Abdul Wajid Khalil and Zafar Iqbal
...ious ailments, including asthma, cough and jaundice. The aim of the study was to determine and compare the proximate, mineral, amino acid compositions of the aerial parts and roots of B. procumbens. The result of carbohydrate (75.56±0.046%) of aerial parts was found higher as compared to the roots (31.22±0.05%) while protein (37.46±0.02%) and organic matter (21.25±0.03%) was recorded higher in roots than the aerial parts of B. procu...
Gut Microbe Analysis between Asthma Patients and Healthy Volunteers in Shaanxi Province, Xian, China
Hafiz Muhammad Ishaq1, Muhammad Shahzad2, Xiaokang Wu3, Chaofeng Ma4 and Jiru Xu1,*
...ze the gut microbiota of asthma patients and to investigate the alteration in similarity and diversity of gut microbial composition with comparison of healthy controls. Fecal samples from fifteen patients and five healthy individuals were collected. PCR-DGGE, by using universal primers focusing V3 region of 16S rRNA gene, was performed for characterization of gut microbial composition. Sequencing of most dominant excised gel bands was done. Real-time PCR was p...
Muhammad Shahid Saeed1, Adeela Shahid2, Samia Jawed3, Muhammad Akram4, Irshad Hussain Qureshi5
...many drugs available for asthma and magnesium sulphate is given intravenously as an important adjunct therapy during the acute severe attack of asthma
Objective: This study was panned to determine the effect of intravenous MgSO4 on pulmonary function test in acute severe attack of asthma.
Methodology: A double blind placebo control study was...
Abid Hussain1,2, Farida Ahmed3, Shyamali C. Dharmage4, Shafiq ur Rehman1, Muhammad Shahbaz Aslam5 and Zaigham Abbas1,*
...clinical conditions like asthma and allergic rhinitis. Present study was conducted to investigate the prevalence of food and aero-allergen sensitization patterns. This retrospective study was designed to study allergy patients attending Allergy Centre, National Institute of Health, Islamabad. All enrolled patients were screened for set of allergens using skin prick test (SPT). Based on results of SPT, out of total 50550 allergen sensitized patients, 89.28% had...
Muhammad Naeem Khan* and Asad Jan
... different ailments like asthma, cold, influenza, head ach, liver and digestive problems and healing of wounds. The aim of the study was to explore phytochemical constituents of methanolic crude extract (MCE) and various solvent fractions and in-vitro antimicrobial activities of whole plant of D. botrys. Qualitative phytochemical screening of MCE and solvent fractions of D. botrys showed the presence of alkaloids, phenols, flavonoids, saponins, tannins and ste...
Yuan Xing, Congming Tan, Yan Luo and Wenjun Liu*
...educed IgE levels in the asthma mice serum. Inflammatory cells in the mice BALF are significantly reduced in a dose-dependent manner through quercetin. Quercetin (P<0.05) significantly reduced the level of TNF-α, IL-1β, IL-4 and IL-5 cytokines and increased the level of IFN-π in allergic asthma mice caused by OVA. In contrast, there was no significant effect in the body weight of mice treated with quercetin....
Bingjie Zhou1, Hitesh Bhagavanbhai Mangukiya1, Siva Bharath Merugu1, Fakhar-un-Nisa Yunus1, Yuchen Fan1, Zhenghua Wu1,* and Dawei Li1,2,*
...nvolved in diseases like asthma and inflammatory bowel disease. Studies on the role of AGR2 in tumor micro-environment can help potential therapeutic development. Here, we report the generation of a fluorescent functional AGR2 fusion protein as a powerful visual tracking tool to trace the external function of AGR2. This bioactive and auto-fluorescent his-tag recombinant AGR2-DsRed (hAD) protein was constructed by linking human AGR2 C-terminus with the red fluo...
Ayesha Muzamil, Hafiz Muhammad Tahir, Shaukat Ali, Iram Liaqat, Aamir Ali, Muhammad Summer
...n human diseases such as asthma, allergy, autoimmune diseases, hepatitis, coeliac disease, inflammatory bowel disease and glomerulonephritis are linked directly or indirectly to different inflammatory processes. Conventionally, different steroidal and non steroidal drugs i.e., antibiotics are used to treat inflammatory disorders. Theses synthetic drugs have many side effects on the health such as gastrointestinal problems, stomach ulcers, dizziness, liver or k...
Muhammad Abdullah1, Sana Zahoor1*, Akhtar Ali2 and Masroor Ellahi Babar3
...inflammation and provoke asthma which lead to morbidity and mortality in the population. The objective of the study was to look into single nucleotide polymorphism in upstream region of -238TNF-α and -308 by ARMS PCR technique in asthmatic and control group. It was a prospective study constituting 17 clinical diagnosed asthmatic patients (Diseased) and 19 non-
Nan Jiang, Tong Liu, Jimin Liu and Guobin Tang*
...e treatment of bronchial asthma, and to explore the mechanism of action. In this study, 180 patients who had been diagnosed and treated for bronchial asthma in our hospital were enrolled as research objects. They were divided into experimental group accepting inhalation of low-dose budesonide powder combined with pulmonary rehabilitation and control group accepting conventional drug therapy. The therapeutic effects of the tw...
Fengbin Jin1, Xin Liu2 and Yanqiu Yue3*
...a low-dose on the severe asthma. A total of 114 patients with severe asthma of hospital were selected between December 2017 and February 2020 as the subjects of this study and divided into the observation group and the control group randomly. Patients in the control group received the regular treatment, while those in the observation group received the treatment by low-dose epinephrine, and the efficacy of these two methods ...
Xiaoying Liang1,2, Xiaofang Jiang3, Honglin Jia1, Ru Zhang1, Li Gao4* and Qing Yang5*
...ed model of experimental asthma. The number of T cell subsets was detected by flow cytometry, the protein expression was detected by enzyme-linked immunosorbent assay, and the gene expression was detected by real-time polymerase chain reaction. In addition, in vitro experiments with Jurkat cells were used to verify the effect of methylase inhibitor 5-Aza-2’-deoxycytidine on the expression of cytokines and genes in the T cells. The expression of Th2 cells...
Farooq Jan1*, Abdur Rauf1, Ikramullah Khan1, Muhammad Yasin2, Muhammad Qayash3, Hazrat Wali1, Muhammad Luqman1, Fayaz Asad4 and Muhammad Khalid5
...different allergies like asthma, rhinitis and hay fever etc. Extremely high pollen concentration in the spring and summer seasons in month of March, April, August and relatively less concentration in winter and autumn season in the month of October, December, January are recorded. These high concentrations are mainly due to Broussonetia papyrifera tree. Meteorological parameters affect pollen concentration in the atmosphere by two ways its production and dispe...
SYED SHAHID IMRAN BUKHARI*, ZULFIQAR ALI & RIDA AHMAD
...ironments
of asthmatic residential houses (n=50) in Lahore, Pakistan.
PM10 and PM (Total) was monitored in the living rooms and immediate
outdoor of residential household of each selected site using DustTrak
aerosol monitor (model 8533, TSI Inc.). Results of this study indicated
poor air quality in the residential indoor environments of asthmatics. The
2...
Faiza Naeem1, Muhammad Farooq Sabar1, Muhammad Usman Ghani2,*, Qurat Ul Ain1 and Qurat-ul-Ain Zafar1
... a list of significantly asthma-associated genes was created to identify asthma-associated pathways and ranking of genes based on protein interactions and centrality-lethality hypothesis representing that knockdown of influential node and edge leads toward the development of the disease. This ranking allows identification of the influential protein for the targeted drug discovery and therapies. An extensive study of publishe...
Shehar Bano Bhatti1, Muhammad Irfan Malik2, Rabia Faryad Khan1, Mahmood Ul Hassan2, Muhammad Shahbaz Aslam3 and Zaigham Abbas1*
...ious causative agents of asthma, allergens and genetic susceptibility play a key role. HLA is a complex region, and most of the GWAS studies on asthma are limited to simple gene markers. This study aimed to determine the association of HLA DRB1 alleles with atopic asthma in the Pakistani population. Blood samples of 568 subjects were collected from Punjab, Pakistan. HLA typing was performe...
Abo-Elmagdl , Enas K;El-Mougy2, Hala M. T. and Abd El-Salam 3, Manal
... infection and childhood asthma has been suggested. Rapid and accurate diagnosis of RSV infection is crucial for appropriate patient management and infection control. The aim of our study was to compare the diagnostic performance of Binax NOW RSV (BN) as a rapid test for detection of RSV antigen in nasal wash specimens collected from Egyptian infants and young children with the detection of RSV-RNA by reverse transcription polymerase chain reaction (RT-PCR). F...
SYED SHAHID IMRAN BUKHARI1&2* & ZULFIQAR ALI 2
...actitioners dealing with asthma in Lahore. Among 200 practitioners, 166 (83%) responded. One hundred and sixty six asthmatic subjects were selected and given to the practitioners at Gulab Devi hospital, Lahore. Practitioners were asked for a prescription for each subject and also to write views on dietary restrictions in asthmatics. The practitioners prescribed totally thirty patterns of s...
Wasan Ali Hasan1*, Manal Abdulkhaliq Ibrahim2
...ory disorders, including asthma and chronic obstructive pulmonary disease, are prevalent conditions affecting the airways. Current study aimed to investigate the impact of famotidine on respiratory inflammation in rats. Thirty adult male albino rats were segmented into five distinct groups, each group comprising six rats (n=6). A_group (Negative Control) rats received distilled water only, without any drug; B_group (Positive Control) rats underwent ovalbumin s...
Iqra Munir*, Farrah Iftikhar, Hira Fatima, Sunbal Khalil Chaudhari and Roha Ramash
...ants used to cure cough, asthma, fever, influenza, diabetes and liver diseases. 60% plants used to cure digestive diseases, diarrhea, cancer, inflammation, stomachache and dysentery. About 30% plants used to cure cardiovascular diseases and ulcers. The purpose of this study is to recognize wild plants gathered for medicinal purposes by the local residents of Mandi Bahauddin and to document the common names and therapeutic uses associated with these plants....
Bushra AL-Khaqani, Amira Mohammed*
...er of affected people by asthma is rising to reach up to 339 million worldwide. Asthma defined as chronic airway inflammation. A natural substance called resveratrol, which is present in several plants, red wine, and grapes, has been researched for its potential anti-inflammatory, and antioxidant qualities, and to induce relaxation of airway smooth muscle. The current study investigated whether Resveratrol (RES) could lessen...
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