The Sertoli cells proliferation was promoted via miR-122/PDK4/DUSP4 and miR-449a/FKBP1B pathways. A, Sertoli cells proliferation was analyzed by MTT assay after the cells were transfected with miR-122 mimics, miR-122 inhibitor and miR-shNC; B, Sertoli cells proliferation was analyzed by MTT assay after the cells were transfected with miR-449a mimics, miR-449a inhibitor and miR-shNC (**p<0.05, **p<0.01).