Johanna Lindahl 1, 2
British Journal of Virology
...mergence. Several of the mechanism by which urban disease emergence is promoted also increase the risks of vector-borne diseases, and the mosquito-borne Dengue virus is one of the pathogens benefitting from this. The related virus Japanese encephalitis virus is the most important cause of mosquito-borne encephalitis in the world, and is maintained in avian reservoirs and amplified by pigs. The occasional spill-over of the virus into humans results in more than...
Sandeep Satapathy and Rupam Ghosh
...al intracellular defense mechanisms. Associated with IL-6 signalling is the expression acceleration of sequestrome 1(SQSTM1) / aggrosome and colocalization of HDAC6 to the cytoplasm. The key player HDAC6 is investigated for modelling several intracellular processes that come into action to bring out the viral clearance. The shuttling of HDAC6 takes place from nucleus to cytoplasm and vice versa controlling the overexpression of IFN-beta and ISGs which subseque...
Ye Liu2, Yulong Cong2, Yiming Shao1*
...s of Tat and its working mechanisms, this review exhibits the superior potential of Tat as immunoregulator on optimizing immune responses mediated by vaccines. These examples of selected studies will provide researchers some implications and inspirations for using HIV Tat to optimize immune responses of vaccines....
Kathryne E. Taylor1 and Karen L. Mossman1,2*
...f diverse functions, the mechanisms through which it produces these effects continue to be elusive. Recent investigations into the ability of ICP0 to block the activation of antiviral signaling have revealed a potential explanation for some of this confusion – namely, that ICP0 has important functions in the cytoplasm that have been generally disregarded, due to the fact that many frequently used experimental manipulations restrict this protein to the nu...
Derk Pereboom
...for by the conditions on mechanism-ownership, a feature of the compatibilist account of moral responsibility he and Ravizza (1998) developed, which, he correctly points out, I neglect in favor of the reasons-responsiveness component....
Weili Kong1, Guangpeng Ma2 and Jinhua Liu1*
...luenza virus by multiple mechanisms. Due to C-terminal ‘tail’ (CTT) truncation of NS1, there are length variation types of NS1 in different subtype influenza viruses. CTT functions in several ways to defeat the cellular innate immune responses. Here, we discuss those different effects of CTT truncation or elongation of NS1 protein in different genetic backgrounds of influenza experimentations. Conclusively, it can be stated that CTT confers a posit...
Luke Galen
...erature reveals that the mechanisms of most beneficial associations with religiosity are attributable to factors other than beliefs, chiefly, social engagement and embeddeness in supportive groups. Often, those with the lowest levels of well-being and prosociality are uncommitted or indifferent religious believers, not socially engaged nonbelievers. Therefore, defining individuals who are not committed or engaged in socially supportive groups solely in terms o...
Luca Vitale
...ns by means of different mechanisms that contribute to their adaptive success in different habitats....
Jonas Johansson Wensman1*a, Karl-Johan Leuchowius2,3 a, Jiting Yan1, Anna-Lena Berg4, Liv Bode5, Hanns Ludwig5, Sandor Belak6, Ulf Landegren2, Ola Soderberg2, Mikael Berg6
...rved, however, the exact mechanisms behind BDV’s ability to establish persistence despite a prominent immune response are not known. Here we have used in situ proximity ligation assay (in situ PLA), a selective tool for studying virus-host protein-protein interactions. BDV P (phosphoprotein) and N (nucleoprotein) have previously been reported to interact with several host proteins, thereby interfering with various signaling pathways. In this study, we fo...
Mukhtiar Ahmed, Jana Pickova, Taufiq Ahmad, Muhammad Liaquat, Abid Farid, Muhammad Jahangir
...urs by several molecular mechanisms such as generation of reactive oxygen precursors and free radicals. Oxidation affects many interactions among food constituents, leading to both desirable and undesirable products. Food lipids are the foods components that are most susceptible to oxidation, therefore oxidation reactions are one of the major sources of deterioration that occurs during manufacturing, storage, distribution and final preparation of foods. Lipid ...
Yingbin Wang*, Ting Ye, Xiaogang Wang and Congyu Zhou
... find out the underlying mechanisms....
Iqra Mahmood1, Asif Nadeem1*, Masroor Ellahi Babar2, Muhammad Muddassir Ali1, Maryam Javed1, Aisha Siddiqa1, Tanveer Hussain2 and Muhammad Tariq Pervez2
...tanding of the molecular mechanisms underlying the host immune response to the infectious agents is necessary. Identification of the genes, and their variants, involved in innate immune responses is essential for the understanding of this inflammatory disease and to identify potential genetic markers for resistance to mastitis. This article presents a systematic integration of complex biological interactions of 226 mammary gland genes to uncover underlying reg...
Metin Duru1*, Asuman Arslan Duru1, Köksal Karadaş2, Ecevit Eyduran3, Harun Cinli4 and Mohammad Masood Tariq5
...etter prove relationship mechanism between egg quality characteristics which are of great importance for higher price and more income of fertile and table eggs....
Jose M. Rojas, Noemi Sevilla and Veronica Martin
...o clearly understand the mechanisms developed by these viruses, in particular PPRV, to interact with the host immune system. A better comprehension of this behaviour could lead the global strategy for the control and eradicaton of PPR, initiated by Food and Agriculture Organization of the United Nations (FAO) and World Organisation for Animal Health (OIE) on 2015....
Jixue Hou1,2, Xueling Chen3, Jing Wang4, Hongwei Zhang2, Yu Xi2, Jie Xia2, Xinyu Peng2,* and Xiangwei Wu2,5*
...g the pathophysiological mechanisms to restenosis after percutaneous transluminal coronary angioplasty (PTCA) as well as translational approaches. In this Experiment, we established a unique murine model of femoral artery injury through a home-made wire. The mouse model of vascular injury may be used to explore the molecular mechanism of post-angioplasty restenosis with lowest costing....
Ibni Amin Khalil* and Raziuddin
... as non-additive genetic mechanisms were found important due to significant effects for both components i.e. General Combining Ability (GCA) and Specific Combining Ability (SCA) effects. Maximum GCA was shown by L-7 and T-1; whereas high SCA was noted for L-6 and L-7 with good ability to combine with T-3 and T-1 respectively, and could be utilized as genetic material in future breeding programs. Overall the biplot approach was found much cooperative in elabora...
Waqar Islam*1, 2, Madiha Zaynab3, Muhammad Qasim2 and Zujian Wu1,2
...to explain the molecular mechanisms involved in triggering the antiviral resistance in plants. Antiviral RNA silencing, R-gene mediated resistance and host factor related recessive resistance are categorized as most beneficial plant defense approaches used by plants. The review also briefly explains about introgression of durable resistance to generate virus resistant cultivars for economically important crops through molecular breeding techniques via utilizin...
Sung Kwon Park1a, Jin Young Jeong2a, Eun Seok Cho3, Yong Dae Jeong3 and Chang Seok Park4*
...r understand the precise mechanisms of PEDV in pig PBMC.
...
Xiang Nong1,2,3,*, Yao-jun Yang1,2, Guang-you Yang3, Feng-zheng Chen2, Mei Tang1,2 and Gang Wang2
...e insecticidal molecular mechanism of stigmasterol to lay the foundation for the development of stigmasterol as nontoxic and pollution-free pesticides that can be introduced into the environment.
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Sitansu Pan and Someshwar Bhagat
Biological control of plant diseases
...l of plant diseases. The mechanisms of action of these biocontrol agents against target pathogens are antibiosis, mycoparasitism, competition for space and nutrient, production of certain toxins and secondary metabolites, solublization and sequestration of immobilized plant nutrients, plant growth prowth promoting properties and induced resistance. Multiple interactions between bacteria-fungi-actinomycete, may exist in nature and that is why consortium of micr...
M. S. A. Mamun and M. Ahmed
Integrated pest management in tea: prospects and future strategies in Bangladesh
...varieties and mechanical mechanisms like manual removal, heat treatments, light traps, use of bio-pesticides, bio-control agents and sex pheromone trap need to be given more importance in pest management programme. A tentative IPM strategy for tea cultivation in Bangladesh has been proposed in this paper. Thus the proposed integrated pest management (IPM) strategy should help tea industry for successful long lasting plantations which will ensure consistent cro...
M.A. Pendse, P.P. Karwande and M.N. Limaye
Past, present and future of nematophagous fungi as bio-agent to control plant parasitic nematodes
...tion, trap formation and mechanism of nematode capture as well as probable causes of death. The review traces the shift in the areas of research as well as ups and downs in the interest shown by the researchers. Guide lines for organized, coordinated research to i) screen different strains of NF that are tolerant to antagonism by other fungi, and ii) develop a bioagent based on nematophagous fungi which will show consistent success for the controlling of phyto...
D.K. Hazra, Megha Pant, S.K. Raza and P. K. Patanjali
Formulation technology: key parameters for food safety with respect to agrochemicals use in crop protection
...volved in the pesticidal mechanism. This implies that most of the applied pesticides find their way as 'residue' in food chains where they undergo concentration and pro-duce potential, long term, adverse health effects. Pesticides in developing countries in Asia and Pacific region are mainly available as dust, wettable powder, emulsifiable concentrates, solutions, etc. These types of formulations are regarded now as ?conventional‘, ?old technology‘...
A. K. Ganguly and Uma Rao
Decades of researches in biochemical and molecular nematology at IARI
...h areas were biochemical mechanism of resistance against phytonematodes and diagnostics of economically important plant parasitic nematodes. Specific isozymes have been identified for differentiating the important root knot nematodes species of India belonging to the genus Meloiodogyne. Further, molecular markers like RAPDs, AFLP, SSRs and PCR–RFLP of rDNA have been employed to study the molecular genetic diversity in major root knot and cyst nematode sp...
Wenqiao Hui1, Jishun Tang1, Dejian Zhu1, Qian Ban2* and Sheng Chen1*
.... However, the molecular mechanism of puberty onset has not been well understood. It has been demonstrated leptin act as a critical metabolic cue linking adipose and the onset of puberty. In the present study, we first assessed the morphological changes in adipose tissue at pre-puberty and puberty onset stages of goats, and then determined the role of leptin to activate signaling pathways which modulate the expression of hypothalamic genes involved in reproduc...
Yun Wang1,*, Lei Guan1, Jiding Chen1, Yaping Kong1, Lang Si2 and Asif Shah3
...o improve the protection mechanism for the four large ungulates viz., Tibetan antelope Pantholops hodgsonii, Tibetan gazelle Procapra picticaudata, Kiang Equus kiang) and Wild Yak Bos grunniens; we suggest that the distance between the proposed route for the expressway and the present highway and railway should at least be 1500m, and ideally, it should be 2500m.
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Tiansen Li1, Meiling Huang2, Zhen Wang1,Fei Guo3,Hui Zhang1,* and Chuangfu Chen1,*
...cellosis. Currently, the mechanism behind the pathogenesis of Brucella remains unclear. For this reason omp10 mutant was constructed to examine the impacts of the outer membrane protein 10 (Omp10) on bacterial survival, virulence, phagosome-lysosome fusion, and apoptosis induction, as assessed in appropriate in vitro (cell culture) and animal models. Results showed the omp10 mutant was dramatically attenuated for survival in macroph...
Qudsia Khalid, Safdar Hussain Shah*, Faiza Zaeem and Saad Hussain Shah
...s some of the adaptation mechanism(s). Adapted calli line was obtained on MS medium supplemented with 2,4-D (2 mg/l) and kinetin (0.25 mg/l). For regeneration MS medium with 1.0mg/l NAA and BAP + 30g/l D-Sorbitol was used. LiCl adapted line showed significantly higher indices of tolerance than unadapted line at 100, 150, 200 and 250 mM NaCl stress. Adaptation resulted in enhanced accumulation of saturated fatty acids (myristic and stearic acids), while unsatur...
Mian Ahmad Raza*, Ghulam Hassan and Naqib Ullah Khan
...ance type of inheritance mechanism was involved in the expression for maturity trait, plant stature, spike length, spikelet spike-1 and grains spike-1. Negative intercept of regression line indicated the major role of over-dominance in the inheritance of plant height, spikelets spike-1while for grains spike-1 the positive intercept of regression line indicated predominance of partial dominance in inheritance.F1 cross combination FS × JNB were observed as...
Fang Wang, Yong-Fang Jia, Po Wang, Qi-Yan Du and Zhong-Jie Chang*
... to reveal the molecular mechanism by which LET caused sex reversal, juvenile carp (120dph) were exposed to 0, 5, 25, 125, and 625μg/L LET for 15 days, and the expression profiles of seven gonad differentiation related genes (Cyp19A, Cyp19B, Arα, ERα, Dax, Foxl2, Dmrt1) and gonad histological changes were examined. The results showed that LET could inhibit oocyte growth in female and promote the development of testes in males. For the gonad diff...
Nargis Bano and Khalid Mahmood Qureshi*
...that are involved in the mechanism of stress tolerance. SA is part of an extremely complex signal transduction network’s part and it works differently in different systems. Drought stress is a major restraint for crop production in arid and semi arid states such as Pakistan. In this study experiments were conducted against the responses of strawberry plant to both pre-harvest application of salicylic acid and drought treatments. The design of the experim...
Rabia Tahir1*, Khushi Muhammad1, Masood Rabbani1, Muti-u-Rehman Khan2, Farah Khan1, Hassan Bin Aslam1 and Arslan Mehboob3
...e lacking. The molecular mechanism and establishment of latent infections warrant future investigations to elucidate these discrepancies....
Saba Manzoor1,*, Ali Raza Awan1, Abdul Wajid1, Sehrish Firyal1, Muhammad Tayyab1, Muhammad Mansha2, Asim Khalid Mahmood3, Abu Saeed Hashmi1 and Muhammad Wasim1,*
...needed to understand the mechanism of tumor pathogenesis in animals in order to identify the molecular targets for proper cure of this ailment.
...
Rehana Shahida1, Tasnim Farasat1, Shagufta Naz1,* and Shahjahan2
...stance and the molecular mechanisms involved in the interaction of atherosclerosis and hyperglycemia within the context of chosen pro atherogenic parameters including plasma glucose level, serum levels of insulin, IL-6, and TNF-α. Serum level of thrombomodulin was assessed as a measure of vascular damage. Different demographic parameters as age, BMI, waist /hip ratio, B.P., personal history and socioeconomic status were recorded. Fasting glucose and HbA1...
Prof. Dr. Saira Afzal
...ally the quality control mechanism. Scientific discoveries and advancements have far reaching implications especially in health and medical publications. The quality assurance mechanism in medical journals has to be stringent and flawless. The peer review systems are continuously being criticized, debated and updated. It may be open peer review or blind peer review, both have advantages and disadvantages. Open peer review is...
Pei-feng Yin1,2,Xiu-xiu Li1,Qi-wei Zeng3, Cheng-chen Shen1, Le Gao1 andJian-zhang Ton2,*
...the molecular resistance mechanism of fruit mulberry “Da10” i.e., popcorn disease, Two-dimensional electrophoresis (2-DE), matrix-assisted laser desorption/ ionisation time-of-flight tandem mass spectrometry (MALDI-TOF-TOF MS) and bioinformatics technique were used for characterize the differential expressed proteins. Almost 78 patho-stress responsive proteins which expression level more than 1.5-fold were identified, where 50 proteins were ...
Guang-Xin E1, Yong-Ju Zhao1, Yue-Hui Ma2, Ming-Xing Chu2, Jia-Hua Zhang1, Zhong-Quan Zhao1, Hui-Jiang Gao2, Huai-Zhi Jiang3, Di Liu4, Li Liu5, Yan-Bin Zhu6, Wang-Dui Basang6, Luo-Bu Danjiu7, Tian-Wu An8, Xiao-Lin Luo8, Shi-Cheng He7 and Yong-Fu Huang1,*
...esearch on the molecular mechanisms of dominant follicle selection in goats. In this study, 90276370 and 115579236 clear reads in dominant and nondominant follicles of goat were generated through Illumina paired-end sequencing, and their mapping rate was 84.99% and 84.47%, respectively. A total of 12577 differentially expressed genes (DEGs) were identified, including 6009 upregulated and 6568 downregulated genes in dominant follicles compared with nondominant ...
Bian Xunguang1,2, Li Jiancheng1, Xu Chu1 and Yang Li2,3,4,*
...viduct and the molecular mechanism of sperm storage.
... 
Maryum Fakhar, Iqra Jabbar, Anjum Nasim Sabri*
...tegies involving several mechanisms of resistance and tolerance. Biofilm formation is one such resistance mechanism for bacterial survival. This paper provides the basis for use of bacteria isolated from saline environment and to check their biofilm forming ability under nickel stress. Our previous results showed that these bacteria are capable of producing proline, glycine betaine, choline and other osmolytes under NaCl str...
Soraya Khosravian Dehordi*, Abdolnaser Mohebbi and Kahin Shahanipour
...ss creates by the common mechanism their carcinogenicity and toxicity. The present study was planned to determine whether an oral administration of nano-selenium (nano-Se) influencing on biomarkers of oxidative status in the rats spleen exposed to the cadmium (Cd) metal. For this purpose, thirty male rats equally divided into six groups, group I received nano-Se (0.1mg/kg) alone as dose, group II selenite odium (0.1mg Se/kg) alone, group III Cd chloride (300mg...
Naheed Akhtar, Waseem A. Gillani, Ehsan ul Haq, Javed Khan, Irshad Begum, Shaheena Yasmin* and Kamran Saeed**
...nducted to determine the mechanisms of resistance like antixenosis, antibiosis and tolerance. Results indicated that the entry B-00080 had antibiosis and B-99036 was the tolerant one. So, on the basis of present studies the entry having high level of resistance against R. padi (B-99036) should be incorporated in the future breeding programmes....
Nazish Shaukat1, Muhammad Javed1,Faiza Ambreen2* and Fariha Latif1
...sive nature and adaptive mechanisms of tissues (gills and liver) against free radical induced toxicity.
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