Comparison of geometric mean titer of treatment groups against FMD virus strains O, A and Asia 1 (a, b and c) and Pasteurella multocida (d). Study includes seven groups: A, control; B, 45 days prepartum group without vitamin E and selenium supplementation; C, 45 days prepartum group with vitamin E and selenium supplementation; D, 60 days prepartum group without vitamin E and selenium supplementation; E, 60 days prepartum group with vitamin E and selenium supplementation; 45 days prepartum group with vitamin E and selenium supplementation; F, 75 days prepartum group without vitamin E and selenium supplementation; G, 75 days prepartum group with vitamin E and selenium supplementation. At day 0 minimal number of antibodies was observed which increases suddenly and with the passage of time it starts dropping again. Highest antibody (p<0.05) titer was observed in group G at any time.