1, Mohammad Tahir2, Khadija Naveed1 and Asia Iqbal4
ABSTRACT
The present study is aimed at determining the teratogenic effects of different doses of Cr VI, administered to pregnant mice. LD50 of Cr VI, was calculated as 88mg/kg of B.W in pregnant mice. Among 05 groups of pregnant females (10 females in each group), three were treated with 50%, 25% and 12.5% of the LD50 of Cr VI, respectively, with one control and one vehicle control group. Fetuses were recovered on 18th day of gestation and fixed for morphometric and morphological studies. Experimental groups showed variable degree of fetal abnormalities, along with reduction in body weights parallel to increase in dose concentration, as compared to control and vehicle control. Morphometric studies showed significant differences in nervous, integumentary and skeletal systems against control. Exencephaly, Omphalocoel, hygroma and limb abnormalities were recorded. It is shown that Cr VI causes teratogenic effects in mice embryos.
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August 2017
Vol. 49, Iss. 4, Pages 1151-1546
