Effect of curcumin on muscular strength for all four paws was assessed by Kondziela test. Rotenone impaired the muscular strength of rats as observed by significantly decreased time to hold the inverted screen as compared to controls (**p<0.01). 15 days pre-treatment with curcumin attenuated the effects of rotenone on motor coordination as evident by significantly increased inverted screen score in Cur+Rot group as compared to rotenone (n=6) injected rats (++p<0.01). Significant differences were obtained by one-way ANOVA followed by Tukey’s test. Values are mean+SD (n=6).