Histopathological changes in the liver tissue of mice in each group. Comments: Mice were treated with vehicle for control or anti-tuberculosis drugs for 3, 5, 7, 10, and 15 days, and then liver samples were processed routinely and stained with H&E for morphologic evaluation (original magnification × 100). D: Control; H: isoniazid, R: rifampicin, Z: pyrazinamide, and HRZ: INH + RFP + PZA.