Laila M. Fadda1, Nouf M. Al-Rasheed1, Iman H. Hasan1, Hanaa M. Ali2,3*, Nawal M. Al-Rasheed1,4, Musaed Al-Fayez5, Aly M. Ahmed5, Nada Almutlaq1, Nehal Qasem1 and Reem Khalaf1

... liver injury induced by inflammation, oxidative stress in response to APAP toxicity in rats. Serum aminotransferases (ALT and AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total protein, total bilirubin, hepatic glutathione (GSH), nitric oxide (NO), superoxide dismutase (SOD) and lipid peroxides (LP) levels were estimated. Moreover these biochemical parameters were confirmed by histopathological examination using hemotoxylin and eosin (H&...

Iqra Mahmood1, Asif Nadeem1*, Masroor Ellahi Babar2, Muhammad Muddassir Ali1, Maryam Javed1, Aisha Siddiqa1, Tanveer Hussain2 and Muhammad Tariq Pervez2

...>Mastitis (mammary gland inflammation) is one of the most important diseases causing economic losses to dairy farm owners. In order to develop new strategies to prevent mastitis, a detailed understanding of the molecular mechanisms underlying the host immune response to the infectious agents is necessary. Identification of the genes, and their variants, involved in innate immune responses is essential for the understanding of this inflammatory disease and to i...
Hafiz Muhammad Ishaq1, Muhammad Shahzad2, Xiaokang Wu3, Chaofeng Ma4 and Jiru Xu1,*
...lung disease that causes inflammation and narrows the air passages. Present study aimed to characterize the gut microbiota of asthma patients and to investigate the alteration in similarity and diversity of gut microbial composition with comparison of healthy controls. Fecal samples from fifteen patients and five healthy individuals were collected. PCR-DGGE, by using universal primers focusing V3 region of 16S rRNA gene, was performed for characterization of g...
Farhat Ijaz1, Rana Khurram Aftab2*, Samia Jawed3
...tes of low-grade chronic inflammation, which result in increased levels of inflammatory markers such as C-reactive protein (CRP), interleukins 6 (1L-6) and tumor necrosis factor alpha (TNF-α). Relation of TNF-α with obesity induced IR and T2DM is unclear as results obtained from different studies are very controversial.
Objective: This study was designed to compare TNF-α levels and insulin resistance in obese and non-obese ...
Ayesha Noreen1, Dilara A. Bukhari2 and Abdul Rehman1,*
..., inducing angiogenesis, inflammation and cellular transformation in cancer. A better understanding into the mechanism of ROS in cancer progression might be useful for the development of biomarkers and therapeutic strategies. The objective of this review was to summarize the roles of ROS in different stages of cancer, cell invasion, angiogenesis and metastasis.
...
Ashraf M. Mounir, A.N. El shahat* and A.M. Abdul Azeem
...ardiac oxidative stress, inflammation, hyper-lipidemia and increase cardiac marker enzymes. Treatment of rats with GFAE (45 mg/kg/day) prior to injection of ISO provide significant cardio-protective effects evidenced by an obvious reduction in the level of cardiac marker enzymes, inflammatory factors and lipid contents with marked improvement in the cardiac antioxidant status and reduction of lipid peroxidation relative to untreated infarcted group. The...

Tasleem Akhtar, Nadeem Sheikh*

Induction of acute phase in response to tacrolimus induced hepatotoxicity
...acute phase response and inflammation by examining the alterations in the level of acute phase proteins due to the toxic effect of an immunosuppressive drug (tacrolimus). Aqueous suspension of tacrolimus powder (3 mg/ml) was orally given to four experimental groups of wistar rats. Control group was provided with normal drinking water and dissections were done after 6, 12, 24 and 48 h of tacrolimus dose. Densitometric analysis revealed considerable elevated lev...

Shaukat Ali1,*, Sundas Nasreen1, Sobia Safeer1, Saiqa Andleeb1, Mubashir Ejaz1, Saira Bano2, Hafiz Abdullah Shakir3

Medicinal plants as therapeutic agents for cancer treatment
...to treat different human inflammations since ancient time. Many
of anticancer lead bioactive molecules such as vinca alkaloid, vinblastine, vincristine, camptothecin, and taxanes
have been characterized from different medicinal plants and are used as therapeutic agents in worldwide. Technical
strategies based on the natural yield of drug innovation, ethnomedicines and traditional pharmacology is reemerging
to caring good base as str...

 Ihsan Ali1#, Asim Aslam1*, Habib-ur-Rehman2, Beenish Zahid3, Ishtiaq Ahmed1

Effect of fish oil on growth performance and immune response in experimentally infected broiler chicken with avian influenza virus H9N2
...mmune status and subside inflammation. This study was
design to observe the effects of Fish oil on lymphoid organs through
histopathology, growth performance and antibody response in H9N2 challenged
broilers. A total of 80 chicks were divided in to 4 groups A, B, C & D. Group A and
B were challenged with AI virus (H9N2) on 21 day of age, group B and C were
treated with 3% FO while group A and D were treated with cooking o...
Jian Wang1,*, Zhi Liu2, Sheng Xu2, Mei-Fen Hu2, Xiao-Rui Liu1 and Wen-Jie Cai1
...ogical reaction of micro inflammation in the patients, and tightly correlated with the merger of infection. The high concentration of CXCL8 in serum can be quickly filtered out by Hemodialysis in the short term and the transcription level of CXCL8 mRNA in neutrophils also be induced down regulation, and subsequently promote the recovery of injury via the inhibition pathway of micro inflammatory immune. In order to prevent excessive micro ...
Jie Yang
...tibacterial immunity and inflammation. Mammals have four PGRPs (PGLYRP1, PGLYRP2, PGLYRP3 and GLYRP4). They are secreted proteins expressed in different tissues. It is significant to make a study of human PGLYRP1 because neutrophils are a more dominant mechanism in human host defense. Related research results show the functions of human PGLYRP1 in the innate immunity of neutrophils is to conducive to the killing of intracellular and extracellular bacteria. Bac...

Abdul Kabir1, Laiba Uroog2*, Naushad Ahmad3, Fawad Ahmad3, Muhammad Saqib3, Noor Badshah4 and Taj Ali Khan3 

...stitis is multifactorial inflammation of mammary glands in dairy animals, resulting in changes in milk quality, milk production, and economic losses to dairy farmers. It mainly occurs due to non-contagious environmental bacterial species. In Pakistan, it is the major disease of different dairy animals including bovines. However, only a little information is available about bacterial profile of the disease. A cross-sectional study was conducted to find the Eti...
Pin Lyu1, Xiangxian Chen2* andQinlong Liu3*
...howed the best effect in inflammation suppression, skeletal muscle regeneration, control of skeletal muscle fibrosis and muscular tissue re-construction. The skeletal muscular structure and C-reactive protein level could reflect the recovery process after skeletal muscles injury with high sensitivity in groups with the four different rehabilitation methods. 
...

Shaikh Abdul Lateef, Zhou Lin, Wu Jian, Junjie Qian, Jonathan Hartanto Tan and Zheng Shusen*
 

...gression manifests liver inflammation, chronic hepatitis and hepatocellular carcinoma. In this article, we present a comprehensive review characterizing the viral architecture, life cycle, infectivity mechanisms, immune escape strategies, disease epidemiology and preventive measures associated with HBV. The current antiviral therapeutics are not providing adequate protection against HBV. It is mandatory to characterize and devise novel antiviral therapies to c...
Zhijun Zhong1, Rui Tu1, Xichun Wang2, Yi Geng1, Qicheng Xiao1, Yinan Tian1, Bin Wei1, Jiaming Dan1, Ya Wang1 and Guangneng Peng1,*
...anges revealed extensive inflammation and necrosis in the liver, lung, spleen, kidney, testicle, and lymph nodes, among which changes in the spleen were the most serious. Immunohistochemistry results demonstrated the detection of B. canis antigens in the lesions of all examined tissues. Strong positive staining was primarily found in the spleen, liver, and testicle. In conclusion, this study was the first to report the isolation of two B. canis s...
Lin Sun1, Xiaofang Bu2, Jian Wang1*, Xiaorui Liu1 and Zhanyi Kong2
... MP.
...
Saara Ahmad1,*, Iftikhar Ahmed2, Saida Haider3, Zehra Batool4, Laraib Liaquat3, Fatima Ahmed5, Asra Khan1, Tahira Perveen3, Mirza Jawad ul Hasnain6, Saima Khaliq7 and Saad Bilal Ahmed8
...ks showed development of inflammation, necrosis, apoptosis and cirrhosis on histopathological examination of the liver, and had raised plasma TNF-α and AFP-levels. This study shows that damage to liver cells is caused by consumption of commercial feed for chickens and their meat which is considered safe for human consumption.
...

Yuan Xing, Congming Tan, Yan Luo and Wenjun Liu* 

...ibitory effect on airway inflammation in mice and its possible mechanism of action. The mice received varying doses of quercetin from 22-30 days (1, 10 and 50 mg / kg, p.o.) and montelukast (10 mg / kg, p.o.). Intranasal OVA has been instilled on the 21 days. Biochemical parameters, spleen weight, physiological parameters, interleukin (IL-1β and IL-6) parameters and immunoglobin-E (IgE) were calculated at the end of the experimental study. To investigate ...
Muhammad Farhan Qadir1, Xin-Yu Han1, Meng-li Qiao1, Ying Wang1, Ding Zhang1, Yu-hai Bi1,2, Ali Raza Jahejo1,Qian-qian Cheng1 and Wen-xia Tian1,*
...ody which participate in inflammation and immune responses. However, expression levels of prostaglandins-related genes in H9N2 infected chicken’s erythrocytes have not been studied yet. So, the present study was designed to investigate the PG-related genes in erythrocytes of H9N2 infected chickens. In current study, qRT-PCR and Western blot analysis were performed to identify the expression levels of PG-related genes (COX-2, GSTA3, PTGDS, PTGES, PTGER3 a...
Guangyu Wang, Xu Tian, Lintao Liu, Junyang Liu, Bo Zhang and Jingming Dong*
... hyaluronate on synovial inflammation in a patients with KOA. A total of 180 patients with knee osteoarthritis who were treated in our hospital were enrolled as the study subjects who were divided into study group and reference group, each with 90 cases. The reference group received sodium hyaluronate injection treatment, while the study group was given SJHXT combined with sodium hyaluronate. The therapeutic effects were compared between the two groups. Compar...
Ou-Mei Hao1*, Xue-Feng Wang1, Zhi-Jun Yue1, Chun-Hong Nan1,Yan Yu1,Tong Zhang2,Yu-Feng Liu3 and Xue Zhao1
... factors associated with inflammation after Mycoplasma pneumoniae pneumonia (MPP) infection and compare the therapeutic effects of Qing Zhi Zhi Ke formula (QZZKF), QZZKF combined with azithromycin (AZM) and AZM on experimental mice. Fifty female BALB/c mice were randomly divided into five groups: control, model, AZM (0.01 g/kg/day), QZZKF (10.16 g/kg/day), AZM (0.01 g/kg/day) combined with QZZKF (10.16 g/kg/day). QZZKF and AZM were administered by oral ...
Muhammad Farhan Qadir1, Xin-Yu Han1, Meng-li Qiao1, Qian-qian Cheng1
Raza Ali Mangi1, Ali Raza Jahejo1, Afrasyab Khan1, Yu-hai Bi1,2 and Wen-xia Tian1*
...ody which participate in inflammation and immune responses. Influenza viruses interact with the host cells at cell surface, leading to cell death in human and animals through apoptosis. Current study was designed to investigate the expression levels of apoptosis-related genes in the H9N2 infected chicken erythrocytes. qRT-PCR and Western blot techniques were performed to determine the expression levels of apoptosis-related genes including Bax, Bcl-2 BAG-1, BAG...
Zhiyuan Sun1, 3, Xuhui Zhang2,*, Xian Li3, Yanping Huang3, Shiyan Sui3, Weifeng Liu3, Guochao Ni3, Xiaozhou Xu1, Jianbo Yang1, Xue Lian1 and Hui Jia1
...accharide (LPS) -induced inflammation via the crosstalk. Pigs were administered LPS injection with or without continuous adrenocorticotropine hormone (ACTH) pretreatment. Twenty-four 30-day-old Duroc × Landrace × Large White crossbred piglets (12 ± 0.5 kg) were randomly assigned to 4 treatments: control, LPS, ACTH, and ACTH+LPS groups. Each group consisted of 6 male piglets. All ACTH pigs and ACTH+LPS pigs were injected intramuscularly with ...
Roheela Yasmeen1*, Laiba Asif1 and Samia Djeffal2
... as dysmenorrhea, ocular inflammation, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and actinic keratosis etc. Although, it is good for livestock, its impact on the vulture population has been very deleterious. The present review discusses the chemical structure, uses, and the mechanism of the action of diclofenac and its negative impacts on vulture populations along with less harmful alternatives such as meloxicam, and controlling measures to...
Syed Shahid Imran Bukhari1*, Nusrat Jahan2, Muhammad Khalil Ahmed Khan3, Mariam Zaheer1, Sabir Javed1
...showed vacuolization and inflammation of cells whereas, group 3 showed improvements with normal islets with surrounding acini and lobular structure of hepatocytes. 
 
Novelty Statement | This study reports that Aloe vera which is commonly grown in houses has very strong antidiabetic and antihyperlipidemic properties.
...

Ayesha Muzamil, Hafiz Muhammad Tahir, Shaukat Ali, Iram Liaqat, Aamir Ali, Muhammad Summer

...ncontrolled or excessive inflammation is destructive for normal homeostatic processes of body. Most of the modern human diseases such as asthma, allergy, autoimmune diseases, hepatitis, coeliac disease, inflammatory bowel disease and glomerulonephritis are linked directly or indirectly to different inflammatory processes. Conventionally, different steroidal and non steroidal drugs i.e., antibiotics are used to treat inflammatory disorders. Theses synthetic dru...
Ardi Prasetio1*, Christina Maria Sri Lestari2, Sutaryo Sutaryo2, Manar Fayiz Mousa Atoum3,4Muhammad Zahoor5, Asma Nisar6 and Muhannad Illayan Massadeh7
...LF may cause subclinical inflammation by blood parameter detection. Thus, this study investigated the BSLF substitution effect on rabbit blood traits. This study was performed using 28 wk old weaned male New Zealand White rabbits (1300 g ± 130 g) that were randomly divided into control group (T0) and treatment group (T1, T2, T3), which respectively substituted 0 %, 10 %, 20 %, and 30 % SBM with BSFL. Blood samples were collected from the right ear margi...

Mohammad Hussain Haidary1, Rozanaliza Radzi1*, Muhammad Waseem Aslam1, Seng Fong Lau1, Farina Mustaffa Kamal2, Ahmad Rasul Radzali1 

...ral examination with the inflammation at the caudal oral cavity and lateral to the palatoglossal folds. Descriptive statistics were derived from the retrospective data using simple percentages. Fifty-seven cats were analyzed up to the final treatment with known survival status. The majority affected cats age between 3-6 years old (24/57) and male (41/57). Most affected cats came from indoor multicats households. The two most common clinical signs were halitosi...

Muhammad Abdullah1, Sana Zahoor1*, Akhtar Ali2 and Masroor Ellahi Babar3

...a; polymorphism leads to inflammation and provoke asthma which lead to morbidity and mortality in the population. The objective of the study was to look into single nucleotide polymorphism in upstream region of -238TNF-α and -308 by ARMS PCR technique in asthmatic and control group. It was a prospective study constituting 17 clinical diagnosed asthmatic patients (Diseased) and 19 non-asthmatic patients (Control). The female was 6 (31.6%) and males were 1...

Noura El-Shahat Attia1*, Abd El-Khalek Ramadan El-Sheikh1, Mohamed Omia Siam2 

... hair, crust, scales and inflammation of skin “dermatitis”. All dogs were subjected to clinical and laboratory examinations followed by special dermatological examination. Skin scrapings were examined under light microscope for the detection of fungal spores or mites. Blood samples were taken for hematological analysis, along with taking serum samples for biochemical analysis. Rectal temperature, heart, and respiration rates were not significantly ...

Hafiz Adnan Ahmad1,2*, Muhammad Aslam2, Salman Gul2, Tariq Mehmood2 and Munawar Ali Munawar2

...4b displayed better anti-inflammation potential than standard drugs celecoxib and indomethacin. While the anti-inflammation profile of compounds 4h, 4e and 4f during in vivo screening was also comparable to celecoxib and indomethacin. The structure-activity relationship (SAR) was also discussed with the reference of substituent nature. Present results showed that newly synthesized hybrids have significant anti-inflammatory p...

Heba El-Zahar*, Zeinab Abd El-Rahman, Abbas El-Naggar 

...ic gastrointestinal inflammation. Due to the continuous rise in incidence, simple and cost-effective methods of diagnostic and clinical assessment are urgently required. The goal of this study was to look at the hematobiochemical alterations in association with the evaluation of C-reactive proteins (CRP), haptoglobin and fecal calprotectin concentration as prognostic markers in dogs with IBD. After a detailed clinical, laboratory and ultrasonographic exam...

Ji Xu, Zhonghua Liu, Zhenhai Cui and Wenhai Zhao*

...eta;-induced chondrocyte inflammation and apoptosis by up-regulating the expression of miR-99a.

...

Qiong Xiang1, Jing-Jing Li1, Qian Zhang1,3, Rong-Bo Tian1 and Xian-Hui Li1,2*

...jecting Carrageenan, the inflammation-induced reagent into the mouse left-hind paw(Ipsilateral-side). Compared with the SSTR2 in normal right -hind paw(contralateral-side) DRGs. The variation of SSTR2 protein expression is fast, because about 15 min after injection the significant up-regulated expression of the SSTR2 proteins are found in inflammatory DRG neurons compared to that of in control DRG neurons. The process is also time-dependent, because no differe...

Barirah Rehman Talpur1, Zaheer Ahmed Nizamani1*, Imdad Hussain Leghari2, Mansoor Tariq1, Aisha Rehman3, Shahnawaz Kumbhar1 

...y findings included mild inflammation and discoloration of liver along with nephritis. While in broilers, toxic lesions were observed on mucus membranes of duodenum and proventriculus along with nephritis. Histological lesions observed in livers of both rabbits and broilers included dilation of central vein and sinusoids and fatty degeneration of hepatocytes. Kidney tissues of both rabbits and broilers revealed marked shrinkage of glomeruli with widened bowman...

Yahia A. Amin1*, Alaa Eldin Z. Mahmoud2, Mohamed Sabry Aref3, Abd El-Latif Shaker Seddek4, Waleed Younis5 

... the severity of uterine inflammation and the longest postpartum period of pregnancy. Various types of bacteria are responsible for endometritis, such as Staphylococcus, Streptococcus, E. coli, and Klebsiella. Cefoperazone is the most sensitive antibiotic for the treatment of complicated cases of postpartum endometritis caused by mixed infections and high virulence bacteria.

Keywords | Endometritis, Bacterial infection, Cefoperazone treatment, Dairy co...

Peyman Mohammadzadeh1*, Aida Rasuli2, Bahman Noroozi Gorgani2, Sajjad Mohammadi3

... Choroid blindness, Neuroinflammation, Neuro-ocular toxoplasmosis, Red Kangaroo, Traumatic Brain Injury, Necropsy, Histopathology
...

Dhiya Altememy1, Mohammad Darvishi2*, Samira Shokri3, Saber Abbaszadeh4 

...wound microbial load and inflammation and ultimately repair wounds in diabetic rats due to antimicrobial and anti-inflammatory activities. They can therefore be used as an effective remedy for healing wound infections in diabetics.

Keywords | Nanoparticle, Herbal plants, Diabetes, Staphylococcus aureus, Treatment 

...

Marwa S. Khattab1*, Ahmed H. Osman1, Huda O. AbuBakr2, Rehab A. Azouz3, Asmaa A. Azouz4, Heba S. Farag5 

...inophilic dermatitis and inflammation of subcutaneous hypodermis (panniculitis) whereas, in the skin with high ivermectin residue, there was mild multifocal epithelial hyperplasia with mild perivascular mononuclear cells infiltration. Conclusion: Different levels of ivermectin residue were detected in bovine skin samples collected from slaughterhouses in Egypt however the degree of damage caused by ectoparasites exceeds the damage caused by ivermectin.

Farah Abid1,2, Mohammad Saleem1,3*, Tahir Maqbool4, Tania Ahmed Shakoori5, Faheem Hadi4, Tahir Muhammad4, Saira Aftab4, Yasir Hassan7 and Shabana Akhtar4,6*
...act (E-AM) in process of inflammation and also in arthritis by using animal model of rat. Thirty-six healthy wister rats were chosen for in vivo experiments and divided into six groups. Arthritis was induced in rats using Complete Freund’s Adjuvant (CFA) and treated with different concentrations of E-AM (250, 500 or 750 mg/kg), and with standard treatment, piroxicam (10 mg/kg). Antioxidant assays (superoxide dismutase and catalase) and histopathological ...

Saima Rubab1,3*, Ghazala H Rizwani2, Arjumand Iqbal Durrani3, Iram Liaqat4*, Urooj Zafar5, Mahjabeen6, Farah Batool7, Noor-E- Seher3, Naveera Younas3 and Ayesha Sadiqa8

...cking - biting response, inflammation of hind paw and writhing effect. The results showed that different pharmacological activities were due to the presences of various phytochemicals like tannins, resin and flavonoids, observed maximally in ethanolic extract with minor quantity of alkaloids and glycosides. Fourier transform infrared spectroscopy (FTIR) of dried roots, stems, leaves and seeds provided a conclusive support to the above results. Anti-inflammator...

Samiya Rehman*, Eman Mustafa, Ali Ahmad Faiz, Maheen Kanwal, Farkhanda Yasmin and Arooj Fatima

...n of myelin sheath, neuroinflammation resulted in reduced memory, decision making and thinking power. The adverse effects of drug addiction can be reversed to greater extent through usage of anti-inflammatory drugs, exercise and deactivation of microglial pathways. Plants are proved to be promising source of recovering drug addiction side effects. This article also focuses on psychological and emotional regulations, caused by drug addiction involve depression,...

S. Feroza 1, A. G. Arijo1†, F. M. Bilqees2* and M. S. Phulan1

...pots on intestinal wall, inflammation and necrotic patches with consolidation of intestinal contents were generally observed. Infected liver showed dark red coloration. Severe congestion, chronic pneumonia, exuded in one lobe of the lung were seen, whereas, necrosis and atrophy in infected heart were notable observations.

...

Pakistan Journal of Nematology

December

Pakistan Journal of Nematology, Vol. 32, Iss. 2, Pages 123-240

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