Muhammad Zubair, Sajid Mahmood Sajid
... medicine. It causes the pituitary gland to release hormones needed to stimulate ovulation. Clomifene is useful in those who are infertile due to anovu- lation or oligoovulation. Clomifene inhibits estrogen receptors in the hypothalamus, inhibiting negative feedback of estrogen on gonadotropin release and leading to up-regulation of ovulation. It has useful effects on the reproduction of female in terms of reduction in puberty and ovulation induction. The bene...
Shakeel Ahmed* and Sarwat Jahan
...gulation of hypothalamus pituitary gonadal (HPG) axis has also been established. In the present study, we investigated the role of peripheral administration of neuromedin S (NMS) on adipokines (adiponectin, leptin and resistin) secretion in 48-h fasting and normal fed adult male Rhesus monkeys. After NMS administration plasma adipokines levels were determined in fed and fasting monkeys. Four intact adult male monkeys were used in this study. 50 nmol of NMS was...
Shazia Ali, Hizb Ullah and Sarwat Jahan*
...vealed that hypothalamic pituitary axis had proper production, other factors miught be involved in delaying the growth spurt.
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Sadia Munir1a, Asif Nadeem1a*, Maryam Javed1, Masroor Ellahi Babar2, Tanveer Hussain2, Wasim Shehzad1, Rajput Zahid Iqbal3 and Sidra Manzoor1
... mammals. Pit1 encodes a pituitary-specific transcription factor, which is involved in pituitary development and regulating the hormone expression in animals. In current study, Pit1 gene was screened for polymorphic sites in Sahiwal cattle. Samples from Sahiwal cattle breeds were sequenced using six set of primers. A total 15 polymorphisms; 12 in intronic and 3 in exonic region, were identified. The sequences of the a...
Shafaq Fatima*, Sumrin Sahar and Khalid Lone
...sumably interfering with pituitary-inter-renal axis.
...
Zhen-li Li1,2, Hui-fang Zhou2,*, Bo-ru Zhou2, Bei Liu2, Xiao-fei Jiang2 and Jian-ya Xu2
...and uterus, but also the pituitary, resulting in LPD. Bu Shen Zhu Yun formula (BSZYF) was developed by Professor Guicheng Xia, a “great master in TCM.” It effectively cures LPD, while its effect on the pituitary is unclear. In this study, we aimed to explore the effect of BSZYF on gonadotropins and gonadotropin-releasing hormone receptor (GnRHR) signaling transduction in mifepristone-induced LPD rats. To explore ...
Bei Liu1, Yanli Hong1, Huifang Zhou1,*, Zhenzhen Cao1, Shuang Zhang1, Jing Jin1, Miao Jiang1, Cunsi Shen2 and Jianjian Ji2
...Decoction (BSZYD) on rat pituitary cells (RFC), and to investigate the mechanism of BSZYD in treating infertility due to luteal phase defect (LPD), a GnRH-receptor (GnRHR) antagonized model of pituitary cells was established by using the blocking agent of Cetrorelix. The cells were treated with BSZYD-containing cerebrospinal fluid (CSF). Thus, a total of five groups of cells, including blank (+) group, Cetrorelix (+) group, ...
Sajida Sabahat1, Asif Nadeem1,*, Maryam Javed1, Muhammad Yasir Zahoor1, Shahid Nabeel1 and Abu Saeed Hashmi2
...ph cells of the anterior pituitary lobe and plays significant role in growth, development, metabolism, lactation, and reproduction. Growth hormone interact with GHRs and influence on metabolism and growth. Changes in GHR concentration affect signalling pathways, binding capacity and alters activity of GH. Therefore, the GH and GHR genes are considered important candidate genes. DNA samples of Marecha camel were collected from the Camel Breeding and Research St...
Wenping Hu1, Xiangyu Wang1, Xiaodi Sun2, Ran Di1, Qiuyue Liu1, Zhangyuan Pan1, Xiaofei Guo1, Xiaohan Cao1, Jinyu Wang2, Yingjie Zhang3, Mei Jin4, Yuze Yang5 and Mingxing Chu1*
...expression in uterus and pituitary gland increased in estrus of Small Tail Han sheep and Tan sheep. The TAC3 expression level in uterus might relate with estrus of sheep. Two mutations of TAC3 were found in intron 1 (C327T) and exon 2 (G1803A) separately. Although there were significant differences of C327T/G1803A genotype distributions in five different sheep breeds, it did not relate with the year-round estrus. The relationship between these po...
Expression Analysis of BMPR1B, BMP15, GDF9, Smad1, Smad5, and Smad9 in Rams with Different Fecundity
Weihao Chen1,2, Zhilong Tian2, Lin Ma2, Shangquan Gan3, Wei Sun1,4,* and Mingxing Chu2,*
...erebellum, hypothalamus, pituitary, testis, epididymis, vas deferens, and adrenal gland in high fecundity (Small Tail Han sheep) and low fecundity (Sunite sheep) rams. The results were as follows: BMPR1B, GDF9, Smad1, Smad5 and Smad9 were expressed in all selected tissues, but BMP15 was specifically expressed in the epididymis. Further study indicated that the expression of BMPRIB in the brain, hypothalamus,
Asim Faraz1*, Abdul Waheed1, Muhammad Mudasser Nazir2, Aneela Hameed3, Nasir Ali Tauqir4, Riaz Hussain Mirza1, Hafiz Muhammad Ishaq1, Rana Muhammad Bilal5
...cing: -0.1px;">Posterior pituitary releases a hormone named oxytocin (OT) that causes contraction of smaller ducts and myoepithelial cells surrounding the alveoli of mammary glands. The milking process is allowed to be managed by an exogenous OT by its vital role in neuro hormonal milk-ejection process. OT increases milk yield by &uarr...
Khayyam1*, Muhammad Zahid1, Naiz Ali2 and Qadeem Khan3
...roid diseases effect the pituitary-hypothalamic axis which needs to be further investigated to find the mechanism underlying it.
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Shakeel Ahmed* and Sarwat Jahan
...s released from anterior pituitary and directly or indirectly play very important role in regulation of HPG axis. In the present study the pathway of stimulatory role of NMS was investigated in the regulation of HPG axis. For this purpose, after NMS administration plasma testosterone (T) and growth hormone (GH) levels were determined in four normally fed and 48 hours fasted adult male rhesus monkeys.Fifty nmol (50 nmol)of NMS was injected through a cannula aff...
Faiqah Ramzan1,2,*, Irfan Zia Qureshi2 and Muhammad Haris Ramzan3
...chanisms that govern the pituitary-gonadal-axis. However, in sexually immature male mammals, the maturation of gonads is not clear yet. The current study tested the hypothesis that continuous kisspeptin administration suppresses gonadotropin and testosterone release and spermatogenesis. Intraperitoneal kisspeptin administration was carried out in 05 weeks old prepubertal male Sprague Dawley rats, twice daily for 12 days, at three different dosage regimens: 10&...
Tai-hua Jin1, An-gang Lou2,Jiu-xiu Ji1, Cheng-dou Cui2, Long-zheng Yu2 andLi-zeng Guan1*
...miR-1468 on GH in pituitary cells of Yanbian yellow cattle in this study. Real-time quantitative PCR (qPCR), Western blot, Targetscan and RNAhybrid analysis software and Dual-Luciferase reporter gene system was used to analyze the regulation mechanism between miR-1468 and GH. The results showed that the GH mRNA and protein level in pituitary cells of Yanbian yellow cattle could be significantly decreased...
Khlood G. Abdelkhalek*, Aly B. A. Badawy, Mohamed Fathi, Elshymaa A. Abdelnaby
...ectively. In conclusion, pituitary hormones (FSH and LH) and steroids (E2 and T) were changed around age of puberty that likely reflects their roles in regulation of spermatogenesis with the attainment of buck sexual developmental capacity.
Keywords | Estradiol, LH, FSH, Resistive index, Testosterone
...
Weihao Chen1, 2, Zhilong Tian1, Lin Ma1, Shangquan Gan3, Wei Sun2, 4* and Mingxing Chu1*
...erebellum, hypothalamus, pituitary, testis, epididymis, vas deferens and adrenal gland tissues in both breeds. The expression level of Clock and BMAL1 showed similar trends in the brain, cerebellum, hypothalamus, pituitary, testis and epididymis in both breeds. The expression levels of Clock, BMAL1, and Cry1 were significantly higher in the pituitary tiss...
Xiaoyun He1, Yongfu La2, Jinxin Wang1, Ran Di1, Qiuyue Liu1, Xiangyu Wang1, Wenping Hu1 and Mingxing Chu1*
...ing hormone (FSH) is the pituitary hormone that regulates gonadal function by Hypothalamic-Pituitary-Gonadal Axis (HPGA) in vertebrates. FSHR has the function of transmitting follicle-stimulating growth biological information in animal breeding activities. In this study, we analyzed the structure of FSHR gene’s promoter, expression regulation and the correlation between polymorphism with fecundity. The results s...
Arman Sayuti1, Hamdan Hamdan2, Miftahul Jannah3, Safriadi Safriadi3, Teuku Nasri3, Tongku Nizwan Siregar2*
...yze the effect of bovine pituitary extract (BPE) on increasing the number of offspring per birth and the concentration of steroids (estrogen and progesterone) in the local rabbits. In this study, we used 10 non pregnant rabbits that have given birth and were healthy clinically. All rabbits were randomly divided into two treatment groups, namely control group (K1) and treatment group (K2) where each group consist of five rabbits. The rabbits of K1 group were in...
Abdullah Channo1*, Asmatullah Kaka1, Qudratullah Kalwar2, Imdadullah Jamali3, Ghulam Jelani2, Muhammad Bakhsh4, Ghulam Nabi Dahri5 and Jai Parkash Goil6
... factors on hypothalamus-pituitary stalkand normal function of the ovarywhich leads to alteration in follicular development, ovulation, reduced reproductive performance, unsuccessful ovulation, increased interval between parturition and conception, low conception rate, decrease in calving rate, increase in number of inseminations at each conception and finally culling. The incidence of COD is ranges from 5-30%, due to the improper managemental system, and the ...
Ali Basim Abd Al-Hadi*, Tahreer Mohammed Al-Thuwaini, Mohammed Baqur Sahib Al-Shuhaib
...anspositions between the pituitary and the ovary play a crucial role in the reproductive traits of sheep. Genetic polymorphism of candidate genes is associated with economic traits. Follistatin (FST) gene is one of the most notable potential candidate genes linked to economic traits. This study aimed to assess the genetic variation of the FST gene and reproductive hormones in Awassi sheep. Genomic DNA was isolated from 232 sheep (123 with a single pregnancy an...
Xiaowei Huang1, Chao Ma1, He Lin1, Yuchen Wang1, Yan Xu1, Guangfu Lv2* and Zhe Lin1*
... can reduce hypothalamic-pituitary-adrenal (HPA) axis hyperfunction induced by CUMS, increase the expression level of BDNF related signal pathway proteins, improve hippocampal tissue damage, and thus play an antidepressant role by regulating the negative feedback of HPA....
Chen Gu1,2, Ze-Dong Xu1, Lin Chen1, Ming-Hui Gu1, Sheng-Mei Yang1, Ai-Qing Wang1, Bao-Fa Yin1* and Wan-Hong Wei1,2,3*
...ior and the hypothalamic-pituitary-adrenal (HPA) responses of Brandt’s vole (Lasiopodomys brandtii) offspring after their mothers had been repeatedly exposed to predator odors during pregnancy. We exposed pregnant Brandt’s voles to distilled water (DW, the control), rabbit odor (RO, non-predator odor), or cat odor (CO, predator odor) for 18 days (60 min/day). Once the offspring matured into adults, we exposed them to either rabbit odor or cat odor ...
Qingjin Li1,2, Zhiyuan Sui1,2, Jihu Zhang1,2, Zhishuai Zhang1,2 and Feng Xing1,2*
...ted in the hypothalamus, pituitary, ovary, uterus and oviduct in the three development periods of prepuberty, puberty, and postpuberty. The results showed that the coding region of CTSD gene of Duolang sheep had a full length of 1,239 bp, encoding 412 amino acids. The sequence of Duolang sheep CTSD was relatively similar to those of other mammals and was in line with evolutionary relationship. The mRNA of CTSD gene was expressed in all the tissues of Duolang s...
Waqas Alam1, Sar Zamin Khan1 and Rifat Ullah Khan2*
Physiological Effect of Glycyrrhizic Acid on Adrenal Insufficiency Induces by Glucocorticoid in Rats
Wafaa AL. Bnyean1,2 ,Zainab A.H. AL-Mousawi1*
...ortisone of hypothalamus pituitary adrenal axis hormones and reduces the free radicals. ...
Cut Intan Novita1,2, Kartini Eriani3, Amalia Sutriana4, Tongku Nizwan Siregar5,6*, Ni Wayan Karja7
...a cell follicles. Bovine pituitary has been proven as an effective substitute for the functions of FSH and LH in some studies related to superovulation due to its high content of both hormones. Therefore, this study aimed to determine the effect of bovine pituitary extract (BPE) supplementaion to vitrification media. A total of 18 ovaries were usedwhich was divided into two groups: the vitrification medium group without Bovi...
