Pedigrees showing haplotypes of chromosome 7q microsatellite markers. The alleles forming the risk haplotype shaded black, and alleles not segregating with Pendred syndrome shown in white. The vertical lines shows recombination crosses at proximal and distal sides of linkage region. Squares: males; Circles: females; Filled symbols: affected individuals; Double line between individuals: consanguineous marriages and a diagonal line through the symbol: deceased person. Carriers of c.1667A>G share a common haplotype (black color) not observed in non-carrier members.