Abiodun D. Olabode
...rcated forty-sampled quadrats from both irrigated and non-irrigated farms. Information on socio-economic activities of the rice farmers, level of rice yield, agricultural practices for rice production and farm management techniques employed in the study area were observed. The study employed simple percentages to analyse the farmers’ responses; while regression model established significant relationships between rice yield and farm management methods ado...
Laila M. Fadda1, Nouf M. Al-Rasheed1, Iman H. Hasan1, Hanaa M. Ali2,3*, Nawal M. Al-Rasheed1,4, Musaed Al-Fayez5, Aly M. Ahmed5, Nada Almutlaq1, Nehal Qasem1 and Reem Khalaf1
...onse to APAP toxicity in rats. Serum aminotransferases (ALT and AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total protein, total bilirubin, hepatic glutathione (GSH), nitric oxide (NO), superoxide dismutase (SOD) and lipid peroxides (LP) levels were estimated. Moreover these biochemical parameters were confirmed by histopathological examination using hemotoxylin and eosin (H&E) and Mason trichrome stains (MTC). Immunohistochemical invest...
Asmaa Hamid1,* and Samia Kalsoom2
...;">Albino Sprague-Dawley rats (n=42) were randomly divided into seven groups, each of six rats. One group comprised of normal rats fed on basic purified diet AIN-76-A, three groups were alloxan induced diabetic rats which were fed basic purified diet AIN-76-A, Kabuli chickpea HFD and Bengal gram HFD and were monitored for random blood glucose and weight ...
Jixue Hou1,2, Xueling Chen3, Jing Wang4, Hongwei Zhang2, Yu Xi2, Jie Xia2, Xinyu Peng2,* and Xiangwei Wu2,5*
...e pigs, rabbits, and big rats. The mice with reproduction fast cycle, lower costing, and close to human genes, can be showed about some phenomenon quickly, also more easy to form model of atherosclerosis. Thus, a mouse model of vascular injury is vitally important for researching the pathophysiological mechanisms to restenosis after percutaneous transluminal coronary angioplasty (PTCA) as well as translational approaches. In this Experiment, we established a u...
Memoona Akber1, Muhammad Mushtaq1,*, Muhammad Sajid Nadeem1, Amjad Rashid Kayani1 and Noor-un-Nisa2
...ril 2012. A total of 100 rats (R. norvegicus = 65, Rattus rattus = 35) were trapped during 720 trap nights @ 0.13 captures per night and the trap success was 13.88%. Maximum captures of the Norway rats were recorded during summer (n = 33), followed by winter (n = 13), autumn (n = 12) and the least number was recorded during spring (n = 7). A non-significant difference between numbers of captured individuals of ...
Yi-qiang Ouyang1, Zhen-xin Liang1, Shi-wen Huang2, Ying Zhang3, Shao-shi Luo1, Jin-ning Liang1, Jia-fu Li1, Yu He4 and Song-chao Guo1,*
...o;s disease (AD) involve rats and mice, yet the tree shrew (Tupaia belangeri) is in many respects more similar to primates than rodents are. To demonstrate the feasibility and usefulness of using the tree shrew as an AD model, we examined how well the model recapitulates features of the disease. Injecting animals intraperitoneally with d-galactose to induce acute senility, and then injecting them with β amyloid fragment 1-42 and ibotenic acid into ...
Mustafa Cengiz1*, Jama Hussein Ali2, H. Mehtap Kutlu2, Djanan Vejselova2 and Adnan Ayhanci3
...alactosamine (D-GaIN) in rats. With this in mind, the rats were categorized into five groups. The study groups were given saline, 0.2 % dimethyl sulfoxide, D-GaIN, EA plus D-GaIN and D-GaIN plus EA, respectively. In the group given D-GaIN, the following transmission electron microscopic and light microscopic results were found: degenerative changes in the liver tissue, significant decreased in the number of activated Bcl-2, ...
A. Hamid1,*, M. Ilyas2 and S. Kalsoom3
...ced hypercholesterolemic rats. Insoluble dietary fiber (lignin and cellulose) was extracted from wheat and maize, while ß glucan was extracted from barley and sorghum. Male rats (n = 32), weighing 200-220 g were induced with hypercholesterolemia and were equally divided into 5 groups to study the effect of purified diet-AIN-93 G, wheat bran feed (WBF) , maize bran feed (MBF), sorghum ß glucan feed (SGF) and barle...
Mehmet Guvenc1,*, Ayşe Nilay Guvenc3, Ökkeş Yılmaz2 and Mehmet Tuzcu2
...veratrol on the liver of rats induced by fructose was investigated. Adult male Winstarrats were randomly divided into four groups; control, resveratrol, fructose, and resveratrol plus fructose. Resveratrol was administered 30 mg/kg intraperitoneally. Fructose (10% w/v) was administered with drinking water for 56 days every alternate day. Fructose administration increased the hepatic omega-6/omega-3 and 16:1 n7 / 16:0 ratios ...
Tahira Perveen1,*, Shaista Emad1, Saara Ahmad2, Zehra Batool1, Sarwat Yousuf1, Sheeza Sheikh1, Sara Qadeer1 and Saida Haider1
...nt drug, fluoxetine. The rats were divided into three groups as control, drug and oil which were respectively treated with water, fluoxetine (0.3 mg/kg) and fennel oil (0.5 ml/day). The treatment was continued for three weeks. Struggling time in forced swim test (FST), number of square crossed in open field test (OFT) and time spent in open arm in elevated plus maze (EPM) was monitored weekly. Repeated administration of fennel oil for 3 weeks showed significan...
Pan Hong, Ruonan Li, Yumeng Li, Hainan Lan* and Xin Zheng*
...one (GH) from humans and rats have been extensively reported. However, to date, there are no descriptions of the cell behaviour of porcine GH in domestic animals. Thus, freshly isolated porcine hepatocytes were used as a somatic cell model to study the internalization and subcellular localization of porcine growth hormone (pGH), and the results showed that pGH could be internalized into porcine hepatocytes in a time-dependent manner. The results also showed th...
Faiza Hassan1, Mubshara Saadia1,*, Muhammad Sher1, Mian Anjum Murtaza2, Muhammad Arshad3,Asam Riaz4 and Mahmood Ahmad Khan5
...Alloxan induced diabetic rats were post treated with plant extracts (150 mg/kg) and serum samples were collected from overnight fasted diabetic rats on day 15 to observe thepercent changes in blood glucose levels and lipid profile. Garlic extracts have shown the significant (p<0.001) hypoglycemic activity with no considerable effect on mean body weight of rats (ns, p>0.05) as compare...
Soraya Khosravian Dehordi*, Abdolnaser Mohebbi and Kahin Shahanipour
... oxidative status in the rats spleen exposed to the cadmium (Cd) metal. For this purpose, thirty male rats equally divided into six groups, group I received nano-Se (0.1mg/kg) alone as dose, group II selenite odium (0.1mg Se/kg) alone, group III Cd chloride (300mg/250cc), group IV Cd along with nano-Se, group V Cd along with selenite sodium and group VI (control) given (1 ml) saline. All doses was orally (gavage) given to ra...
Abd El-Nasser Ahmed Mohammed*
...nsplantation in mice and rats. Eighteen adult female rats were classified to three equal groups in addition to sex young females as donor of young ovaries. Similar classification was done using eighteen female mice and sex young females. The females of mice or rats were anesthetized for ovarian transplantation using (6.2 and 13.2 mg/kg BW) and (13.3 and 26.6 mg/kg BW) diazepam and xylazine...
Saara Ahmad1,*, Iftikhar Ahmed2, Saida Haider3, Zehra Batool3, Fatima Ahmed4, Saiqa Tabassum3,6, Syeda Madiha3, Tahira Perveen3 and Saad Bilal Ahmed5
...ent study was done on 75 rats divided randomly in 5 equal groups fed with rat chow, caged chicken meat, uncaged chicken meat, raw spinach and soybean for a period of six weeks. The levels of plasma cholesterol, progestril, estradiol, and androgens were estimated at the end of the experiment. The ovaries of the rats were collected, weighed and histopathologically evaluated for the development of cysts. It was seen that the ov...
Attia Anwar1, Sajida Malik2*, Zobia Usman1 and Sadia Chiragh3
...counts of Sprague-Dawley rats. For this purpose, twenty Sprague-Dawley rats were divided in two groups. Group A (n=10) was given distilled water and Group B (n=10) was supplemented berberine hydrochloride with dose of 75 mg/kg body weight/day. 24 weeks post-treatment, blood samples were collected by cardiac puncture from both groups and tested for Hb (%), WBC, RBC and platelet counts, SGPT, alkaline phosphatse, serum uric ac...
Promy Virk
... mg/kg) induced diabetic rats was assessed for a period of 7 weeks. Metformin was used as a standard drug. The results of Zetasizer and Transmission and Scanning Electron Microscopy images showed the presence of spherical to irregularly shaped green gold and silver (Au/Ag) nanopcomposite with an average size of 73.18 nm with polydispersity. A typical optical absorption peak at approximately 2.30 keV and 3.0 keV corresponded to the surface plasmon resonance pro...
Mohammad Umar Farooq* , Sarfraz Ahmad ** , Mohammad Islam and Imtiaz Ahmad Qamar ***
ASSESSING THE STATUS OF CARBON POOL IN TWO RANGELAND GRASSES ( ) IN POTHWAR, REGION, PAKISTAN
...Similarly, the one m quadrats were dig out up to the root level for each grass and separated the root portion and weighed, oven dried at 60 C for below ground phytomass carbon Mg C ha estimation. Carbon pool in above ground phytomass was 1.16 Mg C ha while below ground phytomass, 0.29 Mg C ha was recorded. The carbon sequestration in below ground and the aerial phytomass depends upon the management practices, climate and response of different species....
Ambreen Asghar, Tasleem Akhtar, Nadeem Sheikh*
...se, two groups of Wister rats were fed with diets carrying difference in percentage of fats. Protein profiling of treated groups indicated a marked increase in serum protein (related to iron metabolism and immune response) level compared to low fat-fed rats. Additionally, a decreased level of serum proteins was observed in the serum compared to control rats. Taken together, our findings co...
Syeda Madiha, Zehra Batool, Saiqa Tabassum, Laraib Liaquat, Sadia Sadir, Tahira Perveen and Saida Haider*
Jia Chen*, Yuanxi Deng and Hui Xu
...ive and negative sera of rats, the special allergen was identified with the Western Blot, showing that the 12kDa was the specific allergen. The protein of 12kDa was then analyzed by ion exchange and gel filtration chromatography, and the MALDI-TOF/TOF-MS search on the Internet. The results indicate that the protein was diamine- N-acetyltransferase.
...
Xiaojie Ding, Xiling Sun, Zuien Wang, Qiusheng Zheng, Xiaofei Yu, Wenjin Hao, Kejun Wang, Wenjuan Xu and Zhengping Dong*
...-kB signaling pathway in rats with diarrhea-predominant irritable bowel syndrome (IBS-D). The model was established by means of acetic acid enema plus restraint stress. The rat fecal moisture content, fecal trait score, and abdominal wall withdrawal reflex (AWR) score were used to determine whether the model was successful. The effects of Wumei Pill on the TLR4/9-NF-kB signaling pathway rats with IBS-D was observed by testin...
Muhammad Babar Khawar1, Muddasir Hassan Abbasi2*, Zillay Mariam1, Nadeem Sheikh1,2*
...ty of leachate in Wistar rats. Wistar rats of about 250g were selected and divided into three groups namely Control, Group 1 and Group 2. Group 1 was given 4ml/kg leachate while Group 2 received 4ml/kg of 1:10 diluted leachate intra-peritoneally. After 24 hours of the injection, animals were euthanized and blood was drawn for further studies. Data were analyzed using one way ANOVA. Serological analysis of both Group 1 and Gr...
Ashraf M. Mounir, A.N. El shahat* and A.M. Abdul Azeem
...gainst ISO-induced MI in rats were the two aims of this study. The total phenolic content and total flavonoids of frankincense has been significantly increased under the effect of gamma-rays in this work. Injection of isoprenaline hydrochloride (100 mg/ kg B.Wt./day) to rats resulted in cardiac oxidative stress, inflammation, hyper-lipidemia and increase cardiac marker enzymes. Treatment of rats
Muhammad Babar Khawar, Nadeem Sheikh*
Effect of paper industry leachate on various serological indices and serum proteins of wistar rats
...d the division of Wistar ratsof about 245±5g in three groups (n=5) viz, Control group (4ml/ kg normal saline), Group 1 (4ml/ kg leachate) and Group 2 (4ml/ kg 1:10 diluted leachate). All the animals received the treatment through intraperitoneal injection. After 24h of the injection, all the animals were sacrificed and blood was collected, sera were separated and processed for further analysis. Serological analysis revealed that leachate induction leads...
Tasleem Akhtar, Nadeem Sheikh*
Induction of acute phase in response to tacrolimus induced hepatotoxicity
...imental groups of wistar rats. Control group was provided with normal drinking water and dissections were done after 6, 12, 24 and 48 h of tacrolimus dose. Densitometric analysis revealed considerable elevated level of some positive acute phase proteins, specifically C-reactive protein, haptoglobin and ceruloplasmin. While albumin and transferrin levels were found to be low as compared to control animals. The results obtained in this study revealed that tacrol...
Muhammad Mohsin Ahsan1, Hafiz Muhammad Tahir2, Muhammad Khalid Mukhtar1
Effect of lunar cycle on active population density of scorpions, their potential prey and predators
...ds, centipedes, mice and rats) was noted in the presence or absence of moonlight, but they were
observed to be more active during the moonlight period than during moonless nights....
observed to be more active during the moonlight period than during moonless nights....
Muhammad Babar Khawar1, Muddasir Hassan Abbasi1, 2, Sana Fatima3, Khawaja Abdul Mujeeb2, Nadeem Sheikh1
Alterations in proteins and transaminases activity induced by thioacetamide in albino rats
...tration in albino
rats. Rats were randomly divided into three groups (n=3) namely control group, 12h group and 24h group. Each
experimental group (12h and 24h) was administered 300 mg/ kg TAA intraperitoneally (i.p) while control received
same volume of normal saline solution. Rats of 12h and 24h group were killed after 12 and 24h of TAA administration
respectiv...
rats. Rats were randomly divided into three groups (n=3) namely control group, 12h group and 24h group. Each
experimental group (12h and 24h) was administered 300 mg/ kg TAA intraperitoneally (i.p) while control received
same volume of normal saline solution. Rats of 12h and 24h group were killed after 12 and 24h of TAA administration
respectiv...
Atiq-ur-Rehman1,2,*, Abida Latif1,*, Rukhsana Anwar1, Nasir Abbas1, Sajid Nawaz2 and Hamid Turab Mirza3
...were administered to the rats and the samples of blood were taken at 0 h, 0.5 h, 1 h, 2 h and 3 h intervals. In vitro results showed that chloroform fraction at concentration of 100 µg/ml showed maximum α-amylase inhibition (53.11 ± 0.97% with IC50 value of 93.61 ± 4.44 µg/ml) followed by ethyl acetate, n-hexane and n-butanol fractions. The reference standard acarbose (100 µg/ml) showed α-amylase inhibition (6...
A.M. Abdul Azeem, A.N. El Shahat* and Ashraf M. Mounir
...r and hepato-toxicity in rats. From the results, it was obtained that gamma irradiation induced significant increase in the total phenolic content and antioxidant activity of pomegranate peels powder. Concurrent treatments of lead-injected rats with GPE induced significant reduction in serum activities of liver enzymes, level of hepatic and testicular lipid peroxidation and plasma levels of caspase 3 associated with signific...
Shaher Bano1, Sarah Ghafoor1,* and Nadia Naseem2
...ntly unknown.Twelve male rats were taken at week three and twelve at week seven and divided into control and experimental groups. Control rats were given normal saline while experimental rats were given T3 at a dose of 1mg/kg body weight. All the animals were sacrificed on 15th day. Weight of each rat was calculated at the time of T3 administration. Body weight of experimental a...
Zhen-li Li1,2, Hui-fang Zhou2,*, Bo-ru Zhou2, Bei Liu2, Xiao-fei Jiang2 and Jian-ya Xu2
...mifepristone-induced LPD rats. To explore the effect of BSZYF on the pituitary in mifepristone-induced LPD rats, SD female rats were administered mifepristone suspension via oral gavage, followed by pharmaceutical intervention. Then, the serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels were detected by ELISA, FSHβ and LHβ expression levels in the pitui...
Yang Liu1, Jing-xin Mao2, Xiao-dong Wei2, Man Yi2, Xiao-long Zhang2, Ke Zheng3, Xian-xin Chen4, Guo-Ze Wang5 and Bing-bo Chen1,*
... Then the Sprague-Dawley rats were fed by normal feed and 4 different BFA feed for 4 weeks. It was observed that the counts of neutrophils, white blood cells, and monocytes was significantly decreased in the lactobacillus BFA group than the control group (P<0.05); neutrophil was reduced in bacillus BFA group than the control group significantly (P<0.05). Compared to the control group, total protein, albumin, and albumin/globulin ratio were increased in l...
Shaher Bano1, Nadia Naseem2 and Sarah Ghafoor1,*
...andibular gland (SMG) of rats and humans is well-studied.However, less is known regarding post-natal sublingual salivary gland (SLG) development and expression of TGF-α. The comparison of TGF-α expression in SLG with that of its expression in SMG during post-natal rat salivary gland development has not been documented in the literature so far. Following ethical approval, a total of twelve rats were divided into t...
Pin Lyu1, Xiangxian Chen2* andQinlong Liu3*
...on. In this study, adult rats were divided into four groups namely natural healing (control), exercise and massage, massage only and exercise only and received acute skeletal contusion to the right tibialis anterior, followed by corresponding rehabilitation methods. The injured muscular tissues and blood samples were collected pre-injury and post-injury on day 1, 2, 4, 6, 9, 12 and 15. The exercise and massage group showed the fastest recovery reflected by mus...
Hong Zhang1, Shu-Fen Han2, Jing Wang1, Shao-Kang Wang1, Gui-Ju Sun1 and Cheng-Kai Zhai1, *
...nd lipid accumulation in rats and the possible molecular mechanisms, 40 male Sprague-Dawley rats were randomly assigned to four different diets, including reference chow diet (RCD), high fat and cholesterol diet (HFCD), city diet (CD) and compound whole-grain diet (CWD). Serum lipid profiles and glucose level were examined after 8 weeks. The molecular mechanisms underlined the effects of CWD on lipid metabolism were investig...
Yan-Guo Han1,2, Jun-Hua Ye1, Qin-Tao Zhao1, Yong-Jie Huang2, Kai Li2, Yong-Fu Huang2 and Li Xu1,*
...n promoting lactation of rats. Fifteen female SD rats were randomly divided into three groups and were orally vaccinated, respectively SS-14 (Group T1) and SS-28 (Group T2) DNA vaccines fused tPA signal peptide and CpG adjuvant and delivered by attenuated Salmonella choleraesuis at weeks 0, 3 and 6 of the study, and rats in control group (Group C) ...
Muhammad Naveed Sheas1, Haris Rasool2, Muhammad Nouman Rafique2, Muhammad Rizwan Tariq1*, Abid Muhammad1, Khubaib Ali1
...at model. 24 male wister rats were randomly divided into 4 groups. After the trial, blood biochemistry was done in which antioxidant enzymes like SOD, Catalyze, Glutathione peroxidase were performed that shows significantly high levels in the blood than the group that was treated with nicotine and shows a positive correlation with the days at which the rat’s groups were given a supplemented feed. Total antioxidant capacity and antioxidative stress shows ...
Uzma Jabeen1, Irfan Khan2, Nadia Naeem2, Asmat Salim2,* and Waseem Ahmed1
...ng DOX administration to rats. In this study, DOX was administered to rats intraperitoneally (i. p.) at 3 mg/kg at alternate days for two weeks. Heart and liver tissues were harvested and the mRNA levels of NAD(P)H quinone dehydrogenase 1 (Nqo1), glutathione peroxidase (Gpx1) and isocitrate dehydrogenase-1 (Idh1) were analyzed by RT-PCR. We observedvariable pattern of gene expression was observed. Nqo1 and Idh1 genes were up...
Zeynep Soyer Sarıca1*, Meryem Eren2 and Meryem Senturk2
...tissue of Sprague Dawley rats. Malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) enzymes were estimated in the brain tissues of the Sprague Dawley rats. Compared to the control groups, a significant increase in the brain tissue MDA level of the group which received only 10 mg/kg K2Cr2O7 was observed, whereas no statis...
Kun Wang1,2, Yinglin Cui2, Xu Zhao2 and Changjiang Hu1*
...ffect of XN on ICH model rats and to explore the underlying mechanisms of this therapy. In this study, experimental ICH was induced by the administration of stereotaxic collagenase type VII into the caudate nucleus. XN (at a high dose and a low dose of 3.60g·kg-1 and 1.80g·kg-1, respectively) was administered via enema. The detection of neuronal apoptosis was measured by TUNEL assay. Using immunofluorescence, the expression ...
Chukwuemeka Calistus Okolo1*, Ikenna Onyema Ezeh2, Chinelo Nnenna Uju3 and Nwakaego Ernestina Nweze1
...ypanosomosis. Thirty-six rats randomly assigned to six groups (A--F) were used for the experiment. Supplementation with multi-strain probiotics was started in groups A--C from day 0 post-supplementation (PS). On day 7 PS all experimental groups (A--E) were challenged with 1x106 trypanosomes intraperitoneally except the uninfected control (F). When parasitaemia peaked, groups A and B received 7mgKg-1 and 3.5mgKg-1 of diminazene aceturate (DA) respectively along...
Nouf Alharbi*, Mai Elobeid and Promy Virk
...perimental groups with 6 rats in each: Group I control orally received normal saline, Group II orally administrated cadmium chloride (5 mg/kg bw/d), Group III orally administrated cadmium chloride (5mg/kg bw/d) and treated with low dose of quercetin (50 mg/kg bw/d), Group IV orally administrated cadmium chloride (5mg/kg bw/d) and treated with high dose of quercetin (70 mg/kg bw/d). Experimental period was four weeks. The protective efficacy of quercetin was ev...
Shou-Hong Zhang1*, Ying Zhang1, Kun-Ming Wen2, Wei Wu3 and Wen-Yan Li3
... bile duct-ligated (BDL) rats. In addition, we investigated the staging of hepatic fibrosis by using Perfusion-Weighted Imaging (PWI). We established a BDL rat model of hepatic fibrosis. HGF carrier was administered through tail-vein injections. The gene therapy efficacy was evaluated in vivo. Before and after treatment the rats were examined with MR-PWI. The perfusion parameters of PWl were compared with the fibrosis...
Saman Muhsin Abdulkareem* and Nadir Mustafa Nanakali
...Thirty adult male Wistar rats randomly divided into five equal groups. TCDD and QCT were orally administered at the dose of 10µg/kg /day and 20 mg/kg/day, respectively by gavage dissolved in corn oil for 90 days. At the end of the study, animals were sacrificed and their liver were removed for biochemical analysis including the level of oxidative stress biomarkers, liver enzymes, and the expression of CYP1A1 gene. The results of this study indicat...
Kadry A. El-Bakry1, Lamiaa E.M. Deef1*, Lotfy Z. Habbak1 and Samia S. El-Naeli2
...o-renal toxicity in male rats. Rats were intraperitoneally (i.p) injected with PAT in a single dose (3.75mg/kg body weight). Rats were treated with ginger in a dose (100 mg/kg-1 body weight) for 4 weeks and 8 weeks. Blood samples for biochemical analysis and liver tissues were collected and fixed in 10% formalin for histopathological studies. The present study showed that, PAT causes eleva...
Sameh S. Tawfik, Ahmed A. Elkady* and Ehab T. Mohamed
...rotoxicity in irradiated rats was investigated. Forty albino-rats were divided into four groups: Control, rats were orally administered the vehicle for 6weeks, TSE-treated (each rat received 230mg TSE; once daily, for 6weeks), irradiated (animals subjected to whole body γ-rays (8Gy), and TSE-treated and irradiated (each rat received 230mg TSE; once daily for 6week, then one-hour late...
Tanveer Ahmad1, Tariq Mehmood1, Muhammad Shahid1, Adnan Ahmad1,2, Muhammad Asim Raza Basra1, Muhammad Zia-ur-Rehman3* and Munawar Ali Munawar1
...s on Sprague Dawley (SD) rats at the dose of 20mg/kg using glibenclamide (GC). Among these synthesized pharmacophores, six compounds exhibited percentage reduction (20.47±2.54 to 44.97±2.16 %) and (20.79±1.55 to 37±2.94 %) in blood glucose level at 20mg/kg dose compared to glibenclamide (74±3.10 % reduction) 50mg/kg dose of glibenclamide after 2 and 5 hours of oral administration respectively. Present results showed that thes...
Saara Ahmad1,*, Iftikhar Ahmed2, Saida Haider3, Zehra Batool4, Laraib Liaquat3, Fatima Ahmed5, Asra Khan1, Tahira Perveen3, Mirza Jawad ul Hasnain6, Saima Khaliq7 and Saad Bilal Ahmed8
...mption on liver cells of rats. One hundred and twenty female Albino Wistar rats were randomly divided into four groups and separately for standard chow rat, commercial chicken feed, commercial chicken meat and organic chicken meat over a six-week period. Plasma levels of tumor necrosis factor alpha (TNF-α) and alpha-fetoprotein (AFP) were estimated before and after the administration of different meals. After the exper...
Tian-Yi Zhao1, Zi-Qing Liu2, Shu-Fei Ma3, Bo-Yang1, Fan-Fan Guo1 and Ming-Hua Duan1*
...d memory abilities of AD rats, Morris water maze model was applied in vivo, and the activity of the NF-κB signaling pathway and concentrations of TNF-α, IL-6, and IL-1β were measured. The results demonstrated that biatractylolide can reduce apoptosis in hippocampal cells, prevent and improve the cognitive decline induced by Aβ, prevent the morphological changes in hippocampal nerve cells and can reduce the activation of NF-κB signal...
Rafia Sadaf1, Ishrat Younus2*, Sidra Maqbool2, Talha Bin Fayyaz3, Sarah Jameel Khan1, Sidra Siddique1 and Rida Fatima1
...d hole-board paradigm in rats at two different doses i.e. 250 and 500 mg/kg, and significant anxiolytic effects were observed as compare to control.
...
Ahmet Ozer Sehirli1,2, Serkan Sayiner3*, Ayliz Velioglu-Ogunc4, Nedime Serakinci5, Emel Eksioglu-Demiralp6, Berrak Yegen7, Feriha Ercan8 andGoksel Sener2
...al mass of Wistar albino rats was reduced at a rate of 5/6. Captopril, Valsartan and NAC were applied intra-peritoneal alone or in combination. Blood pressure and heart rate were monitored at weekly intervals over a period of six weeks. Serum creatinine, blood urea nitrogen (BUN), lactate dehydrogenase (LDH) activity, cytokines (TNF-α, IL-1β, IL-6) concentrations, urinary volume, creatinine, and both serum and urinary electrolyte levels were measure...
Jiao Qin,Qian-Qian Su and Quan-Sheng Liu*
...female lesser rice-field rats, Rattus losea. Results showed that the ovary weight of female rats treated with cabergoline significantly increased at day 24, but there were no notable changes in the uteri regardless dosage and time. PRL in female rats treated by 50 µg/kg cabergoline significantly was decreased by 56% at day 7 compared with the control. However, estradiol (E
Faruk Çolak1 and Ferhat Matur2,3,*
...n. The lesser blind mole rats (Nannospalax sp.) are obligate subterranean rodents known for their remarkable chromosomal variation. In the present study, we investigated whether the structure of seismic signalling is different between the two species found in Turkey, Nannospalax leucodon and the N. xanthodon and whether it is associated with ecological, sex, temporal and chromosomal peculiarities. A cytotype of N. leucodon (2n=
Magbolah Salem Helal Alzahrani
...onal status of liver, in rats injected with carbon tetrachloride (CCl4), a known hepatotoxin. Thirty-six male albino rats were treated with subcutaneous injection of CCl4 in paraffin oil 50% V/V (2ml/kg b. wt.) twice a week for 2 weeks to induce chronic liver damage. After injection of CCl4, blood samples were obtained using the retro-orbital method to confirm liver damage and estimate liver ...
Gregory Ejikeme Odo1,*, Juliana Ekenma Agwu1, Nkechi Nweze2, Clara Ikegbunam2,Felicia Ekeh N1, Vincent Ejere1, Ngozi Ezenwaji1, Reginald Njokuocha2, Godwin Ngwu1 and Fabian Okafor1
...>(L) in 48 albino wistar rats, Rattus norvegicususingbiochemical and haematological indicesof toxicity. ...
Faiqah Ramzan1,2,*, Irfan Zia Qureshi2 and Muhammad Haris Ramzan3
...rtal male Sprague Dawley rats, twice daily for 12 days, at three different dosage regimens: 10ρg, 1ηg and 1µg compared to control (saline-treated) rats. Effects on pituitary gonadotropins [Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH)], secretion of testosterone and spermatogenesis were evaluated on alternate day for one spermatogenic cycle. Major techniques applied were; radioimmunoassay, lig...
Xuya Zhou1, Ying Liu1, Deqin Xu1, Jie Bao1, Yaru Cao2 and Yong Jin3*
...s complicating arthritis rats. Blood pressure was measured by a noninvasive caudal artery blood pressure meter. Western blot analysis showed that unification of two drugs caused protein expression levels of COX-2 to reduce obviously and increased protein expression levels of CYP4A1. Immunohistochemistry showed the increased expression of CYP4A1. Elisa indicated that the decreased production of PGE-2 and the increased production of 20-HETE, ET-1 and BNP in bloo...
Ahmed Weli Hussein Osman1,2, Rakibul Islam1, Md. Bazlar Rashid1, Abdiaziz Idiris Mohamud2,3* and Pravin Mishra4
Nanoparticle Tactics for the Oral Delivery of Insulin in Alloxan-Induced Hyperglycemia in Rat (Rattus norvegicus domestica) Model
...n rat model. Twenty male rats of age four months were randomly allocated into four different groups (T0, T1, T2, and T3). After acclimatization diabetes was induced in three groups of rats (T1; positive control, T2: insulin only insulin, and T3; insulin with nano particles) by administered alloxan injection at dose of 120mg/kg body weight intraperitoneally. Group T0 was kept for negative control while T1 was kept positive co...
Ying Liu1, Shankun Liu1, Hui Wang2 and Weihua Su2,*
...tozotocin induced GDM in rats and explores the possible mechanism of action. A total 36 female rats were caged into the male rats for the pregnancy, and 33 female pregnant rats were collected and weight. The female rats were group into following groups and each group contains 6 rats....
Eman A. Al-Shahari1,2, Abdelhalim A. Alkhazendar3, Eman R. ElBealy4 and Abeer A. Alm-Eldeen3*
...mples from 30-months old rats’ testis were examined before and after 200 mg of quercetin/Kg administration. Before quercetin administration, they showed an increase in the lipid peroxidation and 8-hydroxy-2’-deoxyguanosine while showed a decrease in the superoxide dismutase activity, testosterone level and sperm count and viability. Seminiferous tubules diameters were 84.3 ± 5.6 µm and their epithelium heights were 21.2 ± 3.4 &m...
Qiang Tang1 and Qianli Tang2*
...wound healing in scalded rats. The results show that at 24 h after the last administration, wound healing rate of isoliquiritin group was higher than that of model group (p=0.024). Compared with control group, thickness of epidermis and dermis in model group was thinner (p<0.001), and width of subdermal collagen fibers also decreased (p<0.001), inflammatory factors TNF-α, IL-6 and IL-1β in skin tissue increased (all p
Hagar E. Mohammed1, Ranwa A. Elrayess2 and Heba N. Gad El-Hak2*
...n male fertility.Treated rats with different doses of A. monosperma or M. piperita alone induced severe testes histopathological lesions and histochemical alteration associated with a reduction in epididymis weight, abnormality in the sperm indices and a decline in serum testosterone levels which may have a bad impact on male infertility, on the other side, treatment the rats with the combined extract of differ...
Xiujun Yao1, Haofeng Wang 2, Ligong Zhang3, Jingzhang Wu4 and Lijun Wang1*
...e: small;">Ten out of 30 rats were randomly selected as normal group. Remaining 20 rats were used to establish rat model of mesangial proliferative glomerulonephritis (MsPGN), and were equally divided into model group and total glucoside of paeony (TGP) group. TGP group was given 150 mg/kg TGP by gavage, normal group and model group were given the same amount of saline by gavage. After 12 weeks of intervention, 24-h urine pr...
Ramazan Erdogan1*, Mikail Tel2, Vedat Cinar2 and Ragip Pala2
...-1) in adipose tissue of rats fed on zinc picolinate supplement diet. A total of 42 male 8-week-old Wistar albino rats were randomly divided into 6 groups, each of seven; Control (C), Zinc picolinate (ZP), Chronic exercise (CE), Chronic exercise+Zin picolinate (CE+ZP), Acute exercise (AE), Acute exercise+Zinc picolinate (AE+ZP). Rats were subjected to a 30-min running test 5 days a week fo...
Meiping Deng1, Xiaowen Ye1, Jiashan Wu1, Lijuan Chen1, Xiaoxia Jiang1, Changzheng Zhang1, Peiling Zhou1* and Yi Luo2*
...y characteristics. After rats were anaesthetized, saline or arecoline was intravenously administrated, and the systemic BP signals were recorded. We calculated the reaction times, the mean arterial pressure (MAP), the maximum changes in MAP, and the area under the curve (AUC; MAP change relative to the reaction time) due to arecoline stimulations. The results showed that arecoline induced biphasic modulations in BP, including an initial downregulation (Period ...
Amr N. El-Shahat1, Refaat G. Hamza1,*, Ashraf M. Mounir1 and Madeha N. Al-Seeni2
...nd kidney of male albino rats.In the present study, gamma- irradiation (2 Gy every 3 days up to 8 Gy total doses) induced biochemical and oxidative damage in rats when compared to control group. In GFJ (10ml/Kg B Wt. /day) treated irradiated group, there were noticeable decreases recorded in lipid contents, concentration of serum urea, creatinine and uric acid, glucose level, activity of some liver enzymes and liver and kidn...
Abdullah Abdo Albegali1, Tayyaba Aftab1, Atiq-ur-Rehman1*, Amir Rashid1 and Mayada Mohammad1,2
...lipidaemia Wistar albino rats induced by Triton X-100. There were 4 groups of rats: Group A served as normal; Group B, C and D were given high cholesterol diet and administered with intraperitoneal injection of Triton X-100 to induce hyperlipidaemia. Group B was administered with distilled water and high cholesterol diet on daily basis during the whole treatment and served as hyperlipidaemia control group. Group C was kept a...
Wassan Mhammed Husain1*, Zainab Sattar Ali2
...reated and healthy adult rats. Twenty-four adult rats were randomly divided into four groups and given the following treatments for 28 days: G1: as a control, the animals were oral administration with DW. G2: healthy rats were given 0.035 mg/kg BW of Phitofert ® every day by gavage. G3: twice a week, they were given 500 mg/kg B.W. of CCL4 mixed with an equivalent volume of olive oil (o...
A.M. Abdul Azeem, Ashraf M. Mounir and Amr N. El-Shahat*
...wder (GPSDP) on diabetic rats. In this work, the level of total phenolic and total flavonoid contents of raw dried pumpkin seeds was significantly increase under the effect of γ-irradiation (10 kGy). The results showed that glucose and testicular malondialdehyde serum level and the activity of xanthine oxidase were elevated (P < 0.05) with obvious reduction in the concentration of insulin, total thyroid hormones triiodothyronin and thyroxine, leutiniz...
Juliet N. Ozioko1, Obinna V. Ayogu2, Benjamin O. Ezema1, Dilibe C. Uramah3 and Kingsley O. Omeje*,1
... albino rat. Twenty-five rats that weighed 98-168g were separated into five groups. Phytochemicals were quantified using standard methods. Alkaloids, flavonoids, tannins, saponnins and terpernoids were detected. The leaf extract had 0.415 % of alkaloids, 0.102 mg/TAEq of tannins, 0.211 mg/QEq of flavonoids and 0.360 mg/GAEq of phenolics. Phytol, oleic acids, hexadecanoic acids and octadecanoic acids were detected in the leaf extract by Gas Chomatography-Mass S...
Jie He* and Ren Yang
...t-align: justify;">Fifty rats were randomly divided into sham group, model group, propofol group, vitexin group and propofol + vitexin group,with 10 rats each group. Rat model of whole liver ischemia-reperfusion injury was established according to Pringle’s method. Results showed that compared with propofol group and vitexin group, levels of serum ALT, AST and LDH in propofol + vitexin group were reduced (P < 0.05),...
Safaa M. Barghash1*, Amani A. Hafez2
...ity after vaccination in rats against Pasteurella multocida. T. evansi-infected and non-infected Wester Albino rats immunized against pasteurellosis with two vaccines; one is commercial, and the other is a formalin-killed vaccine (prepared from a local strain), and subsequently challenged virulent P. multocida. The differences in the regulation of IFN-γ, TNF-α, IL12, IL6, and IL10 cytokine levels expression, were...
Aymen Mabrouk*
...anges. Adult male Wistar rats were treated with Pb (2000 ppm of Pb acetate in drinking water) and/or TQ (5 mg/kg/day, per os) for five weeks. Results obtained clearly showed that Pb intoxication significantly decreased the mean red blood cells, hemoglobin, hematocrit and platelets values, but significantly increased the white blood cells count. Interestingly, co-administration of TQ to the metal-treated animals corrected all the altered hematological parameter...
Ying Feng1 and Xuqun Pei2,*
...ry ability of MCAO model rats. RT-PCR and Western Blot method were used to detect the expression of autophagy and apoptosis genes in neurons. We found that patients with ischemic stroke suffered from different degrees of impaired glucose tolerance, and the HbA1c index of patients with impaired glucose regulation and diabetes was higher than that of the normal glycemic group at the beginning and 3 months after the onset. The proportion of LAA and SAO in the two...
Rana A. Ali1, Abd-Elraheim A. Elshater2, Heba A. Mohammed3*, Mahmoud Elshazly4
...carried out on 40 albino rats, and equally divided into 4 groups, (10 rats/group) as following: Group 1, animals served as control. Group 2, animals received STZ. Group3, animals received laser. Group 4, animals received STZ+ laser. After the experiment, blood samples were collected for biochemical analysis. Also, the pancreas was dissected for histopathology. Results: biochemically, there was a significant increase in hepa...
Min Li1, Shiwu Deng2*, Yiqian Peng3 and Hong Li2
...c diameter (LVESd) of SD rats were measured by echocardiography, and the mRNA expression level of peroxisome proliferator-activated receptor gamma co-activator 1-a (PGC1 a), superoxide dismutase (SOD2) and citrate synthase (Cs) were detected by real-time PCR. Ultrastructural changes of myocardial mitochondria were observed by transmission electron microscope. The activity of Caspase-3 in heart tissue of SD rats was measured,...
Uzma Jabeen1, Asmat Salim2*, Irfan Khan2, Nadia Naeem3 and Rubina Mushtaq4
...ng DOX administration to rats. DOX was administered to rats intraperitoneally at 3 mg/kg at alternate days for two weeks. Kidney tissues were harvested and the mRNA levels of glutathione peroxidase-1(Gpx1), NAD(P)H quinone dehydrogenase 1 (Nqo1), 24-dehydrocholesterol reductase (Dhcr24), dual oxidase 2 (Duox2), and isocitrate dehydrogenase-1 (Idh1) were analyzed in the kidney tissues by RT-PCR. Extent of injury was analyzed ...
Ahmed Alazzouni1, Ashraf Al-Brakati2,*, Sherif Rabie1, Mohamed Gabry1 and Basmaa Hassan1
...olv-induced leukaemia in rats and their ability to alleviate the histopathological alterations in the mesenteric lymph nodes (MLNs) and spleen. In this study 70 rats were divided into seven groups as follow: control, benzene (0.2 ml twice/week), Moringa oleifera (100 mg/kg), curcumin (300 mg/kg), green tea (350 mg/kg), combined green tea and curcumin, and cyclophosphamide (7.5 mg/kg) groups. All groups were treated for one m...
Xiuli Wang1, Cuilan Hu2 and Sen Ye3*
...rain function. Eighty SD rats were randomly divided into 4 groups: control group, infarction group, 4.5h thrombolysis group and 6h thrombolysis group. The postoperative body weight loss rate and neurological function change of each group were observed by body weight test and neurological function scores. The infarct volume and microvessel density of each group were detected by TTC staining and immunohistochemistry. The effects of thrombectomy on brain wave flu...
Haipeng Liu1, Xubin Jiao1, Xiangqing Li1 and Xinru Xu2*
... ovaries of 20 female SD rats were surgically resected. Four weeks after surgery, osteoporotic rat models were copied and randomly divided into a calcitriol group and a model group, with 10 rats in each group. The ovaries of another 10 rats were detached but not removed as a sham-operated group. After 12 weeks of continuous administration in each group of rats
Chuanfeng Fan1,2,*, Wenguo Feng1,3, Jingchang Yang1,2, Qingchao Chen1,2 and Yu Wang1,4
...four Sprague Dawley (SD) rats were randomly divided into normal control group, glutamate induced injury group and α-melanocyte stimulating hormone pretreatment group each with 8 rats, 16 eyes in each group. The content of neurotransmitter amino acids and the survival rate, apoptosis rate and mitochondrial membrane potential of the retinal nerve cells were compared between the three groups. According to our results the ...
Wei Cui1, Yanwei Du1, Lijuan Jiang1, Yan Wei1, Yuguo Li1, Wenfeng Zhang1* and Ling Zhang2*
Ahlam G. Khalifa1*, Walaa A. Moselhy1, Hanaa M. Mohammed2 and Khaled Abdou1
...n published. Male albino rats have been randomly divided into 4 identical groups. Group (I) had received only corn oil and acted as a control group. Group (II) had been given 3.855 mg/kg BW deltamethrin. Group (III) obtained deltamethrin loaded silica Nps at a dose of 8.795 mg/kg BW. The group (IV) obtained deltamethrin loaded chitosan Nps at a dose of 30.44 mg/kg BW. All remedies were administered by oral gavage 5 days a week for one month. The deltamethrin g...
Zhongxi Zhang1, Ping Zou2*, Jingfang Zhang1, Yujuan Zeng1 and Yujie Tang1
...er protein expression in rats with acute basilar artery occlusion. Sprague Dawley rats (n=180) were randomly divided into 6 groups, 30 in each group, which were sham operation group, model group, and intravenous thrombolysis for 0, 2, 4, and 6h groups. The rats were scored by Zea-Longa method. The effects of intravenous thrombolysis on brain injury and blood-brain barrier were detected by ...
Tao Ren1, Guiqiu Cao2, Xiao Han3, Feng Tan1, Qiaoli Chen4, Shicheng Yang5 and Haiyan Zhang6*
... experimental study, the rats were anesthetized and blood samples were collected to scrutinize the various parameters such as creatine kinase myocardial band (CK-MB), high-density lipoprotein (HDL), lactate dehydrogenase (LDH), creatine, troponin-T (TRT), cholesterol, C - reactive protein (CRP), and concentration of mitochondrial enzymes viz., Ca2+, Na+ and K+ ions were estimated in blood. Heart tissue was also isolated for caspase-3 activity. Our result showe...
Zahra Jamilah Sabrina1, Adrian Pearl Gunawan2, Beryl Reinaldo Chandra2, Ilham Pangestu Harwoko3, Johannes Marulitua Nainggolan4,Widi Nugroho1*
...om each rat. Twenty four rats were fractured at the right tibial bones and divided into four groups; control, micro-CHA, micro-CHA+PRP, and nano-CHA+PRP treatments. Characteristics of micro-CHA and nano-CHA were analysed using Particle Size Analyser (PSA), Fourier Transform Infrared Spectroscopy (FTIR), XRD (X-Ray Diffraction) and Scanning Electron Microscope (SEM). The course of fracture healings was analysed at 21 days post-treatment using Emery’s scor...
Emtenan M. Hanafi1*, Fouad M. Tawfeek2, Walid S. El Nattat1, Moetazza M. Alshafei3, Seham S. Kassem3, Kawkab A. Ahmed4, Enas N. Danial5, Hagar Elbakry3, Hoda S. El-Sayed2
...wentiy eight. adult male rats were divided into 4 equal groups. G1 received high fat diet (HFD), G2 received HFD and microencapsulated BL, G3 was supplemented by HFD plus encapsulated SP and BL. While G4 received basic diet as a control. After 2 months, animals were sacrificed. Results showed that SP had antimicrobial effect against pathogenic bacteria while, it kept probiotic bacteria alive. The animals fed on HFD showed elevated lipid profile, leptin, oxidat...
Asmaa Khamis1, Osama Abdalla1, Mohamed Hashem2, Noha Abdelnaeim1*
...icinal plant extracts on rats intoxicated with carbon tetrachloride (CCl4). A total of 60 male albino rats were equally distributed in six groups. The first group received purified water and was kept as a control. The second and third groups were given oral PN and PM (500 mg/kg/day) for 31 days, respectively. The fourth group was intraperitoneally injected with CCl4 (2 ml/kg/day) on days 15 and 16 of the experiment. The fift...
Dalia M. Aboelhassan1*, Inas S. Ghaly1, Noha E. Ibrahim2, Nermeen M. Shaffie3, Mariam G. Eshak1, Aboelfetoh M. Abdallah4, Ibrahim M. Farag1
...ty and histopathology in rats. In the genetic study, the assaying of expressions of IkBα and COX-1 genes in liver tissues, as well as the expressions of mdr1a and COX-1 genes in kidney tissues are evaluated. In addition, the histological architectures of these organs are examined. Bisphenol A (BPA) treatment causes over-expressions of the above mentioned genes, and induces massive damage to the histological architectures of liver and kidney tissues. In c...
Xiaowei Huang1, Jinji Wang1, Zhun Yu2, Minghua Duan1* and Zhe Lin1*
...al pathway in irradiated rats. Total 60 Sprague Dawley (SD) rats were randomly divided into 5 groups: the normal (normal saline), model (normal saline), and low, medium, high dose of ASP groups (9.0, 18.0 and 36.0 mg/mL, 2.0 mL/kg·d, intragastric gavage once a day for 14 days). On the 15th day, all other groups received 60Co γ-ray irradiation with a total dose of 4.0 Gy except the normal group. The levels of NO ...
Xiaojing Liu and Zhongxin Li*
...iabetic nephropathy (DN) rats and analyze its action on vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP-) 9 protein expression in kidney tissues, in order to reveal the mechanism of TSG. After 12 weeks of administration, compared with those in the DN modeling group, 24 h urine protein, serum creatinine (Scr), blood urea nitrogen (BUN), blood uric acid (UA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) signific...
Iqra Ejaz1, Saima Chaudhry2 and Sarah Ghafoor1*
...eeks. The 24 male Wistar rats were equally divided into two groups; six rats (group 1A) were injected with normal saline (control group) while 18 rats (groups 1B, 2A and 2B, experimental groups) were injected with bleomycin. The six rats of control group (1A) and the six rats of experimental group (1B) were sacrificed ...
Mohammed A. Almujtaba1, Turky Omar Asar2, Salma Naqvi3, Vikas Kumar4, Fahad A. Al-Abbasi1, Abdulbasit I. Al-Sieni1 and Firoz Anwar1*
...ed cardiac remodeling in rats. Male Wistar albino rats were divided into 4 groups (n=6) for 28 days of experimental protocol. Group-1 served as normal control (NC), group 2 as doxorubicin control (DC), group 3 as doxorubicin+ Zamzam treatment (DZ) and group 4 as Zamzam control (ZZ). Doxorubicin (1mg/ kg bw) was injected i.p. in DC and DZ groups on first day of study. NC and DC groups were at normal bottled water p.o., while ...
Hakan Kececi1*, Yasin Ozturk2, M. Bahaeddin Dortbudak3, Seda Yakut4, Gurdal Dagoglu5 and Merve Ozturk1
...d. The study involved 54 rats which were divided into a total of 9 groups including one control group. A single dose of cocklebur seed extract was provided by gavage after being concentrated by 2 ml for each animal (80 mg ATR/kg) except for those in the control group, and time-dependent hepatotoxic, nephrotoxic, hematological and biochemical effects were analyzed. No histopathological change was detected in the liver and kidney tissues of the
Eman A. Al-Shahari1,2, Eman R. ElBealy3, Abdelhalim A. Alkhazendar4 and Abeer A. Alm-Eldeen4*
...d structure in aged male rats. Forty eight male albino rats (3 and 30 months old) were used. Half of the rats at each age received 200 mg quercetin/Kg every other day for 2 weeks. Thirty months old rats showed a decrease in the liver AST, albumin, SOD, CAT and GPx while showed an increase in the liver ALT, plasma cholesterol and MDA comparing with 3 mont...
Chemoprotective Effect of Daphnetin against Benzene Induced Leukemia Cancer via Alteration of CYP2E1
Junling Liu, Chen Sun, Qiao Yu, Yanzhi Liang, Shanshan Lin and Meng Tian*
...zene induced leukemia in rats and explores the underlying mechanism. Benzene was used for the induction of leukemia in experimental rats. The rats were divided into different groups and received the daphnetin (12.5, 25 and 50 mg/kg). The body weight, haematological parameters, deoxyribonucleic acid (DNA) fragmentation and cell cycle regulatory parameter were also estimated. Reverse transcr...
Aysam Fayed1, Mohga A Ibrahem2, Soha A. Hassan3, Mohammed Abdalla Hussein4*, Tamer Roshdy1
...t weeks, 36 white albino rats weighing 197±10 g were selected at random to five groups: Group I was administered a regular diet; Group II was fed a high-fat diet; Group III was given a high-fat diet plus cranberry extract (75 mg/kg); Group IV was fed a high-fat diet with cranberry extract (150 mg/kg); and Group V was fed a high-fat diet plus metformin (500 mg/kg). The lipid profile was determined using blood samples, and liver tissue samples were used t...
Muhammad Sajid Hamid Akash1*, Hina Sharif1, Kanwal Rehman2, Sumbal Rasheed1 and Shagufta Kamal3
... disorder. Twenty Wistar rats were used for this study; one group was normal control (NC), second group was exposed to ATO only while the other two groups received metformin (MF) and RSV separately along with ATO. We measured serum levels of glycemic index biomarkers and carbohydrate metabolizing enzymes. Simultaneously, we also measured arsenic concentration in liver using HG-AAS technique. ATO exposed rats showed a signifi...
Shou-Dong Zhang1,2,3, Dao-Xin Liu1,2, Dan Mou1, Tong-Zuo Zhang2, Jian-Ping Su2 and Jiu-Xiang Xie1*
...es and inside nearby quadrats of zokor burrow systems on the Qinghai-Tibet Plateau. Based on human volunteer taste-testing, or assignment using the Chinese Materia Medica Monographs, we divided the collected plant species into four different taste groups (sweet, bitter, other-taste, and tasteless) and then compared Ei values to determine whether plant taste can affect zokor diet selection. A total of 124 burrow systems were analyzed and 103 plants were used in...
Ahmed H. Massoud1, Mohamed S. Ahmed2, Moustafa Saad-Allah1, Aly S. Derbalah1, Ashraf Albrakati3* and Ehab Kotb Elmahallawy4*
...xanil pesticides on male rats. Results of the present study demonstrated that low doses of malathion, metalaxyl and cymoxanil pesticides was asymptomatic and mostly showed insignificant histopathological changes in treated rats. The observed values of biochemical enzymes with these low-doses were near to the control ones, whereas medium and high doses treated rats exhibited adverse signs a...
Dhiya Altememy1, Mohammad Darvishi2*, Samira Shokri3, Saber Abbaszadeh4
...investigated in diabetic rats. Eight groups of 12 rats in any group were diabetic by intraperitoneal injection of alloxan. After the rats were anesthetized, 2cm2 wounds were created and inoculated with bacterial suspension of S. aureus (ATCC 12600) equivalent to the 0.5 MacFarland tube. The hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum, and their active ingredients incl...
Ashira Manzoor1, Imran Ahmad Khan1,2*, Muqadas Sadiq3, Muhammad Omer Iqbal4 and Shaukat Hussain Munawar5
...d myocardial ischemia in rats. Animals were divided into 5-groups each group consisting eight rats. Group-1 was given saline for 2 weeks and on 11th day DOX 18mg/kg was given intraperitoneally. Group-2, Group-3, Group-4 rats pre-treated orally with the leaf extract of C. colocynthis 250mg/kg, 500mg/kg, 750mg/kg respectively for 14 successive days and on 11th-day DOX was inoculated, while g...
Ekechukwu Esther1, Ohanu Chinenye1, Ossai Nelson1*, Elijah Okwuonu1, Hinmikaiye Funmilayo1, Ngene Innocent1, Andong Felix1, Ikegbunam Clara2, Echude Daniel1, Ekeh Felicia1 and Odo Gregory1
...ical indices of 54 Giant rats were studied for 42 days department of zoology laboratory of University of Nigeria, Nsukka. The rats were divided randomly into six groups of 0%, 10%, 20%, 30%, 40% and 50% C. cajan diet respectively, with a total of 9 giant rats in each group. The diets contained protein, fibre, ash, fat and sugar /energy. Feed efficiency increased in the
Jiahua Peng1,2, Shiyao Hua3* and Qian Wu4
...ossible mechanism. Forty rats were randomly divided into four group, the model groups each of 10 the control group, the DHEA group (low dose, 15 μg/kg/d) and the DHEA group (high dose, 30 μg/kg/d). DHEA subcutaneous injection was used to construct the PCOS model of the polycystic ovary syndrome (PCOS) model of rats. The general condition of rats (body weight, ovary weight) and ovaria...
Saydat Saad Abd El-Megeed1, Walaa Yehia El-Sayed1*, Tarek Khamis2
...nO NPs) were assessed in rats. ZnO NPs were characterized by transmission electron microscopy (TEM). Diabetes was induced by streptozotocin (STZ) -nicotinamide in rats, and some biochemical and molecular parameters were determined. The results revealed that ZnO NPs in combination with Empagliflozin suggestively declined the blood glucose levels, lipid profile, and liver and kidney functions. A reduction was recorded in malon...
Florence N. Nworah*, Nene O. Uchendu, Ifeoma F. Chukwuma*, Emmanuel C. Ossai and Emmanuel C. Ezeako
...uced myelosuppression in rats. Blood constituents were determined to identify the presence of vitamins and minerals. Thirty albino rats used were grouped into six comprising of five rats each and each group except group A was induced with cyclophosphamide. Group A received normal saline, group B remained untreated, group C, D, E and F were respectively treated with standard haematopoietic ...
Shahrokh Mojarradgandoukmolla* and Hasan Akan
...atological parameters in rats treated with ethanol. Phytochemical analysis of seeds and leaves of these taxa was performed by GC-MASs and their morphological evaluation was performed by SEM electron microscopy. Hematological and biochemical variables such as hepatic enzymes activity, glucose, lipid profile, ESR, CRP, renal function tests, and oxidative biomarkers were measured. Histological evaluation was also performed. Among the hematological parameters in t...
Farah Abid1,2, Mohammad Saleem1,3*, Tahir Maqbool4, Tania Ahmed Shakoori5, Faheem Hadi4, Tahir Muhammad4, Saira Aftab4, Yasir Hassan7 and Shabana Akhtar4,6*
...hirty-six healthy wister rats were chosen for in vivo experiments and divided into six groups. Arthritis was induced in rats using Complete Freund’s Adjuvant (CFA) and treated with different concentrations of E-AM (250, 500 or 750 mg/kg), and with standard treatment, piroxicam (10 mg/kg). Antioxidant assays (superoxide dismutase and catalase) and histopathological examination were performed to determine the values of v...
Shaolin Zeng, Shuai Yuan* and Kai Liu
...erfusion (I/R) injury in rats and its causative role. The differential expressions of miRNA in the rat myocardial tissue after post-ischemic treatment with sevoflurane were screened by miRNA expression profile chip. The potential targets of miR-26a-5p were predicted by application of Targetscan, microT-CDS, miRtargetLink and miRpathDB database. The luciferin reporter groups were used for verification. We detected the impact of miR-26a-5p expression content on ...
Nadia A Eltablawy1, Ibrahim El Tantawy El Sayed2, Hamed Mohamed Abdel Barry2, Marwa A. Ibrahim3*, Maha Nageib Ahmed Serag ElDein2
...-eight adult male Wistar rats were divided equally into six groups: control non-treated, Doxorubicin (DOX) challenge (rats were injected with 2.5 mg/kg of DOX in six injections over 2 weeks), TME was solely administered for four weeks, two weeks pre and two weeks co-administration of TME (100 mg/kg) with DOX as well as TME (100 mg/kg) and TME (200 mg /kg) were administered after two weeks of DOX injection. Results: A relati...
Lulu Ding, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Mengli Jiang and Jicang Wang*
... and kidney damage among rats were studied. Twenty-four male Sprague–Dawley rats were randomly divided into four groups: control group, Cd-treated group (1 mg/kg b.w. CdCl2), Nar-treated group (100 mg/kg b.w.), and Cd + Nar-treated group (1 mg/kg b.w. CdCl2 + 100 mg/kg b.w. Nar). They were treated for 4 weeks, and then the blood physiological and biochemical indicators were assessed. The levels of glutathione (GSH), ma...
Rinat Islamov*, Dinara Turegeldieva, Altyn Rysbekova, Kuralay Sarmantayeva, Victor Semenuyk
...from laboratory mice and rats were realtime polymerase chain reaction and enzyme-linked immunosorbent assay. A high prevalence of some pathogens among conventional laboratory animals used by some academic institutes and universities of Almaty has been shown. Rodentibacter pneumotropicus has been detected in the SPF animals, while no other pathogens from the FELASA list have been detected. The obtained results show the importance of not only regular health moni...
Rukhsana Anwar1*, Ammara Abd-Us-Sattar1, Afifa Noor2, Kanwal Ashiq1,3 and Shah Jahan4
...s to different groups of rats. CYP modulators were administered to respective groups for last 5 consecutive days. Real-time PCR analysis of hepatic CYP450 subtypes, CYP1A2, CYP2C9, and CYP3A4 was carried out. Moreover, phase II drug-metabolizing enzymes; GST-specific activity, total glutathione, superoxide dismutase, catalase, and malondialdehyde were determined in liver homogenates. The phytochemical analysis of extracts revealed the presence of many importan...
Owolabi Olutunmise Victoria1*, Saka Olusola Stephen2, Olashinde Oluwaseun Ruth1, Alli Smith Yemisi Rufina3
... Thirty (35) male wistar rats were divided into six (7) groups of five animals each to study the antidiabetic and antioxidative properties of young Cola acuminata leaves aqueous extract. Diabetes was induced using alloxan monohydrate.5 ml of normal saline was given to group I , group 2 received 5 mg/kg/ body weight of the standard drug glibenclamide, group 3 was given 140 mg/kg of alloxan while groups Young C. acuminata leaves aqueous extract was administered ...
Magda A. Eldomiaty1,2, Manal E. Elsawaf2, Soad S. Ali3, Heba El-Sayed Mostafa4,5*
...y-two adults male Wistar rats were included based on their forced swimming test behavior. The rats were divided into 4 groups. Group 1 was the control group, group II was the control exercise group, group III was the depression group, and group IV was the depression exercise group. The forced swimming protocol was used to induce depression, while the rat voluntary wheel was used for voluntary exercise. After scarification, e...
Esam A Razin1, Hassan Sobhy2, Tarek R. AboElnaga1, Asmaa A. Darwish1*, Rasha S. Mohammed1
... 28 parasite-free female rats were used, seven non-infected (control group (CG)), while the others were intraperitoneally injected with T. evansi and then equally divided into Trypanosoma Group (TG): which remained without treatment. Diminazene aceturate group (DAG): injected with Diminazene aceturate (3.5mg/kg) at 0, 14th, and 28th days. Basil group (BG): treated with essential oil of basil (850μL/kg) at 0, 14th, and 28th days. Blood samples were collected...
Lihang Wang, Qiling Chen, Tingsheng Lu, Shudan Yao, Xingwei Pu and Chunshan Luo*
...the spinal cord (T10) in rats and treated SCI was with MH or/and MPS immediately. Conduction of Basso-Beattie-Bresnahan (BBB) scores was on all rats at different time points after surgery. Subsequently harvest of the serum and the spinal cord tissues was behind euthanasia of rats. Detection of biochemical indicators, observation of cell apoptosis, and determination of Bax, Bcl-2, p38 MAPK ...
Amber Khalid1*, Amjad Rashid Kayani1, Muhammad Sajid Nadeem1, Muhammad Mushtaq1, Mirza Azhar Beg1 and Surrya Khanam2
...items in male and female rats. It is concluded that Indian gerbil damaged the cash crops of Pothwar. Therefore, preventive measures should be taken as part of integrated pest control program....
Yang Hu, Jingxin Ding, Beilei Xu, Xiangming Sun, Guoyu Li, Hui Song, Zheng Zong and Wenlan Li*
... study, 30 female Wistar rats were orally administered with TGs, and serum fingerprints of blood samples collected at 10 different times were established by UPLC-Q-TOF-MS analysis. The estrogen-like activity of TGs was evaluated by determining the proliferation rate of Michigan Cancer Foundation-7 cells. The spectrum-effect relationship was analyzed by serum fingerprint of TGs to characterize the activity in vivo and identify the active compounds of TGs. In th...
Safaa Rhaimi1, Sara Brikat2, Mouloud Lamtai2*, Mohammed Ouhssine1
...ial oil in female Wistar rats, and to explore the antidepressant-like and anxiolytic-like effects and memory enhancing of the safe dose of this essential oil. In this experiment, salvia officinalis essential oil was administered once by oral gavage to four groups of female Wistar rats (n=6) at three different doses; 1000, 2000 and 3000 mg/kg. During 14 days after dosing, a follow-up was carried out for the mortality, food an...
Oussama Zghari*, Mouloud Lamtai, Sofia Azirar, Mohamed Yassine El-Brouzi, Hajar Benmhammed, Aboubaker El-Hessni, Ali Ouichou, Abdelhalem Mesfioui
...ty and OS in male Wistar rats. Rats received an intraperitoneal and/or a single intrahippocampal injection of NaCl, MEL or AlCl3. Before two weeks of intrahippocampal surgery period, MEL (4 mg/kg) was intraperitoneally injected (Group II and Group IV). Thereafter, control group (group I) received 2 µl NaCl (0.9%) and groups III and IV received 2 µl AlCl3 (2 mg/kg) intracerebrally into the right ventral hippocampu...
Yisi Chen*, Jun Zhang and Fayin Li
...ction injury. Forty-five rats were randomly divided into three groups: blank group (untreated, 3 groups, n=15), isoflurane group (general anesthesia of plantar incision, inhalation of 2.5% isoflurane, 3 groups, n=15), propofol group (general anesthesia of plantar incision, intravenous infusion of propofol to the lateral tail vein through the implanted catheter with the infusion rate of 1.5 mg kg-1 min-1, 3 groups, n = 15). The paw withdrawal threshold was used...
Shaimaa A.Tawfik2,3, EL S.T. Awad1*, Hoda O.Abu Bakr1, Amira M.Gamal-Eldeen4, Esmat Ashour2, Ismail M.Ahmed1
... Methods: 40 male albino rats weighing 150-200g were divided equally into four groups 10/each. CSO (5% w/w) were administrated oral daily for 30 consecutive days. DOX treated groups were injected IP at a dose of 2.5 mg/kg trice weekly to be totally 15 mg/kg for two weeks. G1 Control, G2 CSO, G3 Doxorubicin, G4 CSO/DOX. Antioxidant activity, histopathological examination, immunohistochemical analysis of CYP3A4, MRP-1, and c-MYC proteins and expression of miRN...
Rahma Boukarine*, Leila Hamdi and Kamel Khelili
...nducted on Albino Wistar rats to investigate the antioxidant effect of Eruca sativa on the hepatic and renal profile damaged by xylene. Seventy rats were divided into seven equal groups and treated by gavage for 30 days as follows: Control group (C), group (CO), positive control group (RE) was received 350 mg / Kg bw of Eruca sativa aqueous extract (ESAE), 2 toxic groups X1 and X2 were treated with xylene at two doses 400 an...
Nawfal Hammadi Jasim1, Yasmeen Jassim Mohammed2 , Jala Amir Salman Alahmed1, Majdy Faisal Majeed3*
...cts of MPH on adult male rats have been evaluated in this study. Materials and methods: receiving an oral dose (2 daily MPH doses), represented by Group 1 (5 mg/kg/day in a 5% glucose solution), Group 2 received daily dosages of methylphenidate in escalating amounts (5, 8, 12, and 16 mg/kg/day in a 5% of sucrose solution), as well as Group 3 as control animals ( 5% glucose solution). Group 1 resembled the therapeutic doses administered to humans, while Group ...
Rukhsana Anwar1*, Muhammad Usman Khalil1 and Kanwal Ashiq1,2
...e studied for 14 days in rats. Captopril (20 mg/kg) was given as a standard control. Non-invasive blood pressure (NIBP) monitoring technique was used to assess the blood pressure of rats. The frequency of hippuric acid synthesis from the hydrolysis of Hippuryl-L-Histidyl-L-Leucine was utilized to calculate angiotensin-converting enzyme (ACE) activity. The results showed that in comparison to hypertensive
Amr N. El-Shahat1*, A.M. Abdul Azeem1 and Mohamed H.M. Abd el Megid2
...c enzymes. Also, feeding rats on HCD with BLE enhance the antioxidant status in liver and heart tissues with indicated inhibition of lipid peroxidation by reducing the level of malondialdehyde compared to HCD-fed rats. The results concluded that BLE may have an effective role in reducing high cholesterol levels....
Sarwat Yousuf1, Shaista Emad2 , Mohammad Misbah ur Rehman3, Zehra Batool4, Sara Qadeer5, Yousra Sarfaraz1, Sheeza Sheikh1, Sana Sadaf6 and Tahira Perveen1,*
...lemon peel oil. However, rats administered with higher doses of lemon peel oil that act as prooxidants showed depression and anxiety-like effects, and impaired muscular strength. Altered brain antioxidant enzyme activity and elevated corticosterone in plasma were also observed in rats treated with a high dose of lemon peel oil. The present study demonstrates that a low dose of lemon peel oil has a potential therapeutic effec...
You-Ming Teng, Wen-Zhou Liu and Li Yang*
...n cardiac hypertrophy in rats. Rats with cardiac hypertrophy induced by renovascular hypertension were given a gavage of pioglitazone 5–10 mg/kg for 4 weeks. Our crew determined systolic blood pressure (SBP) and diastolic blood pressure (DBP). Heart mass index (HMI), left ventricular mass index (LVMI), myocardial cell diameter (MCD) and surface area (SA) were further estimated. We members determined FFA and Ang II leve...
Dalia M. Amin1*, Noha Mohammed Halloull1, Walaa E. Omar2, Basma A. Ibrahim2, Nahla M. Ibrahim1
Komal Javed1, Sohaib Muhammad1*, Zarghaam Khan1, Sehar Fatima1, Hassan Nawaz1, Mahrukh1, Tahira Khalid1 and Shariat Ullah2
...For each crop, sixty quadrats were taken from each village i.e., twenty quadrats from each selected site. The data was gathered after every fifteen days during the course of crop. For the determination of Importance Value Index (IVI) percentage frequency, density and percentage cover were determined. A total of 19 families were present in all three crops. Fumaria indica of Family Papaveraceae had the highest IVI value of 12....
Lianci He1, Dingxi Bai2, Chenxi Wu2, Yizhu Zhong2, Shi Chen2, Xinru Bao2, Jing Gao2*, Chaoming Hou2*
...Shenxian congee (SXC) in rats with chronic fatigue syndrome (CFS) on NF-κB signalling pathway and the expression of related factors. To reveal the relevant signal transduction mechanism in the treatment of CFS. Seventy two male SD rats were randomly divided into 6 groups with 12 rats in each group. Namely: control group (CON), low dose Shenxian Congee group (SXC-L), medium dose Shenx...
Maryam Beheshti1, Mohammad Reza Taheriyan2*, Sikander Shahzad3, Memoona Siddique4, He Tianwei5, Muhammad Farooq5*, Huzaifa Kashif6 and Naila Ilyas7*
...nsumption in the diet of rats....
Khalid M. Al-Syaad1,2
...induced toxicity in male rats. A total of 24 Wistar albino rats were included in this study, divided into four groups; each group containing 6 rats and administered the treatment doses orally by gavage for 28 days. Control, treated with a physiological solution (5.0 ml/rat). CC-treated group, treated with CC 15 mg/kg/bw. CC+propolis, treated with CC 15 mg/kg/bw + 30 mg/kg/bw propolis. Prop...
Rusul Adnan Dawood, Hasan F.K. Alghetaa*
...y, 8-10 weeks old female rats weighing 170-220 g were randomly grouped as following; control group (C) kept without any medication. Dimethyl sulfoxide (DMSO) used as vehicle to prepare RES treatment was given to D-group. RES administered to R-group. Challenge group of rats (HD) was administered HgCl2. The last group of rats (HR) was given HgCl2 with RES in the same doses mentioned earlier....
Muhammad Nasir Bhaya1,2* and Hikmet Keles2
...ed. For this purpose, 24 rats were divided into four groups, control, CP, CP+EA50, and CP+EA75. Histopathological examination of kidneys revealed hyperemia, epithelial degeneration, swelling, cystic dilatation and luminal proteinaceous material in tubuli, congested and hypercellular glomeruli and also inflammatory cells infiltration in the cortical and medullary area in CP group. Significant decrease of pathological lesions was found in CP+EA groups especially...
Chen Zhao, Lulu Ding, Ying Ye, Congying Kou, Haoran Xiao, Jing Zhu and Jicang Wang*
...adverse effects of Cd on rats and other animals, but the mechanism of Cd-induced autophagy in the kidney and the antagonistic effect of Nar on Cd are still unclear. In this study, SD rats were treated with Cd and/or Nar to investigate the protective effect of Nar on Cd-induced toxicity. The rats were treated for 4 weeks. The histopathological observation, oxidative stress index and autopha...
Reza Esmaealzade Dizaji1, Arasb Dabbagh Moghaddam1*, Arash Ghalyanchi Langeroudi2, Mohamad Foad Heydari3, Seyyed Javad Hosseini Shokouh4 and Ana Shirzad Shahrivar5
Tahir Rasool Qamar1, Sanaullah Iqbal1*, Muhammad Nasir1 and Habib-ur- Rehman2
...raw form, against CRC in rats. After acclimatization period, forty male Wistar rats were randomly and equally divided into four groups. Chicory powder treatments were started to group G4 before administering carcinogenic injections. After one-month, groups G2-G4 received four subcutaneous injections of carcinogen 1,2-dimethylhydrazine dihydrochloride (DMH) at dose of 40 mg/kg body weight, twice a week for 2 weeks. After DHM ...
A.M. Abdul Azeem1, A.N. El shahat1* and Mohamed H.M. Abd el Megid2
...isphenol A (BPA) in male rats. In this work, Citrus paradise peels extract used for reduction of sodium selenite (Na2SeO3) to reduce Se ions to Se0 confirmed by changing the colour of the solution from light yellow to red. The synthesized SeNPs were characterized by Ultraviolet-visible spectroscopy (UV-Vis spectra), Fourier transform infra-red (FTIR) spectroscopy analysis and Transmission Electron Microscope (TEM). The rats ...
A.M. Abdul Azeem1, A.N. El shahat1* and Mohamed H.M. Abd el Megid2
...isphenol A (BPA) in male rats. In this work, Citrus paradise peels extract used for reduction of sodium selenite (Na2SeO3) to reduce Se ions to Se0 confirmed by changing the colour of the solution from light yellow to red. The synthesized SeNPs were characterized by Ultraviolet-visible spectroscopy (UV-Vis spectra), Fourier transform infra-red (FTIR) spectroscopy analysis and Transmission Electron Microscope (TEM). The rats ...
Xiaowei Huang, Yajie Wang, Jia Zhou, Junxiu Liu, Zhe Lin and Ruili Li*
...intraperitoneally. 60 SD rats were randomly divided into 6 groups, control, model, positive drug (compound E-jiao slurry), SBG high-, medium- and low-dose (SBG-H, SBG-M, SBG-L) groups. After 21 days of intervention, the changes of thymus and spleen indexs were compared, the levels of white blood cell (WBC), red blood cell (RBC), hemoglobin (Hb), hematocrit (HCT) and platelet count (PLT) in peripheral blood were detected, and the changes of hemorheology were ob...
Nida Sadaqat1, Sheheyar Ahmed Khan1, Amna Bibi1, Sadaf Zahra1, Muhammad faisal Salamt1, Noreen Latief2 and Fatima Ali1*
...st-burn stage in scalded rats. Twenty-four male Sprague-Dawley rats were anesthetized and dorsum was shaved. Second-degree skin burn was induced by immersing an iron mold (1.0 cm2 in diameter) in boiling (100°C) water for 5 min and placed on the back of the rats for 20 sec without applying pressure. Rats were divided into three groups; control group,...
Fatima Ali1*, Rimsha Tahir1 and Tahir Rehman Samiullah2
... of excisional wounds in rats. Sprague Dawley (SD) rats were inflicted with excisional wounds. Wounds were treated with honey as control group and in combinations with 1%, 3% and 5% NAC. Wound area was measured after 3rd, 7th, 10th and 14th day. Improvement in wound healing was also confirmed by analyzing angiogenesis, apoptosis and chemotaxis genes. A significant increase was observed in the percentage of wound contraction ...
Fatimah A. Al-Saeed
...) leaves extract on male rats exposed to Cd (15 mg/kg body weight (b.w.). The male rats were randomly assigned to four groups. The first group served as control (CTL) that orally administered saline solution. The second group was exposed to Cd in a dose of 15 mg/kg b.w. The third group was treated with olive leaves extract (600 mg/kg b.w.) and exposed to Cd. The fourth group was treated with olive leaves extract (600 mg/kg b...
Salma Jameel Askar
...arameters in albino male rats and to determine the effects of Beetroots ethanolic extract in alleviation these alterations. Eighteen male albino rats were used, and they were divided into three groups of six animals each: G1, which received a dose of distilled water as a negative control; G2, which received a dose of meloxicam at 1.3 mg/kg.BW was a positive control, and G3 received a dose of meloxicam and beetroots ethanolic...
Physiological Effect of Glycyrrhizic Acid on Adrenal Insufficiency Induces by Glucocorticoid in Rats
Wafaa AL. Bnyean1,2 ,Zainab A.H. AL-Mousawi1*
...lucocorticoids in female rats. Fifty female rats were divided randomly into five groups. Negative control group(G1): Normal saline was given orally to rats. Positive control group(G2): rats for seven days were treated with Hydrocortisone Sodium I.P. (50 mg/kg). Therapeutic group(G3): rats for seven days were treated wi...
Tehreem Iqbal1, Roheela Yasmeen1* and Faheem Hafeez2
...A induced Sprague Dawley rats. In the study Sprague Dawley rats of an average 300 gram body weigt were used. The rats were divided into control and treated groups. The control group was comprised of normal control (C; untreated), vehicle control (P; treated with 1ml olive oil), and positive control (BG1; only treated with BPA). Treated groups were included the pretreated group (CG2; pretre...
Aryaf Mahmood Sabea1*, Majida A. Al-Qaiym2
...ession of hypothyroidism rats. Forty four female Wister rats of 3-4 months aged were equally and randomly divided into 5 groups except the control, which contains 8 rats. The 2nd, 3rd, 4th, and 5th groups were subjected to hypothyroidism by oral intubation of 0.02% Methimazole daily for 4 weeks. Treatments of 3rd with Sc-SeNPs (0.1mg selenium /kg/ day) as T1, 4th with Levothyroxine (0.9 &m...
Mustafa M. Khalaf*, Rana A. Salih
...Twenty-eight male Westar rats (that weighed 200–250 g) were chosen at random and divided into four equal groups for this investigation. During the initial periods of acute exposure, the animals had treatment with quercetin (50 mg/kg) for 30 days on consecutive days. Cyclophosphamide (100 mg/kg) was administered intraperitoneally only on 10 and 30 days six hours after the final dosage of quercetin. After 24 hours, all of the animals were led into sacrific...
Zainab Sattar Ali* , Safa Azhar Razzaq , Layla Hammody Hashem
... blood had gathered from rats each three weeks for assessed the concentration value of FSH, LH, testosterone, and inhibin B hormone for each of groups above. At the termination of experiment were taken in from them specimen of testes for a purpose pathohistology study and assessed the percentage of DNA fragmentation. The current study observed damage in this sperms DNA and alteration of histopathological section. In addition reduction the levels of testosteron...
Ali Mosa Rashid Al-Yasari1, Zahid I. Mohammed2, Haider S. Almnehlawi3,4, Ali F Bargooth5, Nawar Jasim Alsalih1, Huda F. Hasan6*, Mohenned A Alsaadawi1
...ian camels to adult male rats that had been given STZ to induce diabetes. Three groups of ten adult male Albino rats each were created at random from the thirty total animals. Control group was given ordinary food and free water, the STZ-Diabetes group received one (ip) injection of streptozotocin (40 mg/kg), and the STZ-diabetes+Camels’ Milk group received a STZ injection (40 mg/kg) along with daily (ad libitum) bottl...
Ahmed Al-Hasnawi*, Wafaa Kadhim Jasim
..., blood samples from the rats were taken to measure MCV, MCH, MCHC, GST, GSH, and MDA levels. a liver sample was also taken for each of the aforementioned groups to be examined histopathological. According to the findings, azathioprine dramatically decreased the MCV, MCH, and MCHC blood test results as compared to the control group receiving only regular aloe vera, as well as the levels of the function liver enzymes GST and GSH. In contrast to the control grou...
Haneen Imad Al-Sultani1*, Ahmed Obaid Hussain1, Hazar Shakir Saleh2
...uvastatin in male albino rats. Thirty-two adult albino rats were used in the study. After acclimatization, the rats were randomly divided into four groups (8 rats in each group) as follows: The first control group was given normal saline solution, the second group 10 mg/kg rosuvastatin, the third group was given 20 mg/kg rosuvastatin, while the four...
Jasir Hakim Hidayah1,2, Yos Adi Prakoso2, Sitarina Widyarini3*
... used in this study. The rats were separated into P1 (sham-operated), P2 (ischemic stroke model (IS)), P3 (IS + 0.74 mg/kg BW of calabash), P4 (IS + 1.48 mg/kg BW of calabash), P5 (IS + 2.96 mg/kg BW of calabash). The P2 – P4 groups were artificially induced ischemic stroke using common carotid artery ligation for 4 hours. After 24 hours, the rats were treated twice daily using various doses of calabash for seven days....
Ghusoon Hasan Jadaan1*, Khalisa K. Khudair2
...cles (SiO2NPs) in female rats could be ameliorated by the administration of Curcumin Phytosome nanoparticles (CPNPs). Curcumin Phytosome NPs’ impact on dyslipidemia and inflammatory state in SiO2NPa-exposed female rats was investigated. Approximately 32 female rats were divided into four groups as follows: T1: was administered oral 200 mg/kg of SiO2NPs, T2: received oral SiO2NPs and ...
Sara H. Zughayyar*, Amer H. Gyad
...hirty male Albion Wistar rats randomized into six equal groups of five as follows: negative control (received distilled water), positive control (induced diarrhea with 2 ml castor oil), and experimental groups that received 2 ml castor oil followed by oral administration of different doses of Prosopis farcta L. fruit ethanolic extract (300 mg/kg, 400 mg/kg, and 500 mg/kg). A comparative group received castor oil along with loperamide (2.5 mg/kg) orally. The o...
Rana Mahmood Ahmad*, Orooba M.S. Ibrahim
...ose, eighteen adult male rats 200 ± 50 g at six months of age will be randomly divided into three groups, each containing six rats. Groups 2 and 3 were treated daily for 14 days from the day of Freund’s adjuvant injection with SaZnONPs and piroxicam at doses 2.5 and 5 mg/kg B.W., respectively, while (Group 1) was positive control. Blood samples were obtained using cardiac puncture at three time points during the...
Ying Chen1, Chao-Zheng Li2, Zhun Yu3, Jia Zhou4, Yan Xu4, Zhe Lin4, He Lin4* and Xiao-Wei Huang4*
...hanism of VAP on MIRI in rats. Total 90 male Sprague Dawley (SD) rats were divided into the control, model (MIRI), positive (Diltiazem, DLZ, 20 mg/kg), VAP high, medium, low dose (VAP 300, 200, and 100 mg/kg) groups. After 21 days of intragastric administration, the electrocardiogram (ECG) changes in each group were detected. The activities of lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) isoenzymes in serum, an...
Xiao-Wei Huang1,2, Mei-Li Liu1, Jin-Ji Wang1, Yue-Xin Liu3, Zhe Lin1, Chun-Shu Rong4* and Ji-Xiang Ren4*
...gnitive impairment (MCI) rats model, specifically by investigating the PI3K, AKT and mTOR pathway. The type and content of amino acids (AA) in VAP were determined using pre-column derivatization-high performance liquid chromatography (PD-HPLC). Wistar rats were randomly divided into 5 groups (n=10 per group): control, model, piracetam (PIR), VAPH (300 mg/kg VAP) and VAPL (200 mg/kg VAP) groups. After intragastric administrat...
Taidong Wang1, Xiaowei Huang1, Jian Huang2, Guangfu Lv3 and Zhe Lin1*
...alysis. Subsequently, 24 rats were randomly divided into control group, model group, wild high-dose group and wild low-dose group, 6 rats in each group. Results of in vivo experiments showed that high-dose group (P<0.01) and low-dose group (P<0.01) significantly decreased body temperature in rats; high-dose group significantly decreased TNF-α, IL-1β and IL-6 levels (P<0...
Abroo Fatima Qazi* and Din Muhammad Shaikh
... induced diabetic Wistar rats. Animal were assorted to five groups: negative control group A and positive control group B and experimental groups C, D and E. Experimental groups C, D and E received Omega-3-fatty acid supplemented food in 0.3g, 0.4g and 0.5g/kg bodyweight dosage for 12 weeks, respectively. These Omega-3-fatty acids treated rats showed significant decrease in blood glucose level and rise in serum insulin as co...
Amer Hakeem Chyad1, Omar S.I. Al-Janabi2*, Orooba Mohammed Saeed Ibrahim1, Najeeb Mohaamed Hussein3
...extract on the testes of rats. Fifty adult male rate were divided into five equal groups, and each group received thirty days of treatment. first group (G1). Gave only distilled water (negative control group). second group (G2). These animals were administered CP at a dose of 14.2 mg/kg/BW (positive control group). third party (G3). Gave only 200 mg/kg/B.W. of Chelidonium majus alcoholic extract and 14.2 mg/kg/B.W. of cyclophosphamide were administered orally ...
Rana Mahmood Ahmad*, Orooba Mohammed Maeed Ibrahim
...dults male Wistar albino rats, six months, weighing 200–250g, were used and randomly grouped as follows: Group 1 was kept as a positive control group without treatment. At the same time, Group 2 received clove oil extract orally (10 mg/kg B.W.). Group 3 received Piroxicam (5mg/kg B.W) orally. The anti-inflammatory activity of clove oil extracts and their efficacy in decreasing inflammation in chronic inflammatory models were evaluated using the cotton pe...
Ghusoon Hasan Jadaan1*, Khalisa K. Khudair2
...2NPs) exposure to female rats affected the oxidative state. Ultraviolet-visible (UV-VIS), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy were used to investigate SiO2NPs and Curcumin Phytosome nanoparticles (CPNPs). Intense surface plasmon resonance at 1041 nm revealed the formation of silica nanoparticles. The two bands at 326 and 422 nm were ascribed to CPNPs, and SEM examination of SiO2NPs and CPNPs showed that SiO2NP...
Estabraq Hayder Khayoon, Ammar Ahmed Abdulwahid*
...hirty mature male albino rats be used, (10/group), the control group (CC), animals were intubated with distilled water for 40 days, Group G1, rats received Acrylamide 5 mg/kg B.W. every day for 40 days by gavage needle, and Group G2, in this group animals got Acrylamide 5 mg/kg B.W. and Curcumin 100 mg/kg B.W. for 40 days by gavage needle as well. At the zero and the end times of the experiment, blood samples were taken usi...
Xiangmei Chen, Burie Bao* and Mo Degema
...ators in type 2 diabetic rats. For this study sixty male Wistar rats were randomly divided into a normal group, model group, metformin group, and low-, medium- and high-dose camel placenta groups. A high-fat and high-sugar feed combined with intraperitoneal injection of STZ dissolved in a citric acid-sodium citrate buffer was used to establish a rat model of hyperglycaemia. Metformin hydrochloride tablets were used as a posi...
Anisa Muthia Fakhira1, Madihah Madihah1, Susi Susanah2, Erick Khristian3, Ratu Safitri1*
...se levels in male Wistar rats (Rattus norvegicus). The study using 7 treatment groups with 4 replications. Iron dextran (ID) was administered intravenously in three 3-day intervals, with cumulative doses of 10, 20, 30, 40, 50, and 60 mg/kg BW, whether the control injected with physiological sodium chloride solution. The results of the study showed that both the necrosis score in pancreatic beta cells and fasting blood glucose levels demonstrated a dose-respons...
Noor A. Namaa*, Hayder A.N. Al-Zamely
...id. A total of 60 Wister rats were chosen, prepared, and divided equally into three groups: T1, T2, and negative control, which received only distilled water daily and no other treatment. T1 was given a daily dose of (500 mg/kg) of Ginseng extract, while T2 received a daily dose of 250 mg/kg of Ginseng NPs. After a 60-day experimental period, all study animals were put to sleep using chloroform to collect testis samples, which were then homogenized and measure...
Abdeljabbar Nassiri1, Mouloud Lamtai1*, Inssaf Berkiks1,2, Hajar Benmhammed1, Sidi Mohamed Coulibaly1,3, Miloud Chakit1, Laila Ibouzine-dine1, Abdelhalem Mesfioui1, Aboubaker El-Hessni1
...d cognitive disorders in rats. However, the short-term and long-term behavioral consequences of MD have not been examined in detail. Also, the mechanism by which MD causes these disorders is far from fully understood. Therefore, this study was designed to examine the impact of MD on anxiety- and depression-like behaviors and oxidative stress (OS) in the prefrontal cortex (PFC) of rats across different ages (adolescence, emer...
Peixia Yu1*, Lijun Bo2 and Xueyin Song1
...mia-reperfusion (I/R) in rats. 120 male rats (mean age = 3 months) were randomly assigned to six conditions: control group (group S), I/R group, normal saline (NS) I/R group, and low, medium and high dose Fen groups, where in high dose group: Fen1:2μg/kg; Fen2:4μg/kg; Fen3:6μg/kg. The measured items included heart rate (HR), mean arterial pressure (MAP), left ventricular developed pressure (LVDP), ±dp/dtmax, ...
Hilwah Nora1,2, Rajuddin2*, Hafizuddin3, Rachmad Suhanda4, M. Fathurrahman5
...n this study were Wistar rats (Rattus norvegicus) three-month-old males weighing 300 g. Rats were acclimatized for 7 days and given standard feed and water ad libitum. During the research, rats were given standard 552SP feed. A total of six rats were used in this study, then divided into two treatment groups, namely C1 (given standard feed and distilled ...
Sara Brikat, Mouloud Lamtai*, Miloud Chakit, Laila Ibouzine-Dine, Ilhame Fitah, Oumaima Abouyaala, Abdelhalem Mesfioui, Aboubaker El Hessni
...ose diet (HFD) in Wistar rats. 36 female Wistar rats aged 2 months and weighing 74 to 100 g were randomly divided into 6 groups as follows: 2 groups would receive a standard diet which a group serve as control and a group receive 100 mg/kg/d of Curc and 30 mg/kg/d of Losartan (Curc + Los), 4 groups would receive the high HFD diet: one group serve as control (HFD), a group will receive 100 mg/kg/day of Curc, qualified (HFD + ...
Ghaith Z. Hasan Al-Askari *, Eman H. Yousif Al-Taee
...) of VD in female albino rats and to assess the effects of vitamin D (VD) on the severity of acute upper or chronic vitamin D intoxication (VDI) through the study of cytogenetic effects in addition to histopathological changes in the tissues of female rats. The methods included in the first experiment, the female rats were orally administered the following lethal doses: 0.5, 1, 1.5, 2, 2.5...
Taghreed Jabbar Humadai*, Bushra Ibrahim AL-Kaisei
... harmful toxic effect on rats that reflected on oxidative stress and increase IL1 and TNF alpha expression also induce hypospermatogenisis in testes and sperm stasis in epididymis. So, the objective of the present study was to evaluate the toxic effect of tetrodotoxin on the histological structure of male reproductive system and oxidative stress induction in male albino rats. The methods included sixty male albino
ASIFA BASHIR1, AAMIR MUSHTAQ2* & TOOBA MEHBOOB3
...lucose level in diabetic rats up to 166 ± 0.7 mg/dl on day 8th at 8th h as compared to diabetic rats 380 ± 0.7 mg/dl. Similarly, it also reduced the weight in rats up to 274.11 ± 0.97 g as compared to 310.71 ± 0.57 g which was recorded before treatment. It was thus concluded that Phyllanthus emblica is a potent antioxidant and antidiabetic agent....
Floral and edaphic data recorded from Sahiwal District, Pakistan analyzed by multivariate techniques
*ARIFA ZEREEN1, ALMAS JAHAN1,SHEIKH SAEED AHMAD2 & ZAHEER-UD-DIN KHAN3
... obtained from forty quadrats was compiled. Thirty eight plant species belonging to twenty one families were recorded. TWINSPAN bifurcated the flora of entire study zone into two main communities that had been again separated into smaller i.e., sub communities. Canonical correspondence analysis recognized the relation of vegetation assembly to underlying environmental factors. This correlation was studied by CANOCO analysis. In the Canonical correspondence ana...
HAFIZ MUHAMMAD ARSALAN1,2*, SUMMARA TABASSUM1, MUHAMMAD SHERAZ YASIN3, FAROOQ SALEEM4, ZEEMAL SEEMAB AMIN1, MUNIB ASHFAQ1, UMAR FAROOQ GOHAR5 & RASHIDA BASHIR6
...s induced in male albino rats by using Alloxan (150 mg/kg). Glutathione (GSH), Catalase (CAT), Malondialdehyde (MDA), Nitric oxide (NO), micronutrients (Vitamin A, Vitamin C and Vitamin E), serum glucose level and Advance glycation end products (AGE’s) were estimated. The results showed that levels of the Malondialdehyde (0.087, 0.151 and 0.104 respectively), Advance glycation end products (0.026, 0.053, 0.025) and Nitric oxide (0.07, 0.438, 0.190) were ...
Huda K. Khassaf1*, Zainab A.H. Al-Mousawi1, Sawsan A. Ali2, Anwar Nather Seiwan3
...olytes. A total of forty rats, weighing between 200-250 g at the beginning, were divided into three experimental groups at random: the control group, the SAL group which was given (80 mg/kg) of SAL orally for two days, and SAL plus ALA groups which was given (80 mg/kg) of SAL orally for two days, followed by 20 mg/kg of oral ALA for 28 days. The levels of the hormones TSH, T4, free T3 and free T4 were estimated. Also, total bilirubin (TB), Na+, K+, CL- and Ca+...
Youfang Li1, Xu Li2, Shaik Althaf Hussain3, Jayasimha Rayalu Daddam4 and Zhigang Chen5*
...t on male Sprague-Dawley rats, which were divided into seven groups i.e., Group 1 animals (controls) were fed regular chow and drank water ad libitum; group 2 animals were fed chow containing 3% sodium oxalate with the administration of gentamicin (40 mg/kg) and drank water ad libitum; group 3-7 animals were fed the same diet as group 2 with gentamicin administration and administered with standard drug i.e., allopurinol, EGCG, quercetin and EGCG: quercetin (1:...
Wasan Ali Hasan1*, Manal Abdulkhaliq Ibrahim2
...piratory inflammation in rats. Thirty adult male albino rats were segmented into five distinct groups, each group comprising six rats (n=6). A_group (Negative Control) rats received distilled water only, without any drug; B_group (Positive Control) rats underwent ovalbumin sensitization and challenge of the airways; C_...
Taghreed Jabbar Humadai*, Bushra Ibrahim Al-Kaisei
... on liver of male albino rats. At the age of 8–9 weeks and weighing 190–200 gm, 60 male albino rats were separated into 3 groups: First group of 20 rats received distilled water and regular pellets. Second group of 20 rats received weekly injections of 0.5 µg/kg b.w. by I/P route, which was equivalent to 1/20 LD50 of tetrodotoxin. Third...
Samia S. Alkhalil1, Faisal Al-Sarraj2, Abeer S. Aloufi3, Zuhair M. Mohammedsaleh4, Mamdoh S. Moawadh4, Fayez M. Saleh5, Majid Al-Zahrani6, Waheeb Aggad7, Youssef S. Alghamdi8, Mutaib M. Mashraqi9, Saleh Alshamrani9 and
Mona H. Soliman10,11*
...toxicosis. A total of 40 rats were equally divided into the four groups. The first group (BD) was kept as control, treated with basal diet. In second group (AF), the rats were treated with aflatoxins (28 µg/kg BW). In the third group (AFBL) the rats were treated with aflatoxins (28 µg/g BW) and Bacillus licheniformis (1 × 108 cfu/mL). In the fourth group (BDBL) the
Abeer Alahmari1,2*
...ity caused by ethanol in rats. Male Sprague‒Dawley rats orally received 40% ethanol (3 g kg-1) and were then orally treated with (500 mg kg-1) AME daily for 30 days. Kidney function, oxidant and antioxidant status, and histopathology alterations in renal tissue were measured. Animals that received ethanol displayed nephrotoxicity, as confirmed by markedly increased serum creatinine, urea, and uric acid levels along with ...
Bushra AL-Khaqani, Amira Mohammed*
...valbumin (OVA) causes in rats. Current results revealed that RES improved significantly (P<0.05) allergic asthma attenuation by decreasing the number of infiltrated mononuclear cells in Bronchoalveolar Lavage Fluid (BALF) and non-significantly (P>0.05) the number of infiltrated mononuclear cells intraperitoneally. RES increased lung integrity by reducing Evans blue extravasation in the lung (P<0.05) and liver (P>0.05). Additionally, in the BALF, RE...
Abdelghafour El-Hamzaoui*, Mouloud Lamtai, Laila Ibouzine‑Dine, Sofia Azirar, Mohamed Yassine El-Brouzi, Ayoub Rezqaoui, Aboubaker El-Hessni, Abdelhalem Mesfioui
...behaviors in male Wistar rats, administering daily subcutaneous injections of four different doses 25, 50, 75, and 100 mg/kg of GBH while a control group received 0.9% NaCl. Based on behavioral tests (the open field, elevated cross maze, and forced swim), behavioral alterations were detected, specifically anxiety levels and depressive behavior. Simultaneously, hippocampal oxidative stress markers (catalase, nitric oxide, and lipid peroxidation) were assessed t...
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Dietary Moringa Leaf Supplementation Affects Heat-Stressed Broilers: II-Blood Metabolites, Antioxidant Activity and Meat Quality
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