A, changes in MDA levels in dogs with VL and healthy controls. There is a significant increase in CVL group (P<0.001) when compared with the control group. MDA: malondialdehyde, CVL: canine visceral leishmaniasis; B, changes in antioxidant defense in dogs with VL and healthy controls. In CVL group, there is a significant reduce in TAC (P<0.05) and GSH (P<0,01) levels when compared with the control group. TAC, total antioxidant capacity; GSH, glutathione; CVL, canine visceral leishmaniasis.