The retention time of dopamine (DA) and dihydroxyphenyl acetic acid (DOPAC) in standard solution (A) and striatal brain region (B) of rats representing by HPLC chromatogram. Effect of prior administration of curcumin (100 mg/kg/day) for 15 days on neurotransmitter levels (C). DA (ng/g of brain tissue) and DOPAC (ng/g of brain tissue) levels were analyzed at the end of present study. Significant differences were obtained by one-way ANOVA following Tukey’s test. **p<0.01 versus controls and ++p<0.01 versus rotenone injected group (n=6).