Muhammad Ibrahim, Jawaria Ali Khan, Muhammad Sarwar Khan, Wasim Shehzad, Muhammad Avais, Ali Husnain, Naimatullah Khan, Muhammad Kamran Ameen and Abdullah Iqbal

... were the most efficient drugs as 66% cows suffering from subclinical mastitis were recovered by treatment of each of them. Cows suffering from subclinical mastitis showed a 50 % recovery percentage when treated with lemon for five days and 33 percent cows recovered from subclinical mastitis when treated with Black Pepper for five days. Udder health status and milk quality can be enhanced with use of Garlic and Vitamin E + Se combination in cows.

...

Shagufta Jabeen1, Muhammad Saqlain Raja1, Sadia Saeed1, Muhammad Mobeen Zafar1, Rizwana Abdul Ghani1, Abid Mahmood1, Muhammad Fiaz2, Pakeeza Arzoo Shiaq1, Shahid Mahmood Baig3, S.M. Saqlan Naqvi1 and Ghazala Kaukab Raja1

... including other illicit drugs is a chronic, relapsing multifactorial disorder of brain and, if left untreated, major medical, social, and economic problems arise. Drug addiction is among major health issues faced by the World including Pakistan with an alarming annual increase in heroin addicts. The study was designed to identify the socio-demographic risk factors contributing to increasing susceptibility to heroin addiction in Pakistani populations. In this ...

KM Fakhrul-Islam, Mohammad Shah Jalal, Sonnet Poddr, Md Nurul Quader, Md Sahidur-Rahman, Avijit Dutta and Shuvo Mazumder

...ering clinical signs and drugs used for treatment during 13 January to 15 March 2015. A total of 131 cattle was investigated and 16.8% cattle cattle were recorded as FMD. The proportionate prevalence of FMD in different study areas were 4.5-18.2%. The occurrence of FMD was higher in February (23.3%) than in January (13.5%) and March (18.5%). Younger cattle were more commonly affected (59.1%) than older ones. Almost 96% of the female cattle were FMD positive. C...

Tuli Dey, Sonnet Poddar and Mukti Barua

...ihistaminic and hormonal drugs were given. This case as well as the condition of the animal were followed up and gave the result of successful recovery without any complication.

...
Salman Khalid1,*, Abdul Rehman2, Mohammad Yasin Amir1, Abdul Rehman1, Imran Sarfaraz1 and Muhammad Asif1
...nd efficacy of different drugs on controlling tick’s infestation in commercial layer, a double blind randomized controlled trial was conducted. For therapeutic trials, the 80 birds (n= 60 infested with ticks, n= 20 healthy birds) were selected and divided into four groups (A, B, C and D), each comprising of 20 birds. Group A and B were treated with Ivermectin @ 0.2mg/Kg orally for two days and Fipronil (Spray at once), respectively. Group C was kept as p...

D. C. Khatua, B. Mondal and G. Saha

Bioassay of some agricultural chemicals, human drugs and disinfectants on Phytophthora melonis Katsura causing fruit and vine rot of pointed gourd
...ctants and antiprotozoal drugs were tested on Phtophthora melonis Katsura causing fruit and vine rot of pointed gourd in aqueous environment. Antifungal antibiotics viz. validamycin, kasugamycin, griseofulvin, fluconazole and ketoconazole did not have any pronounced effect on mycelial growth, sporangia formation and its germination. None of the eight antibiotics used in this study prevented mycelial growth. No sporangia formation was recorded in five antibioti...

Jawad Anwar* and Zafar Iqbal 

...ial source of antibiotic drugs as it showed a wide range of bioactivity against both phyto and human pathogenic bacteria.  

...

Sanjukta Chakrabarti1, Colin J. Barrow2, Rupinder K. Kanwar3, Venkata Ramana1*, Rakesh N. Veedu4,5 and Jagat R. Kanwar3* 

...nesis. Several anti-VEGF drugs have been developed over the last two decades and some are still at different development stages of pre-clinical and clinical trials. In this study, we explored the anti-angiogenic properties of three anti-VEGF molecules such as two fusion proteins, VEGF TrapR1R2 and VEGFR1(D1-D3)-Fc, and one DNA aptamer, RNV66, in an in vivo model of human A549 lung cancer. VEGF TrapR1R2 is a commercial anti-angiogenic fusion protein. Our earlie...
Tahira Perveen1,*, Shaista Emad1, Saara Ahmad2, Zehra Batool1, Sarwat Yousuf1, Sheeza Sheikh1, Sara Qadeer1 and Saida Haider1
...epressants are effective drugs for the treatment of psychiatric disorders. Along with the effectiveness these drugs are also associated with some side effects. Since ancient times herbs are used as medicinal purposes. One such herb is Fennel (Foeniculum vulgare). Fennel has many efficacious uses. It is a common herb and spice. It is used in many culinary purposes and also it has therapeutic purposes. In the present st...
Sana Imran1*, Sarwat Jahan2 and Mohammad Sair3
...ic patients taking these drugs.In this randomized and comparative study, psoriasis severity was checked by Psoriasis Area Severity Index (PASI). At day 90 Calcipotriol treated group B patients showed more improvement in mean PASI score as compared to Betamethasone valerate treated group A patients. In PASI score, Calcipotriol shows 71.61% betterment whereas Betamethasone vale rate shows 63.2% betterment in mild psoriatic patients. In PASI score, Calcipotriol s...
Faiza Hassan1, Mubshara Saadia1,*, Muhammad Sher1, Mian Anjum Murtaza2, Muhammad Arshad3,Asam Riaz4 and Mahmood Ahmad Khan5
...of diabetes by synthetic drugs has been found cost effective with severe side effects as well. Herbal remedies are gaining popularity. Black cumin and garlic are found effective against hypoglycemia, hyperlipidemia, and hypercholesterolemia. Present study was designed to evaluate the relative antidiabetic potential of garlic aqueous (AGE) and petroleum ether (EGE) extracts compared to black cumin (Nigella sativa oil; NSO) and insulin. Alloxan induced di...
Mahboob Ali1, Muhammad Avais1, Riaz Hussain2, Kashif Prince1,*, Muhammad Ijaz1, Mamoona Chaudhry 3, Sehrish Firyal4, Amjad Islam Aqib1, Naimat Ullah Khan5 , Mian Saeed Sarwar5, Hazrat Ali5, Shahid Hussain Farooqi1, Ikramul Haq1 and Muhammad Sajid Hasni3
... therapeutic response to drugs. Two different ecological zones, Cholistan (n=185) and Suleiman Range (n=177) of Pakistan having major population of camel were screened for subclinical mastitis using California mastitis test using convenient sampling technique. Biochemical examination was performed to isolate S. aureus that further were tested Penicillin, Glycopeptide, and Cephalosporin classes of antibiotics for confirmation of MDR isolates using disk d...

Mian Sajjad Ahmad1, Somia Iqtadar1, Sami Ullah Mumtaz1*, Zafar Niaz1, Iqra Waheed2 and Sajid Abaidullah

... physical exercise & drugs should be taken to control obesity. 

...
Musrrat Fatima, Muhammad Saad Khan, Hamid Rashid, Asim Mehmood, Sumaira Kanwal, Muhammad Asif Rasheed and Farrukh Jamil*
...ere is a need to develop drugs against ZIKV. Here we uses pharmacoinformatics techniques to identify potential inhibitors against ZIKV protease NS2B-NS3, which has a well-known role in the viral replication. By using three dimensional structure of the NS2B-NS3, an allosteric site has been identified in the protein. Moreover, the identified site is used for structure-based virtual screening. After screening 100,000 compounds, 14 compounds are selected, which fu...
Muhammad Shahid Saeed1, Adeela Shahid2, Samia Jawed3, Muhammad Akram4, Irshad Hussain Qureshi5 
... factors. There are many drugs available for asthma and magnesium sulphate is given intravenously as an important adjunct therapy during the acute severe attack of asthma
Objective: This study was panned to determine the effect of intravenous MgSO4 on pulmonary function test in acute severe attack of asthma.
Methodology: A double blind placebo control study was conduced on about 132 asthmatics, which were aged b...
Sahar Naz1, Farhan Rasheed2, Muhammad Saeed3*, Shagufta Iram4 and Ambereen Anwar Imran5
Zartasha Anjum1*, Rakhshindah Bajwa2 and Munazza Hassan3
...ct | Statins are the drugs that target 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoAR). Several studies have reported the anti-tumoral properties of statins by exhibiting anti-proliferative properties in HMG-CoAR positive breast carcinomas. Increased efficacy has also been observed when these were used as combination therapy along with tamoxifen in estrogen receptor (ER) and HMG-COAR positive breast carcinomas. However, in our local population, ...
Ayesha Noreen1, Dilara A. Bukhari2 and Abdul Rehman1,*
...ke, tobacco, xenobiotic, drugs, medical materials, radiations, pesticides, industrial solvents and ozone. The processes running in the cell membranes, peroxisomes, mitochondria and endoplasmic reticulum also generate ROS. ROS can be activated by numerous external factors, and play an important role in cancer growth and metastasis. ROS and tumor cell interaction could activate the signalling pathways, promoting cell proliferation, invasion, inducing angiogenesi...

 

Syed Aun Muhammad1, Muhammad Soaib Said2, Shams Ur Rehman2, Muhammad Dawood2, Muneer Ahmed Qazi3 and Nighat Fatima2,*
...d for discovery of novel drugs with selective potential. In this study, we illuminate the binding mode of pimarane diterpenes (diaporthein A and diaporthein B) to the NMD-1 by molecular docking. A computational ligand-target docking approach was used to analyze structural complexes of enzyme target with diaportheins. Auto Grid model showed the most energetically favorable binding mode of natural compounds to beta-lactamase. Docked energies for diaporthein A an...
Rida Zainab1, Sana Elahi1, Afshan Kaleem2,*, Daniel C. Hoessli3, Mehwish Iqtedar2, Roheena Abdullah2, Faiza Saleem2, Shanza Khan1, Anusha Ijaz1, Shagufta Naz2 and Abdul R. Shakoori4,5,*
...o develop more efficient drugs. One of the computational methods becoming increasingly popular to develop new drugs is relying on Pharmacophores. This method was utilized to develop pharmacophore models of Akt2 inhibitors and β2-Adrenoceptor agonists. A pharmacophore model is proposed, using fourteen second generation and one first generation antipsychotic drugs for Schizophrenia that...
Muhammad Khan
...ing new uses of existing drugs) has offered a novel strategy for discovering new anticancer drugs from non-cancer drugs. Drug repurposing has attracted the attention of scientific community involved in anticancer drug discovery because it is cost effective and less time consuming compared to the conventional drug discovery strategy involving de novo identification, characterization ...
Amjad Islam Aqib1,*, Shagufta Nighat2, Rais Ahmed3, Saba Sana3, Muhammad Ameen Jamal4, Muhammad Fakhar-e-Alam Kulyar2 , Naimat Ullah Khan5, Mian Saeed Sarwar5, Muhammad Asif Hussain5, Asadullah5, Attaur Rahman5 and Sadeeq ur Rahman5,*
...ns, macrolides and other drugs showed that 50% of CPS and 30% of CNS were found multi-drug resistant-exhibiting resistance against more than two or more than two classes of drugs. None of the CPS while 20 % from CNS isolates were 100% susceptible to all kinds of drugs tested. Finally, age, grazing system, use of beta-lactam antibiotics, parity, and poor hygiene were potential risk factors....

Shaukat Ali1,*, Sundas Nasreen1, Sobia Safeer1, Saiqa Andleeb1, Mubashir Ejaz1, Saira Bano2, Hafiz Abdullah Shakir3

Medicinal plants as therapeutic agents for cancer treatment
...otent natural sources of drugs to treat different human inflammations since ancient time. Many
of anticancer lead bioactive molecules such as vinca alkaloid, vinblastine, vincristine, camptothecin, and taxanes
have been characterized from different medicinal plants and are used as therapeutic agents in worldwide. Technical
strategies based on the natural yield of drug innovation, ethnomedicines and traditional pharmacology is reemerging
Muhammad Hidayat Rasool1,*, Muhammad Zaheer1, Muhammad Farooque Hassan2, Muhammad Shafique1 and Muhammad Usman Qamar1
...s were resistant towards drugs such as cephalosporin, ceftazidime but majority of them were sensitive to polymyxins, tazocin and fusidic acid. Proper screening of MBLs producing GNRs should be done from clinical specimens along with antimicrobial susceptibility testing for developing an effective treatment strategy and thus better control of infections caused by these bugs in future.
...

Sabi-Ur-Rehman1, Anwar Khalid2, Qazi Najam Us Saqib3, Farooq Ahmad1, Shaheed-Ur-Rehman4, Neelam Zaman3, Ayeza Mehmood5 and Abdul Samad6*  

...r to overcome antibiotic drugs resistance, plants provide source for discovery of new antimicrobial drugs. This study was carried out, include in-vitro antibacterial and antifungal screening of aqueous methanolic extracts as well as crude saponins isolated from leaves and roots of Sarcococca saligna, using disc diffusion method. The tested bacterial strains include, B. subtilis, E. coli, S. aureus, P. fluorescens and fungal ...
Wali Khan1,*, Mudassar Iqbal2 and Israr Khan2
...s. Therefore both of the drugs used are equally contributed in the controlling of intestinal parasitic diseases in children.
...
Qi Ren, Shufeng Sun, Chen Niu, Yuhong Li, Yingzhi Chong, Biao Li, Guoying Zheng and Fumin Feng*

 

...tance. Anti-tuberculosis drugs induced hepatotoxicity in HL-7702 cells was investigated. Dehydrogenase activity was detected by a lactate dehydrogenase assay kit; superoxide dismutase (SOD) activity and malonaldehyde (MDA) concentration were detected by a total superoxide dismutase test kit and a malondialdehyde test kit. Genomic DNA and RNA were extracted from cells; Methylation was inhibited by treating HL7702 cells with 5-aza-2’-deoxycytidine (AZA), a...
Barkat Ali1,2, Wasim Sajjad1,2,3, Imran Khan1, Muhammad Rafiq1, Sahib Zada1, Aamer Ali Shah1 and Fariha Hasan1,*
...ing of new antimicrobial drugs is always needed to solve the problem of continue resistance emerging among microorganisms against antibiotics already in use. Microorganisms from unusual environments, such as reported from the surface and inside of rocks are a repository of certain metabolites that might be able to solve the problem of increasing resistance against antibiotics. The present study was designed to isolate endolithic and epilithic bacterial strains...
Tanveer Ahmad1, Tariq Mehmood1, Muhammad Shahid1, Adnan Ahmad1,2, Muhammad Asim Raza Basra1, Muhammad Zia-ur-Rehman3* and Munawar Ali Munawar1
...xcellent addition in the drugs used to suppress the higher level of blood glucose level in diabetes mellitus.
...
Hong-mei Gao, Wen-long Su, Gui-bin Tao, Han-yang Li, Wen-zheng Cao and Zhi-dong Qiu*
...w (BM).Most chemotherapy drugs are toxic to cancer cells and normal healthy hematopoietic cells. Hemoglobin and red blood cell levels drop in cancer patients treated with chemotherapy. Geniposide can reduce the adverse radiation damage of bloosd tissue after high dose irradiation.We found that geniposide can recovery the red blood count after chemotherapy medications (5-Fluorouracil, 5-FU) treatment mice. The mechanism of action of genistein on erythrocyte pro...

Ihsanullah Kakr1, Sarwar Khan2, Khalid Khan3* and Sajjad Ahmed

...lude additional costs of drugs, veterinarian fee, preventive medicine and quarantine. Moreover, the present study demonstrates that the respondents above the age of 50 years were more experienced in disease diagnosis and use of traditional veterinary practices. 

...
Mohammad Ejaz1, Salma Javed2, Muhammad Hamza1, Sadia Tabassum2, Muhammad Abubakar3, Irfan Ullah4*
...ch sources for the novel drugs. Endophytes are the rich source of these bioactive molecules having a wide range of applications as compared to the original products. Fungal endophytes are the most commonly used endophytes for the isolation of various different types of bioactive molecules. These bioactive molecules can be used as antimicrobial, antibacterial and anticancer agents. Fungal endophytes like Taxomyces andreanae isolated from Yew plant have t...
Yuhong Li1, Dongxue Wu1, Xue Wang1, Mi Zhang1, Hanyu Zhu1, Zhe Shi1 and Fumin Feng1,2*
...ced by anti-tuberculosis drugs in mice. A total of 168 Kunming mice were randomly divided into four experimental groups and one baseline group. The drug groups were orally administered with isoniazid (H), rifampicin (R), pyrazinamide (Z), and combination of these three drugs (HRZ) at 3, 5, 7, 10, and 15 days, respectively. Liver tissue pathologies and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activi...
Sana Khan1, Raheela Taj1, Noor Rehman2, Asad Ullah3, Imad Khan3 and Sadeeq ur Rahman3,*
...sistant to commonly used drugs, and hence appropriate usage of antibiotics must be ensured to avoid further dissemination.
...
Muhammad Anwarullah1*, Aneela Zameer Durrani1, Muhammad Ijaz1Aftab Ahmad Anjum2, Ghulam Mustafa3, Muhammad Husnain1 and Muhammad Usman1
...e economically important drugs in treatment of Johne’s disease. 
...
Neelam Pery*, Nayab Batool Rizvi, Muhammad Imtiaz Shafiq
...modifying anti-rheumatic drugs over the drug platform has been taken over by a number of biologics including TNFα inhibitors, IL-1 inhibitors, IL-6 inhibitors, and co-stimulatory signal inhibitors with better efficacy and safety profile. However, certain factors such as lack of universal response, the need for prolonged therapy, ...

Anurag Sharma*, Naresh Kumar, Geetanjali Singh and Anika Sharma 

...e commercially available drugs pose health threats and prove detrimental to both human and animal health. The traditional use of herbal preparations suggests that they are safe and effective, however, scientific validation is still required for many of them especially for animal use. The phyto-pharmacological research on these two natural products show a ray of hope for the discovery of new active compounds with a novel structure that has potential to serve as...

Olotu Titilayo Mabel*, Adeosun Idowu Jesulayomi, Kaka Mary Oluwatosin and Oladipo Elijah Kolawole 

...sensitivity to antiviral drugs was analyzed using the Stanford University HIV Drug Resistance Database. Our results revealed that Kenyan strain (SN-042062), Ugandan strain (DR138-13), Sudanese strain (G-01035) and Nigerian strain (NGA-INF-2016-618) have similar branch length. The susceptibility percentage for each antiviral drug ranged from 82.35% (Tenofovir) to 64.70% (Rilpivirine) while and resistance percentage ranged from 35.29% (Rilpivirine) to 23.52% (Ne...

Syeda Farzana Bibi* and Siraj-ud-Din

Fluorescence Analysis, Extractive Values and Cytotoxic Screening of Crataeva adansonii DC Leaf and Bark through Brine Shrimp Larvae Assay
...adulterated or exhausted drugs. It lays down parameters for authentication and standardization of drugs. The cytotoxic study helps in the evaluation of a drug for its toxicity, which is determined by the prevention of growth and replication. Such drugs can be used to treat cancer, multiple sclerosis and rheumatoid arthritis. During the present study ethanolic extracts of leaf and bark part...

Sarhad Journal of Agriculture

September

Vol. 36, Iss. 3, Pages 734-1009

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