Figure 1: PPRV infection model: A) PPRV infection occurs through the respiratory tract, where antigen presenting cells (APC) (possibly dendritic cells (DC), macrophages and monocytes) are infected. Early infection results in IFN induction probably leading to APC migration to the draining lymph node. B) Once infected APC reach the draining lymphatic organ, where PPRV further replicates, causing cell death. PPRV blockade of IFN response and signaling helps the virus immunosuppress the host and spreading. C) PPRV is then disseminated systemically (probably through T cells) to distant lymphatic tissue where further replication and virus expansion can occur. D) Finally, PPRV infects epithelia, where more evident clinical signs of infection are detected (pneumonia and gastroenteritis) and high viral loads can be detected. It should be noted that virus shedding starts prior to severe clinical signs appear.