Open field activity was performed to monitor the ambulatory activity in rats. Rotenone affected the motor skills of the rats and significantly decreased (A) latency to move, (B) number of squares crossed confirming the loss of motor activity. Values are represented as mean+SD (n=6). Data was analyzed by Tukey’s test following one-way ANOVA. Mean values were significantly different than that for controls (**p<0.01, *p<0.05) and rotenone (n=6) injected rats (++p<0.01, +p<0.05).