Hıstological and electron micrographic structure of ovary of 1 mg/L TiO2 exposed group; a, degeneration at microvili structure and mitochondrial deterioration (star) at follicular epithelium cells; b, cytoplasmic vacuolization and unification (asterix) of cortical alveoli; c, mitochondrial deterioration (star); d, mitochondrial swelling (square) and loss of organization of cristae (arrow) at mitochondrium; e, cytoplasmic vacuolization (black arrow) at primary oocytes; f, loss of nucleolus organization at primary oocyte; g, severe cytoplasmic vacuolization and degeneration at cortical alveoli structure; h, Eosinophilic granules accumulation at cortical alveolus stage ZR, zona radiata; Mi, microvilli; Fe, follicular epitheium; T, teca cells; M, mitochondrium,;N, nucleus; No, nucleolus; Ca, cortical alveoli; Eg, eosinophilic granule. Magnification: e, f,g, x100; h x40.